Heart-sealing gel and preparation method thereof

A gel and hydrogel technology, applied in the field of medical devices, can solve the problem of no heart tissue sealing, and achieve the effect of extensive adhesion and extensive cell affinity

Active Publication Date: 2017-12-15
HANGZHOU YAHUI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no medical product for heart tissue sealing in China

Method used

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  • Heart-sealing gel and preparation method thereof
  • Heart-sealing gel and preparation method thereof
  • Heart-sealing gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Dissolve 50mg of gelatin in 1mL of PBS (pH value 7.4), the temperature of the dissolving water bath is 40°C, and the final concentration of gelatin aqueous solution is 5% (w / v); add HPAE-Py polymer monomer to the above gelatin aqueous solution , mix well at room temperature to obtain an aqueous solution of the HPAE-Py / Geln mixture, the final concentration of the HPAE-Py polymer monomer in the aqueous solution of the mixture is 10% (w / v); add chlorine to the aqueous solution of the HPAE-Py / Geln mixture Ferric chloride solution, vortex rapidly, obtain gel precursor solution, the ferric chloride solution concentration that adds is 150mM, the volume of the ferric chloride solution that adds is 20% of the aqueous solution volume of HPAE-Py / Geln mixture; Gel The precursor solution was drawn into the syringe with the needle removed. The 3D-printed brush head is quickly installed on the syringe head, and after the gel precursor solution in the syringe brush is gelled, it is qui...

Embodiment 2

[0036] Dissolve 100mg of gelatin in 1mL of PBS (pH 7.4), the temperature of the dissolving water bath is 40°C, and the final concentration of gelatin aqueous solution is 10% (w / v); add HPAE-Py polymer monomer to the above gelatin aqueous solution , mix well at room temperature to obtain an aqueous solution of HPAE-Py(30%) / Geln mixture, the final concentration of HPAE-Py polymer monomer in the aqueous solution of the mixture is 30% (w / v); to HPAE-Py(30%) Add ferric chloride solution in the aqueous solution of Geln mixture, vortex rapidly, obtain gel precursor solution, the concentration of the ferric chloride solution that adds is 200mM, the volume of the ferric chloride solution that adds is HPAE-Py (30%) / 25% by volume of an aqueous solution of Geln mixture; draw the gel precursor solution into a syringe from which the needle has been removed. The 3D-printed brush head is quickly installed on the syringe head, and after the gel precursor solution in the syringe brush is gelle...

Embodiment 3

[0038] Dissolve 100 mg of gelatin in 1 mL of PBS (pH 7.4), the temperature of the dissolving water bath is 40°C, and the final concentration of gelatin aqueous solution is 10% (w / v); add HPAE-Py polymer monomer to the above gelatin aqueous solution , mix well at room temperature to obtain an aqueous solution of the HPAE-Py / Geln mixture, and the final concentration of the HPAE-Py polymer monomer in the aqueous solution of the mixture is 50% (w / v); add to the aqueous solution of the HPAE-Py / Geln mixture Ferric chloride solution, vortex rapidly, obtains gel precursor solution, the ferric chloride solution concentration that adds is 200mM, and the volume of the ferric chloride solution that adds is the 30% of the aqueous solution volume of HPAE-Py / Geln mixture; The gel precursor solution is drawn into the syringe with the needle removed. Quickly install the 3D printed brush head on the syringe head, and after the gel precursor solution in the syringe brush is gelled (the gelation ...

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Abstract

The invention relates to a heart-sealing gel and a preparation method thereof. Specifically speaking, a pyrrole-capped hyperbranched polyaminoester monomer (HPAE-Py) containing dopamine groups and gelatin (Geln) are dissolved into PBS (phosphate buffer solution), the pH value of which is 7.4, so that HPAE-Py / Geln mixed solution is prepared; and aqueous ferric chloride solution is added into the HPAE-Py / Geln mixed solution, so that gel precursor solution is prepared. Ferric chloride can ensue the complexing and self-polymerization of dopamine in the HPAE-Py polymer monomer, so that pyrrole in HPAE-Py is polymerized and complexed with the gelatin, and ultimately, the conductive sticky hydrogel is constructed. At the initial stage of formation, the hydrogel disclosed by the invention has the characteristics of softness and stickiness, and can be applied on a tissue wound, preventing adverse fluid leakage; pyrrole groups are polymerized into polypyrrole, which serves as crosslinking sites to consolidate a gel network structure; the gel has high strength and electrical conductivity; the gel has good biocompatibility, can be degraded, and can be used as a surgical sealant for, for example, wound sealing after cardiac surgery.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a preparation method and application of a conductive viscous hydrogel. Background technique [0002] Hydrogel is a kind of three-dimensional network structure polymer with hydrophilic groups. Due to the physical crosslinking and chemical crosslinking between polymer chains, hydrogel can be swollen by water but insoluble in water and maintain a certain shape. In medicine, hydrogels can be used for wound dressing, anti-adhesion after surgery, hemostasis during surgery, tissue filling, and prevention of interstitial fluid leakage or gas leakage, etc. [0003] Hyperbranched polymer monomers have attracted more and more attention from researchers in the field of hydrogels, because hyperbranched structures can introduce many characteristic functional groups, thus bringing more abundant properties to hydrogels. [0004] Ferric chloride is a commonly used oxidant for the polymerization of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61L24/10A61L24/04C08J3/075C08L79/02C08L89/00
CPCA61L24/001A61L24/0031A61L24/0042A61L24/046A61L24/104A61L2400/04C08J3/075C08J2379/02C08J2489/00C08L79/02C08L89/00
Inventor 王玮梁爽李丹汪伟
Owner HANGZHOU YAHUI BIOTECH CO LTD
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