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Cosmetic composition for improving health of scalp and method of preparing the same

A manufacturing method and composition technology, applied in the field of cosmetic composition and its manufacturing, can solve problems such as difficult to prevent hair loss or improve scalp health, difficult skin penetration, etc., to achieve improved scalp health, high safety and stability, The effect of preventing hair loss

Inactive Publication Date: 2017-12-08
OLIPASS COSMECEUTICALS CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] However, in the case of the prior art, the skin penetration is very difficult for the peptide and / or growth factor contained in the cosmetic composition as a protein component, and it is difficult to obtain substantial prevention of hair loss or Satisfactory results for improved scalp health

Method used

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  • Cosmetic composition for improving health of scalp and method of preparing the same
  • Cosmetic composition for improving health of scalp and method of preparing the same
  • Cosmetic composition for improving health of scalp and method of preparing the same

Examples

Experimental program
Comparison scheme
Effect test

manufacture example

[0102] manufacture oligopeptides

[0103] 2-chlorotrityl chlorideresin purchased from Novabiochem (loaded with 0.6 mmol of resin per gram (g)) was put into an automatic peptide synthesizer. Use 15ml of DMF to dissolve the resin and fully react (sweeling) for 5 minutes, add 1ml of 20% (w / v) piperidine DMF solution and shake (shaking), after removing the piperidine DMF solution, use 1ml of DMF solvent and 15ml of MC solvent for cleaning, and then again for cleaning with 15ml of MC solvent.

[0104] Make Fmoc-glycine (Fmoc-gly-OH) 0.5mmol, 1-O-benzotriazole-tetramethyluronium hexafluorophosphate (1-O-Benzotriazole-N,N,N',N'-tetramethyluronium , HBTU) 0.5mmol, N,N-diisopropylethylamine (N,N-diisopropylethylamine, DIEA) 0.5mmol were dissolved in anhydrous DMF 20ml, and activated for 4 minutes. Afterwards, the activated solution was mixed with the resin, and a binding reaction was performed for 30 minutes. After washing the resin with 20 ml MC and 20 ml DMF for 40 seconds, the F...

experiment example 1

[0110] Oligopeptide Stability

[0111] In order to confirm the human body stability of the oligopeptides produced in the above production examples, the presence or absence of skin and scalp irritation due to cytotoxicity was confirmed using the HaCaT cell line which is a human keratinocyte.

[0112] The HaCaT cell strain used in the experiment was cultured at 37° C. in 95% carbon dioxide (CO 2 ) medium, and if it showed a culture degree of 85 to 90% of the area of ​​the culture container, it was treated with trypsin to make After the cells were desorbed and counted, they were subcultured at 5×10 3 cells (cells) / cm 2 . During cell culture, use supplemented with 10% fetal bovine serum (Fetal Bovine Serum) (FBS, GIBCO, Cat.No., 26140-079, the United States (USA)) and 100U / ml penicillin (penicillin), 100μg / ml chain Streptomycin-containing DMEM medium (Dulbecco's Modified Eagle Medium (DMEM, GIBCO, Cat. No. 11995-065, United States (USA))). For subculture, a 75T-flask (NUNC, Ca...

manufacture example 2

[0119] manufacture cosmetic compositions

[0120] In the ratio shown in the following table 2, the complex buffer solution including the oligopeptide, insulin-like growth factor and thymosin-β4, hexose (hexose), polyhydric alcohol (polyhydric alcohol) and electrolyte compound produced by the manufacturing example, and other The ingredients are mixed to make a cosmetic composition.

[0121] In more detail, the following other components are mixed, heated to 80°C to produce a single-phase form, after mixing the oligopeptide, insulin-like growth factor, thymosin-β4 and complex buffer at 55°C, three times at 1000bar After passing through a high-pressure emulsification device, cooling was performed to manufacture Examples 1-3 and Comparative Examples 1-4 which are cosmetic compositions.

[0122] 【Table 2】

[0123]

[0124]

[0125] (unit: based on the total weight of 100g)

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Abstract

This invention relates to a cosmetic composition, which controls sebum secretion of the scalp to thus create an optimal environment for hair growth and activates growth factors for promoting hair strengthening and growth, thereby improving the health of the scalp. A method of preparing the same is also provided. In the cosmetic composition, an oligopeptide functions to create an environment suitable for hair growth by controlling the sebum secretion of the scalp, and also to activate growth factors that are effective at preventing hair loss by promoting hair growth through improvement of blood circulation in the scalp and by strengthening hair through hair follicle activity, thereby improving the health of the scalp and preventing hair loss. The oligopeptide of the invention can exhibit high safety and stability of use and high absorbability into the skin and is thus excellent in improving the health of the scalp, compared to the use of existing peptide compositions.

Description

technical field [0001] The present invention relates to a cosmetic composition that not only creates an optimal environment for controlling the sebum secretion of the scalp to enable hair growth, but also contains growth factors that promote hair strengthening and growth, and a method for producing the same. Revitalizes, thereby improving the health of the scalp. Background technique [0002] The scalp is the place where hair grows using the skin tissue covering the surface of the skull, as a buffer against external physical stimuli or chemical changes to protect the internal tissue. Hair follicles and blood vessels are more abundant than other skin tissues and the distribution of nerves is also very dense. Blood vessels and lymphatic vessels in the subcutaneous tissue supply nutrients and oxygen to the scalp, thereby providing an environment in which hair can grow. [0003] The scalp also excretes harmful substances and wastes in the body, but if cutin and wastes are mixed...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61Q7/00A61P17/14
CPCA61K8/64A61Q7/00A61K8/60A61P17/14A61K8/0291A61K8/14A61K2800/413A61Q5/00A61Q19/00A61K8/345
Inventor 郑信朴钟皓金水晶
Owner OLIPASS COSMECEUTICALS CO
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