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Multifunctional bioactive glass-ceramic nano material as well as preparation method and application thereof

A technology of bioactive glass and glass-ceramics, which is applied in the direction of wave energy or particle radiation treatment materials, nanotechnology, nanotechnology, etc., can solve the problems of easy agglomeration and lack of modification sites, and achieve stable performance and good solubility , Excellent antioxidant effect

Active Publication Date: 2021-11-19
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research and application of BGN are still in their infancy, and there are still difficulties and challenges such as easy aggregation and lack of modification sites.

Method used

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  • Multifunctional bioactive glass-ceramic nano material as well as preparation method and application thereof
  • Multifunctional bioactive glass-ceramic nano material as well as preparation method and application thereof
  • Multifunctional bioactive glass-ceramic nano material as well as preparation method and application thereof

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preparation example Construction

[0040] Therefore the first object of the present invention is to provide a kind of preparation method of multifunctional bioactive glass-ceramic nanomaterial, comprising the following steps:

[0041] 1) Synthesis of BGN by sol-gel template method: add absolute ethanol and deionized water into a 250mL round-bottomed flask at a molar ratio of 3:1 and mix thoroughly, then add 10g of template-catalyst dodecylamine (DDA), Stir at 40°C until the DDA is fully dissolved, then drop 4mL tetraethyl orthosilicate (TEOS) into the above mixed solution under continuous stirring, and add triethyl phosphate (TEP) dropwise into the above reaction system after 30 minutes of reaction , continue to stir for 15 minutes, add 1mL 5mol L -1 The aqueous solution of calcium nitrate tetrahydrate was reacted at 40°C for 3 hours; the reaction product was collected by centrifugation, washed with absolute ethanol and deionized water, and calcined in a muffle furnace at 600-650°C for 3-3 hours after freeze-dr...

Embodiment 1

[0053] 1) Synthesis of BGN by the classic sol-gel template method: add absolute ethanol and deionized water into a 250mL round-bottomed flask at a molar ratio of 3:1 and mix thoroughly, then add 10g of template-catalyst DDA, and place at 40°C Stir in medium until the DDA is fully dissolved, then drop 4mL tetraethyl orthosilicate (TEOS) into the above mixed solution under the condition of continuous stirring, react for 30 minutes, add TEP dropwise into the above reaction system, continue stirring for 15 minutes, add 1mL 5mol L -1 The aqueous solution of calcium nitrate tetrahydrate was reacted at 40°C for 3 hours; the reaction product was collected by centrifugation, washed with absolute ethanol and deionized water, and after being freeze-dried, it was calcined in a muffle furnace at 650°C for 3 hours to obtain BGN product;

[0054] 2) Preparation of Mo-3BGN by hydrothermal method: Molybdenum acetylacetonate and BGN were completely dispersed in 10 mL of 75% ethanol solution at ...

Embodiment 2

[0056] 1) Synthesis of BGN by the classic sol-gel template method: add absolute ethanol and deionized water into a 250mL round-bottomed flask at a molar ratio of 3:1 and mix thoroughly, then add 10g of template-catalyst DDA, and place at 40°C Stir in medium until the DDA is fully dissolved, then drop 4mL tetraethyl orthosilicate (TEOS) into the above mixed solution under the condition of continuous stirring, react for 30 minutes, add TEP dropwise into the above reaction system, continue stirring for 15 minutes, add 1mL 5mol L -1 The aqueous solution of calcium nitrate tetrahydrate was reacted at 40°C for 3 hours; the reaction product was collected by centrifugation, washed with absolute ethanol and deionized water, and after being freeze-dried, it was calcined in a muffle furnace at 630°C for 5 hours to obtain BGN product;

[0057] 2) Preparation of Mo-3BGN by hydrothermal method: Molybdenum acetylacetonate and BGN were completely dispersed in 10 mL of 75% ethanol solution at ...

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Abstract

The invention discloses a multifunctional bioactive glass-ceramic nano material as well as a preparation method and application thereof. The method comprises the steps of synthesizing BGN by taking TEOS, TEP and calcium nitrate tetrahydrate as a silicon source, a phosphorus source and a calcium source respectively based on a sol-gel template method; and mixing BGN and molybdenum acetylacetonate, carrying out a hydrothermal reaction, and obtaining the molybdenum-doped bioactive glass-ceramic nano material. The sol-gel template method and the hydrothermal method used in the invention are environment-friendly, convenient to operate and low in raw material cost; and the prepared Mo-BGN has excellent photo-thermal performance, oxidation resistance, biocompatibility, anti-inflammatory property and blood vessel promotion capability, and meanwhile, the Mo-BGN also shows antibacterial and anti-tumor properties under near-infrared laser irradiation, so that the nano material has a very good application prospect in infection / tumor postoperative tissue regeneration.

Description

technical field [0001] The invention belongs to the technical field of degradable biomedical materials, and in particular relates to a multifunctional bioactive glass-ceramic nanomaterial and its preparation method and application. Background technique [0002] As the first line of defense against virus invasion, the skin inevitably faces the threat of serious canceration and trauma. Although there are mature treatment options for skin tumor treatment and wound repair, the synergistic treatment of tumors and wounds is still a major clinical challenge. Especially for the postoperative treatment of local solid tumors, not only is there a risk of tumor recurrence, but also the chronic inflammatory microenvironment at the tumor residual site has a negative impact on the healing of a large number of tissue defects caused by tumor surgical resection. In recent years, with the deepening of research on biomaterials, the development of degradable biological platforms with therapeuti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C03C10/00C03C4/00A61K41/00A61P29/00A61P31/04A61P35/00B82Y40/00B82Y5/00
CPCC03C10/0009C03C4/0014C03C4/0021A61K41/0052A61P31/04A61P35/00A61P29/00B82Y40/00B82Y5/00
Inventor 雷波牛雯
Owner XI AN JIAOTONG UNIV
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