Method for dissociating iron coordination polymer nanoparticles and application thereof

A technology of coordination polymers and nanoparticles, applied in the field of biomedical new materials, can solve the problems of poor tumor accumulation and retention, affect the treatment effect, and do not have the EPR effect, and achieve the effect of reducing potential damage

Active Publication Date: 2018-02-09
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, although smaller molecules or nanoparticles cannot be captured by endothelial reticulum cells, they can achieve rapid renal clearance and reduce toxic sid

Method used

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  • Method for dissociating iron coordination polymer nanoparticles and application thereof
  • Method for dissociating iron coordination polymer nanoparticles and application thereof
  • Method for dissociating iron coordination polymer nanoparticles and application thereof

Examples

Experimental program
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preparation example Construction

[0053] The invention provides a method for preparing iron coordination polymer nanoparticles, comprising:

[0054] Coordinating high molecular polymers, ferric salts and polyphenols to obtain coordination polymer nanoparticles.

[0055] The preparation method of the iron coordination polymer nanoparticles of the present invention is to react and coordinate the high molecular polymer, ferric salt and polyphenol to obtain the coordination polymer nanoparticles; preferably specifically:

[0056] The high molecular polymer and the ferric salt are mixed and stirred, then polyphenol is added, stirred, centrifuged, and ultrasonically dispersed to obtain polymer nanoparticles.

[0057] Firstly, a high molecular polymer is provided or prepared, which has been clearly described above, and will not be repeated here.

[0058] In the invention, firstly, the high molecular polymer and the ferric salt are mixed and stirred. Preferably, the polyethylene glycol-modified polyglutamic acid is ...

Embodiment 1～16

[0091] The molecular weights of polyethylene glycol and polyglutamic acid were respectively selected to be 5000Da and 21600Da, and the molar ratio was 5:1. Dissolve polyethylene glycol-modified polyglutamic acid in water, add ferric chloride solution, mix and stir for 4 hours, and slowly add polyphenol dropwise under rapid stirring at a rate of 0.5mL / min, and add polyphenol The final mixing and stirring time is 12h. Centrifuge after the mixing and stirring, the centrifugal speed is selected as 8000rpm, and the centrifugal time is selected as 10min. After ultrasonic dispersion, coordination polymer nanoparticles were prepared. The types and amounts of polyethylene glycol, polyglutamic acid, ferric chloride, and polyphenols are shown in Table 1.

[0092] The consumption of table 1 embodiment 1~16 different raw materials

[0093]

[0094] The coordination polymer nanoparticles prepared in Example 6 were analyzed, and the results showed that the average size of the iron coor...

Embodiment 17～29

[0096] 1.2 mL of iron coordination polymer nanoparticles with a concentration of 2 mg / mL were added with different volumes of deferoxamine with a concentration of 50 mg / mL, and stirred for a certain period of time. Watch its color change and track its UV and particle size changes. Wherein, the concentration and stirring time of adding deferoxamine are as follows:

[0097] Table 2 embodiment 17~29 adds the concentration and stirring time of ferric amine

[0098]

[0099] The color change of iron coordination polymer nanoparticles before and after dissociation in Example 25 is as follows: figure 1 . The results showed that with the increase of the volume of deferoxamine, the iron coordination polymer nanoparticles gradually became lighter from the original black color, and the color gradually changed to brownish yellow as time went on. Among them, the ultraviolet changes before and after the dissociation were further detected, and the results showed that the ultraviolet ab...

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Abstract

The invention provides a method for dissociating iron coordination polymer nanoparticles. The method comprises the steps that the iron coordination polymer nanoparticles are dissociated by a dissociation agent which is one or more selected from a group consisting of deferoxamine, deferiprone, ethylenediamine tetraacetic acid and ethylenediamine tetraacetic acid disodium salt. The iron coordinationpolymer nanoparticles are prepared from polyphenol, trivalent iron salt and macromoleclar polymer. The special dissociation agent is adopted to dissociate the iron coordination polymer nanoparticles.Under the action of the dissociation agent, the iron coordination polymer nanoparticles can be quickly dissociated into small nanoparticles or a small molecular solution. The dissociating method canquickly remove the iron coordination polymer nanoparticles in vivo and particularly the iron coordination polymer nanoparticles at the position of the liver, and reduce potential damage to the liver.

Description

technical field [0001] The invention relates to the technical field of biomedical new materials, in particular to a dissociation method of iron coordination polymer nanoparticles. Background technique [0002] At present, for the treatment of tumors, the commonly used nanoparticles with photothermal function are: Fe 3 o 4 、 Bi 2 Se 3 、MoS 2 etc. These nanoparticles have the EPR effect, can achieve good aggregation at the tumor, and have good imaging functions. Such nanoparticles have the advantages of multifunctionality, such as photothermal function Bi 2 Se 3 Nanoparticles can guide the photothermal treatment of tumors while imaging tumors in multiple modes, and realize accurate diagnosis and treatment of tumors. However, due to the EPR effect, nanoparticles accumulate in the tumor and also retain a large amount in endoplasmic reticulum tissues such as the liver, which will cause certain damage to the liver. [0003] At present, most nanomaterials accumulate in the l...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K49/22A61K49/12A61P35/00
CPCA61K41/0052A61K49/12A61K49/22
Inventor 田华雨王艳兵徐彩娜陈学思
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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