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Carbon monoxide-containing hemoglobin preparation and applications of carbon monoxide-containing hemoglobin preparation in anti-inflammation

A technology of hemoglobin and carbon monoxide, applied in the direction of medical preparations containing active ingredients, anti-inflammatory agents, peptide/protein components, etc., can solve problems such as high toxicity, easy to cause immune rejection in organisms, and unsatisfactory anti-inflammatory effects

Inactive Publication Date: 2018-01-26
SHANGHAI GINPOSOME PHARMATECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The technical problem to be solved by the present invention is to overcome the carbon monoxide carrier commonly used in the prior art - carbon monoxide releasing molecule (CORM) anti-inflammation effect is not satisfactory and toxicity is relatively high, and it is easy to cause immune rejection in the organism, so there is still a lack of a The technical problem of carbon monoxide-containing preparations capable of effectively anti-inflammation, reducing immune rejection, and improving organism tolerance provides a hemoglobin preparation containing carbon monoxide and its application in anti-inflammation

Method used

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  • Carbon monoxide-containing hemoglobin preparation and applications of carbon monoxide-containing hemoglobin preparation in anti-inflammation
  • Carbon monoxide-containing hemoglobin preparation and applications of carbon monoxide-containing hemoglobin preparation in anti-inflammation
  • Carbon monoxide-containing hemoglobin preparation and applications of carbon monoxide-containing hemoglobin preparation in anti-inflammation

Examples

Experimental program
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Effect test

preparation Embodiment 1

[0119] Preparation Example 1 Preparation of the lyophilized powder of the hemoglobin preparation containing carbon monoxide

[0120] Draw carbon monoxide into the syringe, connect the syringe to the catheter, and pass the carbon monoxide directly into the aqueous solution containing hemoglobin through the catheter, so that the carbon monoxide saturation of the hemoglobin reaches 100%, freeze at -80°C for 24 hours, and then put it into a freeze dryer lyophilized for 24 hours to obtain the lyophilized powder of hemoglobin preparation containing carbon monoxide.

preparation Embodiment 2

[0121] Preparation Example 2 Prepare the solution of the porcine hemoglobin preparation containing carbon monoxide

[0122] The powder of the porcine hemoglobin preparation containing carbon monoxide prepared in Preparation Example 1 is dissolved in 5% glucose solution, so that the concentration of the hemoglobin preparation containing carbon monoxide is 2.94mmol / L, and the mmol / L is the hemoglobin per liter of the solution. The number of micromoles is the solution of the porcine hemoglobin preparation containing carbon monoxide, the percentage is mass volume percentage, and the unit is g / mL.

preparation Embodiment 3

[0123] Preparation Example 3 Preparation of Granules Containing Carbon Monoxide Bovine Hemoglobin Preparation

[0124] 1) Pass the powder of bovine hemoglobin preparation containing carbon monoxide prepared in Preparation Example 1 and sodium carboxymethyl cellulose through a 40-mesh sieve and mix them in a mass ratio of 5:95, add distilled water and mix evenly to obtain a soft material , the mass ratio of the distilled water to the powder of the carbon monoxide-containing bovine hemoglobin preparation and the total mass of the sodium carboxymethylcellulose is 5:95;

[0125] 2) Pass the soft material prepared in step 1) through a 20-mesh standard sieve, spread it evenly on a flat plate, and dry it in vacuum at 37°C to constant weight to obtain the granules of the bovine hemoglobin preparation containing carbon monoxide.

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Abstract

The present invention discloses a carbon monoxide-containing hemoglobin preparation and a preparation method thereof, applications of the carbon monoxide-containing hemoglobin preparation in preparation of anti-inflammatory drugs, an anti-inflammatory drug combination and a drug package, wherein the carbon monoxide-containing hemoglobin preparation comprises carbon monoxide-containing hemoglobin with a saturation degree of 20-100%. The preparation method comprises: introducing carbon monoxide into a hemoglobin-containing solution to achieve a saturation degree of 20-100%. According to the present invention, the carbon monoxide-containing hemoglobin preparation can control a variety of inflammatory reactions, has excellent anti-inflammatory effect, can effectively reduce the side effects ofthe existing similar drugs, can enhance the tolerance of receive objects, and further has advantages of convenience, low irritation and high safety.

Description

technical field [0001] The invention relates to the field of anti-inflammatory drugs, in particular to a hemoglobin preparation containing carbon monoxide and its application in anti-inflammation. Background technique [0002] The slow development of the inflammatory response gradually leads to a variety of seriously harmful diseases, such as the following inflammation-related diseases: asthma, adult respiratory distress syndrome, interstitial pulmonary fibrosis, pulmonary embolism, chronic obstructive pulmonary disease, primary pulmonary artery disease Hypertension, chronic emphysema, congestive heart failure, peripheral vascular disease, stroke, atherosclerosis, ischemia-reperfusion injury, heart attack, glomerulonephritis, conditions involving kidney inflammation, urogenital tract Infection, viral and toxic hepatitis, cirrhosis, intestinal obstruction, necrotizing enterocolitis, specific and nonspecific enteritis, rheumatoid arthritis, Alzheimer's disease, Parkinson's dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/42A61K33/00A61K47/42A61P29/00A61P31/00A61P9/10A61P1/04A61P37/06A61P19/02
Inventor 李翀毕秋艳王丹陈颖江詹华杏
Owner SHANGHAI GINPOSOME PHARMATECH CO LTD