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Externally applied skin tissue protection and repair preparation

A technology of skin protection and compound preparations, which is applied in the field of medicine and can solve problems such as the huge demand for skin damage

Active Publication Date: 2017-12-26
NANJING JIANZHUANG BIOTECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 1) It must show significant radiotherapy protection;
[0006] 2) It must show a certain radiotherapy protective effect on most organs;
[0007] 3) It must be able to be administered through a route with good patient compliance;
[0008] 4) Must have acceptable toxicity and protective time window effect;
[0012] Although there is a huge clinical demand for skin tissue protection and repair preparations and corresponding radiation inflammation or skin damage caused by radiation therapy, at present, there are no corresponding mature and reliable products available for selection

Method used

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  • Externally applied skin tissue protection and repair preparation
  • Externally applied skin tissue protection and repair preparation
  • Externally applied skin tissue protection and repair preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Embodiment 1, is used for the preparation of the composite preparation of skin protection and repair

[0066] The preparation of formula 1 (compound preparation a):

[0067] (1) Weigh 150g PEG200 and 150g PEG6000 respectively, mix well, and heat to 55°C to obtain solution 1;

[0068] (2) Weigh 25g of naringenin, 1g of quercetin, and 1g of luteolin respectively, add them into solution 1, and stir until they are completely dissolved to obtain solution 2;

[0069] (3) Add 100ml of water to solution 2, stir well until it is completely miscible, and cool to room temperature to obtain compound preparation a.

[0070] The preparation of formula 2 (compound preparation b):

[0071] (1) Weigh 120g PEG200, 100g PEG2000 and 150g PEG5000 respectively, mix well, and heat to 75°C to obtain solution 1;

[0072] (2) Weigh 25g of naringenin respectively, add it into solution 1, and fully stir until completely dissolved to obtain solution 2;

[0073] (3) Weigh 1g of zinc chloride, 0....

Embodiment 2

[0088] Embodiment 2. Composite preparation skin repair experiment

[0089] Experimental animals and experimental methods:

[0090] (1) 15 SPF-grade Balb / c mice (purchased from Beijing Weitong Lihua Experimental Animal Company), were divided into 5 groups (3 mice in each group), and raised in an isolated, ventilated, constant temperature and humidity environment;

[0091] (2) Shave the back hair of all mice to expose the back skin, and cut off a piece of epidermal tissue with an area of ​​about 4mm×4mm in the middle of the back with sterilized ophthalmic scissors and ophthalmic forceps, and apply iodine for disinfection , set this day as the 0th day after the wound is caused;

[0092] (3) On the first day after the wound is caused, no treatment is performed to allow the wound to heal;

[0093] (4) From the second day after the wound was caused, the wound on the back of the mouse was smeared with medicine every day, and the repair situation of the wound was recorded;

[0094]...

Embodiment 3

[0101] Example 3. Compound preparation prevention / treatment experiment of radiation dermatitis

[0102] Patient enrollment conditions:

[0103] (1) Patients with bilateral neck radiotherapy; the patients enrolled in the group received the same dose of radiation on both sides of the neck every day;

[0104] (2) The starting point of the test investigation starts from the appearance of grade I skin lesions;

[0105] (3) Test and investigation indicators:

[0106] a. Time to appearance of skin damage at all levels (RTOG grading standard)

[0107] b. Compared with the control side without the test protective agent, whether the test protective agent reduces the radiation damage of the unilateral neck skin

[0108] c. The final results will be unified and summarized after all the cases in the group have been tested

[0109] (4) Test termination indicators:

[0110] a. Regardless of any skin damage or side effects greater than / equal to grade III on both sides, the test will be t...

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Abstract

The invention relates to an externally applied skin tissue protection and repair preparation. The compound preparation includes the following components: (1) polyethylene glycol; (2) water; and (3) a flavonoid compound. The compound preparation can: (1) repair skin injury or promote wound healing; (2) eliminate scars; (3) prevent or treat radiotherapy caused skin damage; and (4) prevent or treat radiodermatitis.

Description

technical field [0001] The invention belongs to the field of medicine, in particular, the invention relates to an external skin tissue protection and repair preparation. Background technique [0002] Skin tissue, as the outermost natural protective layer of the human body, often faces severe damage due to various internal and external factors. Common events that cause skin damage include exogenous wounds, endogenous or exogenous inflammation and immune reaction and many other factors. In addition to accidents that lead to skin damage, the treatment process of many diseases often leads to different skin damage or scar accumulation after damage due to the treatment process. [0003] The goal of radiation therapy is to destroy tumor cells while causing minimal damage to normal cells. Due to the natural nature of radiation, it will inevitably cause side effects of varying degrees, and the intensity of side effects depends on the dose of radiation and the sensitivity of the irr...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K31/4166A61K33/30A61K31/727A61K47/10A61P17/02A61P17/00A61K8/49A61K8/73A61K8/86A61Q19/00
CPCA61K8/4946A61K8/498A61K31/352A61K31/4166A61K31/727A61K47/10A61Q19/00A61K33/14A61K47/22A61K47/02A61K8/735A61K8/20A61P17/16A61P17/00A61Q17/04A61K2300/00A61K8/86A61P17/02A61K9/0014A61K33/30A61Q19/08A61K2800/92A61K8/37A61K8/49A61K8/494
Inventor 曾薇
Owner NANJING JIANZHUANG BIOTECH LTD
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