2-(4-Morpholino)-4,6-disubstituted pyrimidine/s-triazine compounds, salts thereof, and application of compounds or salts
A disubstituted, morpholino-based technology, applied to 2--4,6-disubstituted pyrimidine or s-triazine compounds and their pharmaceutically acceptable salts and application fields, can solve problems such as poor clinical effects, and achieve anti-inflammatory properties. Good tumor activity
Inactive Publication Date: 2018-02-02
XI AN JIAOTONG UNIV
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Abstract
The invention relates to 2-(4-morpholino)-4,6-disubstituted pyrimidine/s-triazine compounds, salts thereof, and an application of the compounds or the salts. The above disclosed 2-(4-morpholino)-4-(N-(1-benzoyl-4-piperidyl)amino)-6-(pyridyl or pyrimidinyl)pyrimidine or s-triazine compounds have a general formula shown in the description; and in the formula, X and Y are N or CH, R<1> is a C1-C3 alkyl group, R<2> is hydrogen, halogen, a methyl group or a trifluoromethyl group, R<3> is an amino group, a methoxy group, a cyano group or a trifluoromethyl group, and X is not N when the R<2> is hydrogen, R<3> is the amino group and Y is N. The compounds and the salts have PI3K and RAF kinase inhibition dual activity, can simultaneously inhibit a PI3K/AKT/mTOR signal transduction pathway and an Ras/RAF/MEK/ERK signal transduction pathway, and have good antitumor activity. The invention also discloses a use of the compounds of the general formula as a PI3K//RAF dual inhibitor.
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Organic active ingredientsOrganic chemistry +1
Technology Topic
TrifluoromethylPyrimidine +10
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