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Improved tylvalosin tartrate soluble powder and a preparing method thereof

A technology of tylvalosin and tartaric acid, which is applied in the field of improved tylvalosin tartrate soluble powder and its preparation, can solve the problems of animal refusal to feed, no effect of solubilization, failure to achieve preventive or therapeutic effect, etc., and achieve increased stability Sexuality, ensuring drug intake, and improving bioavailability

Inactive Publication Date: 2017-12-19
CHINA ANIMAL HUSBANDRY IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The soluble excipients used in the preparation of tyvalomectin tartrate soluble powder in the prior art are anhydrous glucose or lactose, etc., which basically have no solubility aiding effect.
In addition, due to the strong bitter taste of tyvalin tartrate, animal refusal to eat often occurs in clinical use, and the expected preventive or therapeutic effect cannot be achieved.

Method used

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Examples

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Effect test

preparation example Construction

[0049] The present invention also provides a preparation method for the above-mentioned tylvalosin tartrate soluble powder, comprising the following steps: mixing the sour taste regulator, the corrective agent, the food-inducing agent, the water-soluble carrier, the tylvalosin tartrate Vanmectin and the cyclodextrin are mixed to obtain tylvanectin tartrate soluble powder.

[0050] The present invention has no special limitation on the mixing method, and the mixing method known to those skilled in the art can be used.

[0051] As a preferred embodiment, in the present invention, the sour taste regulator, the flavoring agent and the food-attractant are mixed with part of the water-soluble carrier in proportion; then the obtained mixture is mixed with the The tylvalosin tartrate, the remaining water-soluble carrier and the cyclodextrin are uniformly mixed in proportion to obtain the tylvalosin tartrate soluble powder.

[0052] In the present invention, the mass of the water-solu...

Embodiment 1

[0059] According to the mass ratio of tivalamectin tartrate: β-cyclodextrin: lactose: anhydrous glucose: tartaric acid: stevioside: attractant peptide = 16:6:30:27:0.5:0.4:0.1, the specific preparation The steps are:

[0060] (1) Proportionally take tartaric acid, stevioside, attractant peptide, and 1 / 4 of the total mass of lactose and anhydrous glucose, pass through a 60-mesh sieve together, add to the mixer, and perform pre-mixing;

[0061] (2) Take the remaining materials in proportion and add them to the mixture in step (1), and start to mix until they are evenly mixed;

[0062] (3) After the mixing is completed, the obtained material is packed to obtain a finished product.

[0063] Determination of tyvalactin tartrate content: refer to the determination method under the item [Content Determination] of the first volume of "National Standards for Veterinary Drugs" (Chemical Drugs, Chinese Medicine Volume); [solubility] refer to "Chinese Veterinary Pharmacopoeia" (2015 Edit...

Embodiment 2

[0067] Tylvalosin tartrate: hydroxypropyl-β-cyclodextrin: maltodextrin: anhydrous glucose: L+ tartaric acid: cyclamate: ethyl maltol = 25:25:23.7:25:0.8:0.16:0.34 The mass ratio is to prepare the material, and its specific preparation steps are:

[0068] (1) Take maleic acid, cyclamate, ethyl maltol, and 1 / 4 of the total mass of maltodextrin and anhydrous glucose in proportion, and pass through an 80-mesh sieve together, and sieve three times for pre-mixing;

[0069] (2) Take the rest of the materials and the mixed materials in step (1) in proportion and add them to the dry and clean empty hopper of the mixer, and start to mix until they are evenly mixed;

[0070] (3) After the mixing is completed, the obtained material is packed to obtain a finished product.

[0071] After testing, the prepared tylvalosin tartrate soluble powder has a content of 25% of tylvalosin tartrate and a solubility of 20000ppm is qualified.

[0072] When the tylvalosin tartrate soluble powder prepare...

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Abstract

The invention relates to improved tylvalosin tartrate soluble powder, and relates to the technical field of veterinary drug preparations. The soluble powder includes, by mass, 5-25 parts of tylvalosin tartrate, 5-40 parts of cyclodextrin, 45-85 parts of a water-soluble carrier, 0.1-1 part of a sour taste conditioner, 0.1-1 part of a corrective and 0.05-0.5 part of an attractant. The soluble powder is prepared by sieving the components and mixing the components. The solubility (calculated based on the tylvalosin tartrate that is an effective component) of the soluble powder at room temperature can be 20000 ppm or above, while the solubility of common tylvalosin tartrate soluble powder is about 10000 ppm. The solubility of the tylvalosin tartrate is obviously increased, and the improved tylvalosin tartrate soluble powder is good in stability, good in palatability and high in medicine bioavailability.

Description

technical field [0001] The invention relates to the technical field of veterinary drug preparations, in particular to an improved tylvanectin tartrate soluble powder and a preparation method thereof. Background technique [0002] Tyvalin tartrate (abbreviated as AIV) is a kind of macrolide antibiotics specially used for livestock and poultry which is semi-synthesized by biological fermentation on the basis of tylosin. AIV is a high-efficiency macrolide antibiotic, which is obtained by acetylation of 3-OH and isovalerylation of 4"-OH of tylosin. Studies have shown that AIV has a strong affinity for 70S ribosomes and has good cell membrane permeability , so the antibacterial and anti-mycoplasma activities are higher than tylosin, and it is effective for mycoplasma resistant to other antibiotics (including tylosin), and has high application value. AIV is effective against many gram-positive bacteria And certain negative bacteria have resistance activity, including mycoplasma, ...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/7048A61K47/69A61K47/26A61K47/12A61K47/18A61K47/36A61K47/20A61K47/22A61P31/04
CPCA61K9/145A61K9/146A61K31/7048
Inventor 庞谦桂亮刘姣马宏星程成张誉赢
Owner CHINA ANIMAL HUSBANDRY IND
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