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High-permeability plant type skin disinfectant and preparation method thereof

A high-permeability, plant-based technology, applied in the field of high-permeability plant-based skin disinfectant and its preparation, can solve the problems of inconvenience, time-consuming treatment, and easy recurrence, and achieve the effect of preventing recurrence

Inactive Publication Date: 2017-12-08
渭南新秦药物研究有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] In order to solve the problem of easy recurrence, time-consuming and inconvenient treatment in the traditional treatment of warts and herpes, which is not conducive to the promotion of patients, the defects in the existing dosage forms of triterpene saponins for the treatment of genital warts, and The suspension of production of macrocyclic triterpene saponin Xiaoyouling Injection brought troubles to patients. The present invention provides a high-permeability plant-based skin disinfectant and its preparation method

Method used

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  • High-permeability plant type skin disinfectant and preparation method thereof
  • High-permeability plant type skin disinfectant and preparation method thereof

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Effect test

Embodiment 1

[0045] The high-permeability plant type skin disinfectant of the present embodiment is prepared from the following components by weight percentage:

[0046] Macrocyclic triterpene saponins: 0.3%; Dexamethasone: 0.2%; Cosolvent: 40%; Penetrant: 10%; Purified water: 49.5%.

[0047] The co-solvent is soluble in water, and most of them are low-molecular compounds. After forming a complex with the drug, the solubility of the drug can be increased several times or even dozens of times. Its mechanism is four types: soluble complexation of poorly soluble drugs and co-solvents, organic molecular complexes, associations, and formation of soluble salts through metathesis reactions. Co-solvents increase the solubility of insoluble drugs, which is beneficial to the preparation and application of preparations; co-solvents can also reduce some shortcomings of original drugs, improve the quality of preparations and develop new preparations; co-solvents can increase the stability of preparatio...

Embodiment 2

[0059] The high-permeability plant type skin disinfectant of the present embodiment is prepared from the following components by weight percentage:

[0060] Macrocyclic triterpene saponins: 0.1%; Dexamethasone: 0.1%; Cosolvent: 45%; Penetrant: 6%; Purified water: 48.8%.

[0061] Its preparation method comprises the following steps:

[0062] 1) Mixing 1 g of macrocyclic triterpene saponins extracted from the traditional Chinese medicine Fritillaria japonicus with 45 g of medicinal ethanol solution to completely dissolve the macrocyclic triterpene saponins to obtain mixed liquid A;

[0063] 2) Add 1 g of dexamethasone to mixed medicinal solution A, and mix evenly to obtain mixed medicinal solution B;

[0064] 3) Add 488g of purified water to the mixed drug solution B to adjust the pH value of the solution to 4.5-7.5, mix well to obtain the mixed drug solution C;

[0065] 4) Mix the mixed medicinal solution C and 6 g of azone solution evenly to obtain a high-permeability plant-...

Embodiment 3

[0067] The high-permeability plant type skin disinfectant of the present embodiment is prepared from the following components by weight percentage:

[0068] Macrocyclic triterpene saponin: 1%; Dexamethasone: 0.3%; Cosolvent: 55%; Penetrant: 3%; Purified water: 40.7%.

[0069] Its preparation method comprises the following steps:

[0070] 1) Mixing 1 g of macrocyclic triterpene saponins extracted from the traditional Chinese medicine Fritillaria japonicus with 55 g of medicinal ethanol solution to completely dissolve the macrocyclic triterpene saponins to obtain mixed liquid A;

[0071] 2) Add 3 g of dexamethasone to mixed medicinal solution A, and mix evenly to obtain mixed medicinal solution B;

[0072] 3) Add 407g of purified water to the mixed medicinal solution B to adjust the pH value of the solution to 4.5-7.5, and mix evenly to obtain the mixed medicinal solution C;

[0073] 4) Mix the mixed medicinal solution C and 3 g of azone solution evenly to obtain a high-permea...

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Abstract

The invention relates to a high-permeability plant type skin disinfectant. The high-permeability plant type skin disinfectant is prepared from the following components in percentage by weight: 0.1-1 % of macrocyclic triterpenoid saponin, 0.1-0.5 % of dexamethasone, 35-55 % of a cosolvent, 3-15 % of a permeating agent, the balance of purified water. The preparation method comprises the following steps: mixing macrocyclic triterpenoid saponin extracted from the traditional Chinese medicinal material, namely, rhizoma bolbostemmae with medicinal alcohol solution, so that macrocyclic triterpenoid saponin is completely dissolved, and thus a mixed liquid medicine A is obtained; adding dexamethasone into the mixed liquid medicine A, and carrying out uniform mixing, thus obtaining a mixed liquid medicine B; adding purified water into the mixed liquid medicine B for adjusting the pH value of the solution, and carrying out uniform mixing to obtain a mixed liquid medicine C; and uniformly mixing the mixed liquid medicine C and azone solution, so that the high-permeability plant type skin disinfectant is obtained. The high-permeability plant type skin disinfectant disclosed by the invention is free of corrosion, irritation, sensitization, toxicity and contraindication to the skin, no scars are left after diseases are treated, and no relapse occurs.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine disinfectants, and in particular relates to a high-permeability plant-type skin disinfectant and a preparation method thereof. Background technique [0002] The pathogen of warts is human papillomavirus (HPV), which is a DNA virus; the diameter of virus particles is 50-55nm, which cannot be seen by ordinary optical microscopes, and can only be seen with the help of electron microscopes. In recent years, molecular biology research has developed rapidly, and it has been confirmed that there are more than 40 antigenic types of human papillomavirus, that is, there are more than 40 similar but different viruses in this family; Types of human papillomavirus, of which 15 types (6, 11, 16, 18, 30, 31, 32, 42, 43, 44, 51, 52, 53, 54, 55) are related to genital warts, common HPV6, Types 11, 16, and 18, when the immune function is weakened or the body is weak, the risk of condyloma acum...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K31/573A61K9/00A61K47/10A61K47/22A61P31/02A61P31/20A61P17/12
CPCA61K9/0014A61K31/573A61K31/704A61K36/42A61K47/10A61K47/22A61K2300/00
Inventor 王勇王峰王飞
Owner 渭南新秦药物研究有限责任公司
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