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Seville orange flower calyx alkaloid and preparation method thereof, as well as application of alkaloid to weight-reducing medicine

A technology of alkaloids and total alkaloids, applied in drug combinations, metabolic diseases, pharmaceutical formulas, etc., can solve the problems of lack of research reports on weight loss function, and achieve improved weight loss effect, low drug dosage, and lower fat and triglycerides The effect of content

Inactive Publication Date: 2018-01-09
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research reports on Daidaihua alkaloids and their weight loss function are relatively scarce

Method used

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  • Seville orange flower calyx alkaloid and preparation method thereof, as well as application of alkaloid to weight-reducing medicine
  • Seville orange flower calyx alkaloid and preparation method thereof, as well as application of alkaloid to weight-reducing medicine
  • Seville orange flower calyx alkaloid and preparation method thereof, as well as application of alkaloid to weight-reducing medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1 prepares from generation to generation calyx alkaloids (CAVAAs) from generation to generation calyx

[0042](1) Place Daidai calyx (Citrus aurantium L.var.amara Engl) in an electric blast drying oven at 60°C for 12 hours, pulverize it with a pulverizer, and pass through a 60-mesh sieve to obtain Daidai calyx coarse powder; Fraction 1% hydrochloric acid acidification volume fraction is 60% ethanol aqueous solution, the volume ratio of hydrochloric acid and 60% ethanol aqueous solution is 1:10, obtains acidified ethanol solution; The substituted calyx coarse powder 100g is called, and is extracted by heating and refluxing with acidified ethanol solution, wherein The liquid ratio is 1g:10mL, the reflux extraction temperature is 75°C, the reflux extraction time is 4h, and the reflux extraction times are 4 times; then the extracts are combined, centrifuged at 3000r / min for 12min, the supernatant is taken, and the supernatant is evaporated overnight Concentrate u...

Embodiment 2

[0045] Embodiment 2 prepares from generation to generation calyx alkaloids (CAVAAs) from generation to generation calyx

[0046] (1) Place Daidai calyx (Citrus aurantium L.var.amara Engl) in an electric blast drying oven at 55°C for 18 hours, pulverize it with a pulverizer, and pass through a 50-mesh sieve to obtain Daidai calyx coarse powder; Fraction 1.5% hydrochloric acid acidification volume fraction is 70% ethanol aqueous solution, the volume ratio of hydrochloric acid and 70% ethanol aqueous solution is 1:5, obtains acidified ethanol solution; Said 100g of substituted calyx coarse powder, is extracted by heating reflux with acidified ethanol solution, wherein The liquid ratio is 1g:13mL, the reflux extraction temperature is 85°C, the reflux extraction time is 3h, and the reflux extraction times are 3 times; then the extracts are combined, centrifuged at 4000r / min for 10min, the supernatant is taken, and the supernatant is evaporated overnight Concentrate under reduced pr...

Embodiment 3

[0049] Example 3 Prepared from generation calyx alkaloids (CAVAAs)

[0050] (1) Place Daidai calyx (Citrus aurantium L.var.amara Engl) in an electric blast drying oven at 50°C for 24 hours, pulverize it with a pulverizer, and pass through a 40-mesh sieve to obtain Daidai calyx coarse powder; Fraction 2% hydrochloric acid acidification volume fraction is 80% ethanol aqueous solution, and the volume ratio of hydrochloric acid and 80% ethanol aqueous solution is 2:5, obtains acidified ethanol solution; Substitute calyx coarse powder 100g, heat reflux extraction with acidified ethanol solution, wherein The liquid ratio is 1g:15mL, the reflux extraction temperature is 100°C, the reflux extraction time is 2h, and the number of reflux extraction is 2 times; then the extracts are combined, centrifuged at 5000r / min for 8min, the supernatant is taken, and the supernatant is evaporated overnight Concentrate under reduced pressure at 60°C to the extract form to obtain the total alkaloid e...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and discloses seville orange flower calyx alkaloid and a preparation method thereof, as well as application of the alkaloid to a weight-reducing medicine. The method comprises the following steps: (1) drying, smashing and sieving seville orange flower calyx, thereby obtaining coarse powder, acidifying an ethyl alcohol aqueous solution with hydrochloric acid, thereby obtaining an acidified ethyl alcohol aqueous solution, and performing heating reflux extraction on the coarse powder by adopting the acidified ethyl alcohol aqueous solution, centrifugating an extracting solution, and concentrating supernate, thereby obtaining an extract;(2) dissolving the extract with the hydrochloric acid, extracting filtrate withchloroform, and removing the chloroform layer, thereby obtaining an alkaloid solution, and adjusting the alkaloid solution to 6 to 7, then performing filtration, and continuously adjusting the pH to 10 to 11, thereby obtaining an alkaline solution; (3) extracting the alkaline solution with the chloroform, washing a chloroform extracting solution, dewatering the chloroform extracting solution, andperforming concentration drying, thereby obtaining the seville orange flower calyx alkaloid. The seville orange flower calyx alkaloid disclosed by the invention is outstanding in fat reducing and weight losing activity; the use dosage is small; under the same dosage, the toxic and side effects are relatively low.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a generation-generation calyx alkaloid, a preparation method thereof and an application in weight loss medicine. Background technique [0002] Alkaloids refer to a class of nitrogen-containing organic substances derived from the biological world. Most of them have a relatively complex ring structure, and nitrogen atoms are combined in the ring; most of them are alkaline and can form salts with acids; most of them have significant physiological activity. In traditional Chinese medicine, many medicinal materials contain alkaloid components, which usually have strong pharmacological activity. For example, lotus leaf alkaloids have lipid-lowering and weight-reducing effects, Radix Radix alkaloids have antiviral effects, lycorine-type alkaloids have inhibitory effects on influenza virus, measles virus, polio virus and SARS coronavirus, and matrine has an antivir...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61P3/04A61K133/00
Inventor 姜建国申春燕王天星
Owner SOUTH CHINA UNIV OF TECH
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