Photo-cross-linking nano-epoxy resin and preparation method thereof

Abstract

The present invention is a kind of photocrosslinking nanometer epoxy resin, and its effective composition is the carboxymethyl chitosan derivative that ultraviolet light triggers azido group crosslinking, and it is made by following method: take carboxymethyl chitosan Aqueous solution, according to the molar ratio of the sugar unit of carboxymethyl chitosan to 4-azidobenzaldehyde is 1: (0.01-10), add the organic solution of 4-azidobenzaldehyde, and stir and mix at 0-30°C in the dark Uniform, while reacting to generate photocrosslinkable carboxymethyl chitosan amphiphilic polymer, the amphiphilic polymer will self-assemble into photocrosslinkable nanoparticle mixed solution; then, the nanoparticle The mixed solution is irradiated with ultraviolet light to initiate azido crosslinking. The process of the invention is simple and easy to operate. Not only can the photocrosslinked targeting nanogel be obtained by carboxyl complexing target molecules or target molecule derivatives, but also it can be used in tissue engineering, biomedical implants, bionanotechnology and drug delivery. System and other fields have potential application value.

Description

technical field [0001] The invention relates to a gel material, in particular to a method for preparing a photocrosslinked nano-epoxy resin. Background technique [0002] Nanogel is a microgel with a size ranging from 10 to 1000 nanometers. It not only has high water content, good biocompatibility and adjustable chemical and mechanical properties, but also high specific surface area can couple biomacromolecules, cross-linked network can coat therapeutic molecules, and adjustable particle size facilitates regulation its distribution in the body. These properties lead to the broad application potential of nano-epoxy resins in tissue engineering, biomedical implants, bionanotechnology and drug delivery systems. Although there are many methods for preparing nanogels, and different methods produce gels with different particle sizes and surface structures, resulting in different uses, they can still be divided into two methods: physical and chemical. The physical method is to u...

AI Technical Summary

Problems solved by technology

However, compared to chitosan, the preparation of carboxymethyl chitosan nano-epoxy resin has not been reported yet.

[0005] The main defect that above-mentioned chemical cross-linking method prepares chitosan nano-epoxy resin is:

[0006] (1) In-situ drug loading cannot be achieved for drugs or active molecules with amine groups, because the cross-linking agent is easy to chemically react with the amine groups on the drug or active molecules

[0007] (2) The preparation process is more complicated, and toxic cross-linking agents such as glutaraldehyde must be removed by dialysis and other methods

[0009] Although the physical cross-linking method can avoid some defects of the chemical cross-linking method, its stability, especially in the internal environment of the human body, is not as good as that of the chemical cross-linking method, which will lead to premature rupture of the nanogel, and premature release of the drug or active agent. freed

In addition, the nanogel obtained by physical cross-linking has a wide particle size distribution and is easy to aggregate.

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