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Compound pharmaceutical composition containing piperacillin and applications thereof

A technology of piperacillin and composition, which is applied in the field of pharmaceutical compositions containing piperacillin to achieve the effect of excellent antibacterial activity

Active Publication Date: 2018-03-13
XIANGBEI WELMAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The combination of avibactam and other β-lactam antibiotics has not been reported

Method used

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  • Compound pharmaceutical composition containing piperacillin and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Piperacillin sodium 1000g, avibactam sodium 125g, pulverized under aseptic conditions (jet mill), mixed together (single-cone spiral mixer), and packed to obtain piperacillin sodium acitret Pharmaceutical composition of batan sodium.

Embodiment 2

[0040] Piperacillin sodium 1200g, avibactam sodium 300g, dissolved in water to form a solution, placed in a freeze dryer for lyophilization operation, to obtain a pharmaceutical composition of piperacillin sodium and avibactam sodium.

Embodiment 3-9

[0042] According to the method of Example 1, multiple batches of piperacillin sodium and avibactam sodium pharmaceutical compositions with different active ingredient ratios were prepared. In Examples 3-9, the dosages of piperacillin sodium and avibactam sodium were 900g and 450g, 700g and 700g, 500g and 600g, 300g and 600g, 200g and 1000g, 200g and 1440g, and 100g and 900g.

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PUM

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Abstract

The invention provides a compound pharmaceutical composition containing piperacillin and applications thereof. The active component of the compound pharmaceutical composition is composed of piperacillin and avibactam, and piperacillin and avibactam are both in a solid form. The provided pharmaceutical composition has excellent antibacterial activity and very good effect on killing drug resistant streptococcus pneumonia. Compared with a conventional piperacillin product, the curative effect is improved by dozens of times.

Description

Technical field [0001] The invention relates to a pharmaceutical composition containing piperacillin. The invention also relates to the application of the pharmaceutical composition in medicine. Background technique [0002] Piperacillin is a penicillin antibiotic commonly used clinically, and its sodium salt is the main medicinal form. Piperacillin sodium can be used to treat sepsis caused by Enterobacteriaceae bacteria, Pseudomonas aeruginosa, Acinetobacter, etc., upper urinary tract and complicated urinary tract infections, respiratory tract infections, biliary tract infections, abdominal infections, pelvic infections and Skin and soft tissue infections are widely used clinically. However, after years of use, many pathogenic bacteria have developed resistance to piperacillin. In order to solve the problem of drug resistance, people have developed a compound preparation of piperacillin, which uses β-lactamase inhibitors and piperacillin to formulate. The currently marketed ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/496A61K31/439A61P31/04
CPCA61K31/439A61K31/496A61K2300/00
Inventor 不公告发明人
Owner XIANGBEI WELMAN PHARMA CO LTD
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