Synthesis method of new ligand for efficient catalysis of CuAAC reaction

Abstract

Belonging to the technical field of synthesis of functional structural molecules, the invention discloses a synthesis method of a new ligand for efficient catalysis of CuAAC reaction. The key point ofthe technical scheme adopted by the invention lies in that: the synthesis method of the new ligand for efficient catalysis of CuAAC reaction includes: firstly synthesizing glycine methyl ester diyne,then taking glycine methyl ester diyne, an azido compound, K2CO3 and copper iodide as the raw materials, using acetonitrile and water as the solvent, carrying out stirring reaction at room temperature, and performing post-treatment at the end of reaction, thus obtaining the new ligand glycine methyl ester 1, 2, 3-ditriazole ring opening compound. The invention provides a variety of novel, efficient and easily available ligand catalysts for click reaction, as a ligand, the compound synthesized by the method provided by the invention has obvious effect of accelerating reaction and has a very practical application.

Description

technical field [0001] The invention belongs to the technical field of synthesizing functional structural molecules, and in particular relates to a synthesis method of a novel ligand that efficiently catalyzes CuAAC reaction. Background technique [0002] The Nobel Prize winner in Chemistry Sharpless, a chemist from the Scripps Research Institute in the United States, proposed the concept of "click" chemistry in 2001. Once the concept was proposed, it attracted widespread attention and became a hot spot of common concern in various disciplines of chemistry, life, medicine and materials at home and abroad. one. How to improve the biocompatibility of the click reaction and reduce the amount of Cu(I) has become a new trend of current research. [0003] There are two important research fields in click chemistry work today: one is copper-free catalyzed SPAAC reactions, and the other is ligand compounds that can coordinate and promote monovalent copper ions. The ligand has a ver...

AI Technical Summary

Problems solved by technology

[0004] In recent years, although compounds with one-valent copper ligands have been reported one after another, the demand for ligand research and development is far from enough for the wide application of click reactions.

In the past, for the synthesis of such ligands, the synthesis conditions often required expensive reaction raw materials, it was difficult to synthesize in large quantities, and the reaction conditions were relatively harsh.

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