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Preparation method of chemical/ionic double-crosslinking interpenetration network hydrogel

An interpenetrating network and ionic cross-linking technology, which is applied in the field of preparation of high-strength chemical/ionic double cross-linked interpenetrating network hydrogels, can solve problems such as hydrogel instability, and achieve improved mechanical properties and biocompatibility properties, mild reaction conditions, and excellent mechanical properties

Active Publication Date: 2018-02-23
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional preparation method is to cross-link sodium alginate with calcium ions to form a hydrogel, which is convenient and quick, but the hydrogel is unstable in buffer systems or saline solutions

Method used

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  • Preparation method of chemical/ionic double-crosslinking interpenetration network hydrogel
  • Preparation method of chemical/ionic double-crosslinking interpenetration network hydrogel
  • Preparation method of chemical/ionic double-crosslinking interpenetration network hydrogel

Examples

Experimental program
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Effect test

Embodiment 1

[0031] The specific preparation method is as follows: (1) Weigh 0.01mol 4-chloromethylstyrene (VC) and 0.01mol acrylamide into a three-necked flask containing 5mL N,N-dimethylformamide, magnetically stir and mix evenly, Add 0.015g of azobisisobutyronitrile, under the protection of nitrogen, heat, stir and reflux in an oil bath at 65°C for 12 hours. After the reaction, transfer the viscous liquid to a beaker and dry it in vacuum at 60°C for 8 hours. Polymer A was obtained after repeated washing and drying of ether.

[0032] (2) Weigh 0.01mol 1-vinylimidazole (VM), 0.01mol acrylamide and 0.02mol 1-(4-vinylbenzyl)-3-methylimidazole In a three-necked flask of methylformamide, magnetically stir and mix evenly, add 0.015g of azobisisobutyronitrile, under the protection of nitrogen, heat and stir in an oil bath at 65°C for reflux reaction for 12h, after the reaction, transfer the viscous liquid to In a beaker, vacuum-dry at 60°C for 8 hours, and the dried product is repeatedly washe...

Embodiment 2

[0035] The specific preparation method is: (1) Weigh 0.01mol 4-chloromethylstyrene (VC) and 0.02mol N,N-dimethylacrylamide into a three-necked flask containing 6mL N,N-dimethylformamide , stir and mix evenly with magnetic force, add 0.015g of azobisisobutyronitrile, under the protection of nitrogen, heat, stir and reflux in an oil bath at 65°C for 12 hours, transfer the viscous liquid to a beaker after the reaction, and vacuum at 60°C After drying for 8 hours, the dried product was repeatedly washed and dried with petroleum ether to obtain polymer A.

[0036](2) Weigh 0.01mol 1-vinylimidazole (VM), 0.02mol N,N-dimethylacrylamide and 0.04mol 1-(4-vinylbenzyl)-3-methyl imidazole chloride into the In a three-neck flask of 12mL N,N-dimethylformamide, magnetically stir and mix evenly, add 0.02g of azobisisobutyronitrile, under the protection of nitrogen, heat, stir and reflux in an oil bath at 65°C for 12h, after the reaction The viscous liquid was transferred to a beaker and drie...

Embodiment 3

[0039] The specific preparation method is as follows: (1) Weigh 0.01mol 4-chloromethylstyrene (VC) and 0.05mol acrylamide into a three-necked flask containing 10mL N,N-dimethylformamide, magnetically stir and mix evenly, Add 0.02g of azobisisobutyronitrile, under the protection of nitrogen, heat, stir and reflux in an oil bath at 65°C for 16 hours. After the reaction, transfer the viscous liquid to a beaker and dry it in vacuum at 60°C for 8 hours. Polymer A was obtained after repeated washing and drying of ether.

[0040] (2) Weigh 0.01mol 1-vinylimidazole (VM), 0.02mol acrylamide and 0.03mol 1-(4-vinylbenzyl)-3-methylimidazole In a three-necked flask of methylformamide, magnetically stir and mix evenly, add 0.02g of azobisisobutyronitrile, under the protection of nitrogen, heat and stir in an oil bath at 65°C for reflux reaction for 16h, and transfer the viscous liquid to In a beaker, vacuum-dry at 60°C for 8 hours, and the dried product is repeatedly washed and dried with ...

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Abstract

The invention provides a preparation method of chemical / ionic double-crosslinking interpenetration network hydrogel. The method comprises the steps that firstly, 4-vinylbenzyl chloride and hydrophiliamonomer A (acrylamide, N,N-dimethylacrylamide or N-isopropylacrylamide) are subjected to copolymerization through free radicals to obtain polymer A, then 1-vinyl imidazole, hydrophilia monomer A andmonomer B with imidazole positive ions (unsaturation hydrocarbon with imidazole positive ions) are subjected to copolymerization to obtain polymer B, and then the solution of the polymer A and the polymer B is evenly mixed with sodium alginate aqoeous solution, heated, subjected to coupling reaction so that the aim of chemical / ionic double-crosslinking can be achieved. The prepared hydrogel is excellent in mechanical property, contains the imidazole positive ions, has the antibacteria characteristic, can load negative ions through ion exchange, and has potential application values in the fields of biomedicine (such as medicine slow control and release and bacteria resistance) and light industry (such as catalysis of loaded metal particles).

Description

technical field [0001] The invention relates to an interpenetrating network hydrogel, in particular to a preparation method of a high-strength chemical / ionic double cross-linked interpenetrating network hydrogel containing imidazolium cations. Background technique [0002] Hydrogel is a functional polymer material with hydrophilic groups and three-dimensional network structure, which can store a large amount of water. Hydrogels are widely used in biomedicine, light industry and other fields due to their advantages of high water absorption, good biocompatibility and environmental friendliness. Due to the large amount of water contained in traditional hydrogels, their mechanical properties are poor, which severely restricts their application range. [0003] The double network structure hydrogel refers to the fact that the hydrogel contains two interpenetrating networks, generally including a rigid polymer network with a high cross-linking density and a flexible polymer networ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L25/18C08L5/04C08L33/24C08L33/26
CPCC08J3/075C08J3/246C08J2325/18C08J2333/26C08J2333/24C08J2405/04C08J2425/18
Inventor 王文嫔姚青孙帅王子秋宋以法李志波
Owner QINGDAO UNIV OF SCI & TECH
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