Biological fermentation production technology of hyaluronic acid

A bio-fermentation and production process technology, applied in the field of hyaluronic acid bio-fermentation production process, can solve the problems that restrict the production of hyaluronic acid, and achieve the effects of promoting accumulation, increasing production and promoting expression
CN107586810AInactive Publication Date: 2018-01-16成都远泓生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
成都远泓生物科技有限公司
Publication Date
2018-01-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a biological fermentation production technology of hyaluronic acid and belongs to the field of biological fermentation. The biological fermentation production technology of thehyaluronic acid, disclosed by the invention, comprises the following steps: activating strains, culturing a seed solution, carrying out amplified culture on the strains and carrying out fermentationculture. The fermentation culture is divided into a fermentation earlier stage and a fermentation later stage; the fermentation earlier stage and the fermentation later stage are applicable to self-growth of thalli and accumulation of the hyaluronic acid respectively. According to the production technology disclosed by the invention, a self-growth process of the thalli and a product expression process are separated relatively to realize the balance of self-metabolism of the thalli and product expression, so that the expression of the hyaluronic acid is promoted; nutrient components in a fermentation process are improved so that the growth of the thalli and the accumulation of the hyaluronic acid can be promoted better; a class index material supplementing manner is used for fermenting according to a growth principle of the thalli, so that the yield of the hyaluronic acid is improved.
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Description

technical field

[0001] The invention relates to the field of biological fermentation, in particular to a biological fermentation production process of hyaluronic acid. Background technique

[0002] Hyaluronic acid (HA), also known as hyaluronic acid, has a high degree of water retention, emollient and antibacterial protection, and is widely used as an additive in cosmetics. As a biochemical drug, HA is mainly used in the treatment of arthritis, ophthalmic viscosity surgery, soft tissue repair, and viscosity inhibitor after surgery. HA is an acidic mucopolysaccharide composed of D-glucuronic acid and acetylamino-D-glucose in a 1:1 molar ratio. In the inner wall of the plasma membrane, under the action of HA synthase, HA is synthesized from the two precursors of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) and uridine diphosphate-glucuronic acid (UDP-GlcA). HA has no species difference, regardless of the source, its structure and composition are the same, only the di...

Claims

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