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Orally disintegrating tablet containing donepezil hydrochloride and preparation method thereof

A technology of donepezil hydrochloride and orally disintegrating tablets, which is applied to medical preparations containing active ingredients, medical preparations without active ingredients, and pharmaceutical formulas, etc. It can solve the problems of low hardness, poor taste, and low friability of plain tablets , to achieve the effect of low friability, low production cost and good compressibility

Active Publication Date: 2018-03-13
CHENGDU KANGHONG PHARMA GRP
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to overcome the technical problems of low hardness, low friability, and poor taste of plain tablets in donepezil hydrochloride orally disintegrating tablets in the prior art, the present invention provides an orally disintegrating tablet containing donepezil hydrochloride, which contains the following weight percent The components of:

Method used

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  • Orally disintegrating tablet containing donepezil hydrochloride and preparation method thereof
  • Orally disintegrating tablet containing donepezil hydrochloride and preparation method thereof
  • Orally disintegrating tablet containing donepezil hydrochloride and preparation method thereof

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Embodiment 1-14

[0091] Embodiment 1-14 (by the percentage of total prescription volume):

[0092]

[0093]

[0094] Preparation method: first weigh the prescription amount of donepezil hydrochloride, croscarmellose sodium, and peppermint essence to pass through a 60-mesh sieve for later use, and weigh the prescription amount of mannitol, microcrystalline cellulose, magnesium stearate, and silicon dioxide respectively. Pass through 40 mesh for later use, weigh the prescribed amount of sucralose and crush it and pass through 80 mesh for later use; then mix the sieved donepezil hydrochloride with sucralose and peppermint essence and pass through a 40 mesh sieve once, then deliver it to the same amount of microcrystalline cellulose Add and mix and pass through a 40-mesh sieve once, then transfer to a mixer and mix with the remaining materials evenly, and then discharge, the tablet weight is 150mg.

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Abstract

The invention provides an orally disintegrating tablet containing donepezil hydrochloride and a preparation method thereof. The orally disintegrating tablet comprises donepezil hydrochloride, mannitol, microcrystalline cellulose, and a disintegrating agent. By controlling the using amounts of mannitol and microcrystalline cellulose, the orally disintegrating tablet having the advantages of rapid disintegration, low friability, good taste, and simple technology is obtained.

Description

technical field [0001] The invention relates to an orally disintegrating tablet containing donepezil hydrochloride and a preparation method thereof, in particular to an orally disintegrating tablet with donepezil hydrochloride as the main ingredient and a preparation method thereof. Background technique [0002] Donepezil Hydrochloride is a light yellow or yellow powder or crystal, odorless, bitter in taste, and strong hygroscopicity. It is a second-generation cholinesterase inhibitor (AChEI) for the treatment of Alzheimer's disease. Acetylcholinesterase has strong selectivity. It increases the content of acetylcholine in the brain of animals by inhibiting acetylcholinesterase, so that the content of acetylcholine in the synapses directly involved in neurotransmission increases, resulting in a therapeutic effect and can improve learning disabilities. Acetylcholine ester in the heart and intestines The enzyme has almost no inhibitory effect, so it has the characteristics of s...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/445A61K47/26A61K47/38A61K47/46A61K47/12A61K47/04A61P25/28
CPCA61K9/0056A61K9/2009A61K9/2013A61K9/2018A61K9/2054A61K9/2068A61K31/445
Inventor 柯潇郑强严莉容
Owner CHENGDU KANGHONG PHARMA GRP
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