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Roxithromycin capsule and preparation method thereof

A technology for roxithromycin and capsules, which is applied in the field of roxithromycin capsules and their production, can solve the problems of drug loss, drug efficacy reduction, drug waste and the like, and achieves good preparation stability, low cost, and reduced administration times. Effect

Inactive Publication Date: 2018-01-30
ANHUI YONSENT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Removing the capsule shell may cause drug loss, drug waste, and reduced drug efficacy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Roxithromycin capsules, the capsules include the following components by weight:

[0033] Roxithromycin 130 parts, cornstarch 40 parts, 5% polyvinylpyrrolidone aqueous solution 22 parts, talcum powder 3 parts.

[0034] The method for making described roxithromycin capsules is characterized in that: the method comprises the following steps:

[0035] Step 1 ingredients: weighing various raw materials;

[0036] Step 2 Granulation: dry mix the prepared raw and auxiliary materials in a mixing granulator for 3 minutes, add a binder to make a soft material, and granulate with a 24-mesh sieve;

[0037] Step 3 Drying: Dry the prepared wet granules in a high-efficiency boiling dryer at a constant temperature for 20 minutes;

[0038] Step four granulation and total mixing: the dried granules are sieved through a 24-mesh sieve for granulation, add talcum powder and mix in a three-dimensional motion mixer for 15 minutes;

[0039] Step five capsule filling;

[0040] Step 6 Alumin...

Embodiment 2

[0050] Roxithromycin capsules, the capsules include the following components by weight:

[0051] Roxithromycin 170 parts, cornstarch 50 parts, 5% polyvinylpyrrolidone aqueous solution 28 parts, talcum powder 8 parts.

[0052] The method for making described roxithromycin capsules is characterized in that: the method comprises the following steps:

[0053] Step 1 ingredients: weighing various raw materials;

[0054] Step 2 Granulation: dry mix the prepared raw and auxiliary materials in a mixing granulator for 3 minutes, add a binder to make a soft material, and granulate with a 24-mesh sieve;

[0055] Step 3 Drying: Put the prepared wet granules in a high-efficiency boiling dryer and dry them at a constant temperature for 20-30 minutes;

[0056] Step four granulation and total mixing: the dried granules are sieved through a 24-mesh sieve for granulation, add talcum powder and mix in a three-dimensional motion mixer for 15 minutes;

[0057] Step five capsule filling;

[005...

Embodiment 3

[0068] Roxithromycin capsules, the capsules include the following components by weight:

[0069] Roxithromycin 140 parts, cornstarch 42 parts, 5% polyvinylpyrrolidone aqueous solution 24 parts, talcum powder 4 parts.

[0070] The method for making described roxithromycin capsules is characterized in that: the method comprises the following steps:

[0071] Step 1 ingredients: weighing various raw materials;

[0072] Step 2 Granulation: dry mix the prepared raw and auxiliary materials in a mixing granulator for 3 minutes, add a binder to make a soft material, and granulate with a 24-mesh sieve;

[0073] Step 3 Drying: Put the prepared wet granules in a high-efficiency boiling dryer and dry them at a constant temperature for 20-30 minutes;

[0074] Step four granulation and total mixing: the dried granules are sieved through a 24-mesh sieve for granulation, add talcum powder and mix in a three-dimensional motion mixer for 15 minutes;

[0075] Step five capsule filling;

[0076]...

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PUM

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Abstract

The invention relates to a roxithromycin capsule and a preparation method thereof. The roxithromycin capsule is prepared from, by weight, 130-170 parts of roxithromycin, 40-50 parts of corn starch, 22-28 parts of 5% of a polyvinyl pyrrolidone aqueous solution and 3-8 parts of talcum powder. The method includes blending, granulating, drying, size stabilizing, total blending, capsule filling, aluminum plastic packaging, external packaging and storage. The formula of the roxithromycin capsule and the preparation method of the capsule are favorable for improving inner quality and quality control level of crude drugs of roxithromycin.

Description

technical field [0001] The invention relates to the field of medicine and chemical industry, in particular to a roxithromycin capsule and a preparation method thereof. Background technique [0002] Roxithromycin is the first generation of semi-synthetic macrolide antibiotics, and its antibacterial spectrum and antibacterial effect are similar to erythromycin. It mainly acts on Gram-positive bacteria, anaerobic bacteria, chlamydia and mycoplasma, etc. Roxithromycin Roxithromycin is acid-resistant and not damaged by gastric acid. It is well absorbed from the gastrointestinal tract and has a high blood concentration (the peak blood concentration of roxithromycin is the highest among all macrolides). It is suitable for the treatment of pharyngitis and tonsillitis caused by Streptococcus pyogenes; the treatment of sinusitis, otitis media, acute bronchitis, and acute exacerbation of chronic bronchitis caused by sensitive bacteria; it is suitable for the treatment of pneumonia cau...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K31/7048A61K47/36A61P31/04
Inventor 夏运喜程玉柱刘翠玲
Owner ANHUI YONSENT PHARMA