Environmental friendly production method of MICA active ester

Abstract

The invention discloses an environmental friendly production method of a MICA active ester. The environmental friendly production method comprises the following steps: oximating, alkylating, chloridizing, cyclizing, and preparing an intermediate. The production method realizes the recycling of the materials, so that the cost is lowered, and the amount of produced wastes and wastewater is reduced; sodium acetate, a byproduct, is recrystallized in the S1 and used for cyclization in the S4, so that the amount of wastewater and the salt content of the waste water are reduced; the conventional process generally uses potassium carbonate to provide an alkaline environment in the S2, the use amount of the potassium carbonate is generally more than 2 equivalent weights, the defects are as follows: 1, the stirring is strenuous if the slat content is too high in the reaction process; 2, a large quantity of water is needed in the later processing to dissolve an inorganic salt, then a large quantity of high salt content wastewater is produced, but the amount of solid salt is greatly reduced in the reaction process after an organic alkali is used, the organic alkali is recycled in the later processing, and the cost and the amount of wastewater are reduced; a batch feeding mode is used in the S3, so that the use amount of sulfonyl chloride is reduced at the same conversion rate; 2-mercaptobenzothiazole, a byproduct produced in the reaction, is recycled in the S5, and is recycled again so as to be used in the synthesis of diphenyl thiazole disulfide.

Description

Technical field: [0001] The invention relates to an environment-friendly production method of MICA active ester. Background technique: [0002] Cefixime is the third-generation oral cephalosporin, which was first developed and marketed by Fujisawa Pharmaceutical Co., Ltd. in Japan. It was approved by the US FDA in 1987 and developed rapidly in Europe and the United States. In 1998, cefixime had surpassed Cefuroxime axetil has become the oral cephalosporin with the highest market share. my country has also invested heavily in the production process of cefixime, and once included cefixime in the "Ninth Five-Year Plan" and the 2010 medical science and technology development plan. MICA active ester is a key intermediate in the synthesis of cefixime, and has huge market demand and commercial value. Although there is a relatively mature process for the production of MICA active ester, the production cost of the existing process is high and the amount of waste water is large. Th...

AI Technical Summary

Problems solved by technology

Although there is a relatively mature process for the production of MICA active ester, the production cost of the existing process is high and the amount of waste water is large.

Existing technology does not have the solution to this

Images