Chitosan-based bleeding stopping paste as bone wax substitute, and preparation method thereof

Abstract

The invention discloses a chitosan-based bleeding stopping paste as a bone wax substitute, and a preparation method thereof. The preparation method comprises: dissolving carboxymethyl chitosan with aviscosity average molecular weight of 100000-150000 and a substitution degree of 50-150% in distilled water, adding chitosan with a viscosity average molecular weight of 100000-300000 and a deacetylation degree of more than 85%, and calcium alginate, uniformly stirring, sealing, and sterilizing with ethylene oxide. According to the present invention, the chitosan-based bleeding stopping paste hasstrong plasticity, can block bone cross-sections or any tissue gaps, and further has the bleeding stopping function, wherein the bone wax does not have the bleeding stopping function; the chitosan-based bleeding stopping paste can rapidly stop the bleeding of venous hemorrhage and capillary hemorrhage models; and CM-CS, CS and Al are natural polymer derivatives, can be completely degraded, and have good antibacterial properties, such that the postoperative infection can be reduced, and the risk of chronic inflammation and other adverse reactions can be reduced.

Description

Technical field [0001] The invention belongs to the field of medicine, and particularly relates to a chitosan-based hemostatic paste and a preparation method. Background technique [0002] Bone wax is a functional plugging agent used in orthopedics, neurosurgery, cardiothoracic surgery and dental surgery to stop bleeding in special locations. The clinical hemostatic effect of bone wax is relatively clear. R Middleton et al. reported that the use of bone wax to seal the osteotomy surface and bone hole in total hip arthroplasty (THA) can significantly reduce postoperative bleeding [1] . However, Yushan [2] Research by others believes that patients who use bone wax will have different degrees of chronic inflammation in the local area, which stimulates the proliferation of surrounding tissues to surround the wax block. ClaudioSchonauer et al [3] It is recommended that bone wax be used only when necessary during surgery, the amount is sufficient to achieve hemostasis, and the excess...

AI Technical Summary

Problems solved by technology

Due to the strong nature of CS, it is easy to make dressings such as film, powder, sponge, and fiber, but it has not been reported that it can not only play the role of mechanical packing of the osteotomy surface but also play the role of hemostasis as a paste.

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