A method for measuring contents of 14 chemical components in a traditional Chinese medicine composition
A technology for chemical components and compositions, applied in the field of determination of the contents of 14 chemical components in traditional Chinese medicine compositions, can solve the problems of quality control, numerous compound components, and complicated preparation processes, and achieve strong reliability, effective quality control, and sensitivity. high effect
Active Publication Date: 2018-02-16
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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At present, the method used for quality control of Tongmai Yangxin is mainly HPLC method. For example, Yan Weiwei used HPLC method to determine the amount of glycyrrhizic acid in Tongmai Yangxin pills, and Xu Daoqing used HPLC method to determine the content of Schisandra Alcohol A in Tongmai Yangxin pills. However, Tongmai Yangxin Pills has many medicinal flavors, complex preparation process, and many chemical components. Controlling only one chemical composition cannot effectively control its quality. Therefore, a new chemical composition of Tongmai Yangxin Pills is needed. Composition determination method, in order to be able to carry out quality control on Tongmai Yangxin Pills more credibly and comprehensively
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[0040] Tongmai Yangxin Pills are mainly composed of 11 traditional Chinese medicines including rehmannia glutinosa, Caulis Spatholobus, Ophiopogon japonicus, licorice, Polygonum multiflorum, Donkey-hide gelatin, Schisandra chinensis, Codonopsis pilosula, vinegar tortoise shell, jujube and osmanthus twig. According to literature records, Tongmai Yangxin Pills contain 14 chemical components related to their efficacy, including: emodin, tangshenoside, stilbene glycoside, glycyrrhizic acid, liquiritin, liquiritin, polydatin, rutin, Isoliquiritigenin, formononetin, verbascoside, gallic acid, schisandrin A, rhein. Among these chemical components (also known as active ingredients), if the content of any chemical component is too high or too low, the clinical curative effect of the medicine will be affected. For the clinical curative effect of Yangxin Pills, only by comprehensively measuring the content of the above 14 chemical components, can the quality control of Tongmai Yangxin Pi...
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A method for measuring contents of 14 chemical components in a traditional Chinese medicine composition is disclosed. HPLC-MS/MS is adopted to simultaneously measure the contents of the 14 chemical components in the composition. The composition is a pulse-invigorating heart-tonifying pill. The 14 chemical components include emodin, lobetyolin, 2,3,5,4'-tetrahydroxy stilbene-2-O-beta-D-glucoside, glycyrrhizic acid, liquiritin, liquiritigenin, polydatin, rutoside, isoliquiritigenin, ononin, verbascoside, gallic acid, schizandrin, and rhein. The method includes building standard curves of the 14chemical components; acquiring multi-reaction ion chromatograms of the 14 chemical components in the pill; and determining the contents of the 14 chemical components in the pill. The method has characteristics of high sensitivity, high reliability, a high efficiency and capability of being rapid. Through measuring the contents of the 14 chemical components in the pill, quality control on the pillcan be more effectively performed, thus ensuring clinical treatment effects of the pill.
Description
technical field [0001] The invention relates to the field of quality analysis of traditional Chinese medicines, in particular to a method for measuring the contents of 14 chemical components in a Chinese medicine composition. Background technique [0002] Tongmai Yangxin Pill comes from Zhigancao Decoction in Zhang Zhongjing's "Treatise on Febrile and Miscellaneous Diseases". It was developed by Dong Xiaochu, an old Chinese medicine doctor, based on this prescription. Tongmai Yangxin Pills are mainly used to treat chest obstruction and heartache, palpitations, angina pectoris and arrhythmia. It is mainly composed of 11 traditional Chinese medicines such as rehmannia glutinosa, Caulis Spatholobus, Ophiopogon japonicus, licorice, fleece-flower root, donkey-hide gelatin, schisandra, codonopsis, vinegar tortoise shell, jujube, and cinnamon sticks. At present, the method used for quality control of Tongmai Yangxin is mainly HPLC method. For example, Yan Weiwei used HPLC method t...
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IPC IPC(8): G01N30/88G01N30/06
CPCG01N30/06G01N30/88
Inventor 何俊张丹丹欧阳慧子常艳旭郝佳刘二伟
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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