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Method for screening chemical risk substances such as nitrofuran antibiotics in toiletries

A technology of nitrofuran and cleaning products, which is applied in the field of screening of chemical risk substances of nitrofuran antibiotics, can solve the problems of unreported detection methods, insufficient prevention ability, lagging behind the supervision of chemical risk substances, etc. The effects of sustainable and healthy development, promotion of healthy and standardized development, and standardization of market economic rules and business order

Active Publication Date: 2018-01-05
CHINESE ACAD OF INSPECTION & QUARANTINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 2. The supervision of chemical risk substances in toiletries is relatively lagging behind, and the prevention ability is insufficient
However, there is no report on the detection method of toilet products using high-resolution mass spectrometry.

Method used

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  • Method for screening chemical risk substances such as nitrofuran antibiotics in toiletries
  • Method for screening chemical risk substances such as nitrofuran antibiotics in toiletries
  • Method for screening chemical risk substances such as nitrofuran antibiotics in toiletries

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] A method for detecting chemical risk substances of nitrofuran antibiotics in toiletries, comprising the steps of:

[0051] After the pretreatment steps of extraction, centrifugation, purification, filtration and other pretreatment steps, the sample solution obtained by ultra-high pressure liquid chromatography-quadrupole-electrostatic field orbitrap high-resolution mass spectrometry analysis and detection; ultra-high pressure liquid chromatography-quadrupole In rod-electrostatic field orbitrap high-resolution mass spectrometry analysis and detection, the chromatographic separation conditions are as follows:

[0052] Chromatographic column: Waters ACQUITY UPLC HSS Phenyl, length 100mm, inner diameter 2.1mm, particle size 1.8μm; column temperature: 30°C; flow rate: 0.4mL min -1 ;Injection volume: 5μL, see Table 1 and Table 2 for mobile phase and gradient elution program:

[0053] Table 1 Chromatographic mobile phase and gradient elution program in positive ion mass spect...

Embodiment 2

[0065] 1. Instruments and reagents

[0066] Dionex UltiMate 3000 fast high-performance liquid chromatography system (Thermo Fisher, USA); QExactive Focus quadrupole-electrostatic field orbitrap high-resolution mass spectrometer (Thermo Fisher, USA); Milli-Q ultrapure water instrument (Millipore, USA); Vortex-Genie 2 vortex oscillator (Scientific Industries, USA).

[0067] Methanol, acetonitrile (chromatographically pure, American Thermo Fisher Company); ammonium hydroxide, formic acid (chromatographically pure, American DimaTechnology Company); laboratory water is deionized water. Carbon eighteen, N-propyl ethylenediamine and graphitized carbon black (Germany Macherey-Nagel company); Multi-wall carbon nanotubes (Germany Miltenyi Biotec GmbH company); Anhydrous magnesium sulfate, sodium chloride (Guangzhou Xilong Chemical Industry limited liability company); 0.22 μm microporous membrane (Pall Corporation, USA).

[0068] Prepare 500-1000μg mL respectively -1 The standard stoc...

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Abstract

The invention discloses a method for screening chemical risk substances such as nitrofuran antibiotics in toiletries. The method comprises (1) establishing an accurate mass database and a mass spectral database of compounds to be detected, (2) pre-treating a toiletry sample through extraction, centrifugation, purification and filtration, and carrying out ultrahigh-pressure liquid chromatography-quadrupole-electrostatic field orbitrap high resolution mass spectrometry analysis detection on the sample solution, and (3) comparing and analyzing the test result in the step (2) and the built accurate mass database and mass spectral database in the step (1) and carrying out nitrofuran antibiotic chemical risk substance nitrofuran antibiotic screening. The method has high accuracy, strong specificity and high sensitivity and can be applied to daily detection and quality control of the toiletries.

Description

technical field [0001] The invention relates to a screening method for chemical substances, in particular to a chemical risk of nitrofuran antibiotics in toiletries based on ultra-high pressure liquid chromatography-quadrupole-electrostatic field orbitrap high-resolution mass spectrometry Substance screening methods. Background technique [0002] 1. Chemical risk substances in toiletries have potential harmful effects on consumers' personal health. [0003] From the very beginning of its birth, toiletries have provided protection for people's pursuit of a clean, healthy and fashionable life. With the continuous development and progress of society, people's pursuit of a clean, healthy and fashionable lifestyle has also been continuously upgraded, thus driving the development of toiletries. The industry has stepped into the fast lane of development and upgrading. At present, there are a wide variety of products in the cleaning and care products market, and functional, subdiv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/72
Inventor 马强孟宪双白桦吕悦广胡明珠郭项雨闫萌萌陈萌
Owner CHINESE ACAD OF INSPECTION & QUARANTINE
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