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Chinese-Western compound preparation for treating senile dementia and preparation method thereof

A technology for senile dementia and compound preparations, applied in the field of medicine, can solve the problems of inability to delay the development of the disease, liver and kidney toxicity of western medicine, and insignificant curative effect, and achieve the effects of low side effects, broad medical application prospects, and improvement of insomnia and forgetfulness

Inactive Publication Date: 2018-02-23
王君
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many western medicines for the treatment of senile dementia. These medicines can only temporarily alleviate the cognitive decline of patients, but cannot delay the development of the disease. Moreover, western medicines have serious adverse reactions such as liver and kidney toxicity, and are expensive.
In recent years, experts and scholars at home and abroad have begun to pay attention to natural traditional Chinese medicine. Traditional Chinese medicine has the advantages of strong long-term effect, strong drug resistance, safety and non-toxicity. Alzheimer's Drugs

Method used

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  • Chinese-Western compound preparation for treating senile dementia and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0020] A preparation method of a Chinese-Western compound preparation for treating senile dementia, comprising the steps of:

[0021] S1: 23 parts of Rehmannia glutinosa, 23 parts of lavender, 14 parts of Panax notoginseng, 14 parts of Puhuang, 14 parts of curculigo, 16 parts of Polygonum multiflorum, and 16 parts of Chuanpu are made into pieces, decocted with water for 3 times, filtered, and combined The filtrate, the filtrate is concentrated under reduced pressure to 3 times the amount of the raw material, added ethanol with a mass concentration of 60-70%, rested for 24-48 hours, removed the supernatant, precipitated, concentrated and dried under reduced pressure, and pulverized into a fine powder for later use;

[0022] S2: Grinding 1.8 parts of hydroergot alkaloid and 2 parts of ifenprodil into fine powder 2;

[0023] S3: Mix the fine powder 2 obtained in step S2 with the fine powder 1 obtained in step S1, add sodium carboxymethyl starch, dextrin, and magnesium stearate, m...

Embodiment 2

[0025] A preparation method of a Chinese-Western compound preparation for treating senile dementia, comprising the steps of:

[0026] S1: Make 28 parts of Rehmannia glutinosa, 30 parts of lavender, 18 parts of Panax notoginseng, 18 parts of Puhuang, 18 parts of curculigo, 20 parts of Polygonum multiflorum, and 20 parts of Chuanpu into pieces, add water to decoct 3 times, filter, and combine The filtrate, the filtrate is concentrated under reduced pressure to 3 times the amount of the raw material, added ethanol with a mass concentration of 60-70%, rested for 24-48 hours, removed the supernatant, precipitated, concentrated and dried under reduced pressure, and pulverized into a fine powder for later use;

[0027] S2: Grinding 2.5 parts of hydroergot alkaloid and 2.8 parts of ifenprodil into fine powder 2;

[0028] S3: Mix the fine powder 2 obtained in step S2 with the fine powder 1 obtained in step S1, add sodium carboxymethyl starch, dextrin, and magnesium stearate, mix evenly...

Embodiment 3

[0030] A preparation method of a Chinese-Western compound preparation for treating senile dementia, comprising the steps of:

[0031] S1: Make 35 parts of Rehmannia glutinosa, 35 parts of lavender, 22 parts of Panax notoginseng, 22 parts of Puhuang, 22 parts of curculigo, 25 parts of Polygonum multiflorum, and 25 parts of Chuanpu into pieces, add water to decoct 3 times, filter and combine The filtrate, the filtrate is concentrated under reduced pressure to 3 times the amount of the raw material, added ethanol with a mass concentration of 60-70%, rested for 24-48 hours, removed the supernatant, precipitated, concentrated and dried under reduced pressure, and pulverized into a fine powder for later use;

[0032] S2: Grinding 3.5 parts of hydroergot alkaloid and 3.5 parts of ifenprodil into fine powder 2;

[0033] S3: Mix the fine powder 2 obtained in step S2 with the fine powder 1 obtained in step S1, add sodium carboxymethyl starch, dextrin, and magnesium stearate, mix evenly,...

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Abstract

A Chinese-Western compound preparation for treating senile dementia and a preparation method thereof. The Chinese-Western compound preparation is compounded by Chinese medicine ingredients and Western medicine ingredients, and the Chinese medicine ingredients include the following raw materials in parts by weight: Rehmannia glutinosa 23‑35 23-35 parts of Lavender, 14-22 parts of Panax notoginseng, 14-22 parts of Puhuang, 14-22 parts of curculigo, 16-25 parts of Polygonum multiflorum, 16-25 parts of Chuanpu; the western medicine components include the following raw materials : Hydroergot 1.8-3.5 parts, Ifenprodil 2-3.5 parts. The Chinese-Western compound preparation of the present invention combines a variety of selected Chinese herbal medicines and Western medicines to synergistically enhance the therapeutic efficacy of Alzheimer's disease, effectively improve the functions of brain nerves, cerebral blood vessels and cerebral blood circulation, and improve and treat Alzheimer's disease-induced diseases. For insomnia, forgetfulness, memory loss, cognitive decline, etc., the course of treatment is short, the effect is quick, and the side effects are low, so it has broad medical application prospects.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a Chinese-Western compound preparation for treating senile dementia and a preparation method thereof. Background technique [0002] As the pace of the world's aging society continues to accelerate, various neurodegenerative senile diseases, such as mild cognitive impairment and senile dementia, have become important risk factors that threaten human health in old age and reduce the quality of life of the elderly. It has brought serious economic burden and heavy mental pressure to society and family. Alzheimer's disease can be divided into Alzheimer's disease (AD), vascular dementia (VD), mixed dementia (AD+VD) and other dementias. It is a persistent high-level neurological activity disorder, clinically manifested as deteriorating cognitive and memory functions, progressive decline in the ability of daily life, and various neuropsychiatric symptoms and behavioral diso...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61P25/28A61K31/48A61K31/445
CPCA61K36/88A61K31/445A61K31/48A61K36/258A61K36/53A61K36/575A61K36/704A61K36/804A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 王君
Owner 王君
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