Heart-sealing gel and preparation method thereof
A gel and hydrogel technology, applied in the field of medical devices, can solve the problem of no heart tissue sealing, and achieve the effect of extensive adhesion and extensive cell affinity
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Embodiment 1
[0034] Dissolve 50mg of gelatin in 1mL of PBS (pH value 7.4), the temperature of the dissolving water bath is 40°C, and the final concentration of gelatin aqueous solution is 5% (w / v); add HPAE-Py polymer monomer to the above gelatin aqueous solution , mix well at room temperature to obtain an aqueous solution of the HPAE-Py / Geln mixture, the final concentration of the HPAE-Py polymer monomer in the aqueous solution of the mixture is 10% (w / v); add chlorine to the aqueous solution of the HPAE-Py / Geln mixture Ferric chloride solution, vortex rapidly, obtain gel precursor solution, the ferric chloride solution concentration that adds is 150mM, the volume of the ferric chloride solution that adds is 20% of the aqueous solution volume of HPAE-Py / Geln mixture; Gel The precursor solution was drawn into the syringe with the needle removed. The 3D-printed brush head is quickly installed on the syringe head, and after the gel precursor solution in the syringe brush is gelled, it is qui...
Embodiment 2
[0036] Dissolve 100mg of gelatin in 1mL of PBS (pH 7.4), the temperature of the dissolving water bath is 40°C, and the final concentration of gelatin aqueous solution is 10% (w / v); add HPAE-Py polymer monomer to the above gelatin aqueous solution , mix well at room temperature to obtain an aqueous solution of HPAE-Py(30%) / Geln mixture, the final concentration of HPAE-Py polymer monomer in the aqueous solution of the mixture is 30% (w / v); to HPAE-Py(30%) Add ferric chloride solution in the aqueous solution of Geln mixture, vortex rapidly, obtain gel precursor solution, the concentration of the ferric chloride solution that adds is 200mM, the volume of the ferric chloride solution that adds is HPAE-Py (30%) / 25% by volume of an aqueous solution of Geln mixture; draw the gel precursor solution into a syringe from which the needle has been removed. The 3D-printed brush head is quickly installed on the syringe head, and after the gel precursor solution in the syringe brush is gelle...
Embodiment 3
[0038] Dissolve 100 mg of gelatin in 1 mL of PBS (pH 7.4), the temperature of the dissolving water bath is 40°C, and the final concentration of gelatin aqueous solution is 10% (w / v); add HPAE-Py polymer monomer to the above gelatin aqueous solution , mix well at room temperature to obtain an aqueous solution of the HPAE-Py / Geln mixture, and the final concentration of the HPAE-Py polymer monomer in the aqueous solution of the mixture is 50% (w / v); add to the aqueous solution of the HPAE-Py / Geln mixture Ferric chloride solution, vortex rapidly, obtains gel precursor solution, the ferric chloride solution concentration that adds is 200mM, and the volume of the ferric chloride solution that adds is the 30% of the aqueous solution volume of HPAE-Py / Geln mixture; The gel precursor solution is drawn into the syringe with the needle removed. Quickly install the 3D printed brush head on the syringe head, and after the gel precursor solution in the syringe brush is gelled (the gelation ...
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