Methods to enhance bioavailability of organic small molecules and deposited films made therefrom

Abstract

Solid films and articles having a surface with discrete regions patterned with a deposited low molecular weight organic compound, such as pharmaceutical actives and new chemical entities, are provided. The organic compound may be present at >= about 99 mass % in the one or more discrete regions and may be crystalline or amorphous. The deposited organic compound may be deposited as a film having high surface area. The deposited organic compound exhibits enhanced solubility and bioavailability, by way of non-limiting example. Methods of organic vapor jet printing deposition method of such a lowmolecular weight organic compound in an inert gas stream are also provided.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application No. 62 / 171,702, filed June 5, 2015. The entire disclosure of the above application is incorporated herein by reference. technical field [0003] The present disclosure relates to pure deposited films of low molecular weight organic compounds (eg, pharmaceutically active ingredients or new chemical entities), wherein such deposited low molecular weight organic compounds have enhanced bioavailability and solubility. Also provided are methods and apparatuses for depositing low molecular weight organic compounds by deposition methods, such as organic vapor jet printing deposition methods and apparatuses. Background technique [0004] This section provides background information related to the present disclosure which is not necessarily prior art. [0005] Solutions of small molecule organic compounds are widely used in many industries: food, cosmetics / perf...

AI Technical Summary

Problems solved by technology

However, nanosizing has many disadvantages

First, mechanical methods such as pulverization and high pressure homogenization (HPH) are energy and time consuming

Second, the resulting nanoparticles can lack storage stability and controlled release

Third, formulation with nanoparticles is challenging because homogeneity and stability are difficult to achieve due to particle agglomeration and changes in crystallinity

This method can be time and energy consuming and potentially damaging to the compound / solvent

[0010] Another disadvantage of submerging powdered solutes directly in a solvent is when the actual desired concentration or solution volume of the compound is very low

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