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Preparation method of calcium bis(2-hydroxy-4-(methylthio)butyrate)

A technology of calcium methylthiobutyrate and methylthiobutyric acid, which is applied in the fields of sulfide preparation and organic chemistry, can solve the problems of unstable feed quality, high calcium viscosity, complex process, etc., so as to improve production performance and The effects of immune performance, mild reaction conditions, and simple preparation process

Active Publication Date: 2018-04-06
BLUESTAR ADISSEO NANJING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The material produced by this method has high purity, but the process is more complicated due to the need for recrystallization and dehydration again
In actual production, these disclosed methods all have the problems of synthetic D, L-2-hydroxyl-4-methylthiobutyrate calcium, high viscosity, low density, poor fluency, etc., so it is difficult to fully mix with feed, and the quality of feed Unstable, thus affecting the feeding effect
[0020] In addition, the above-mentioned preparation method of calcium D,L-2-hydroxy-4-methylthiobutyrate generally has the following defects: once calcium oxide or calcium hydroxide reacts with 2-hydroxy-4-methylthiobutyrate , the reaction speed will be very fast, which will cause the pressure in the reaction vessel to increase rapidly and generate a large amount of heat, which will cause the reaction speed, pressure and temperature to be difficult to control, resulting in the coking of part of the product 2-hydroxy-4-methylthiobutyrate calcium , and wrap on the unreacted calcium oxide or calcium hydroxide to prevent its further reaction with 2-hydroxy-4-methylthiobutyric acid, thus affecting the yield and quality

Method used

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  • Preparation method of calcium bis(2-hydroxy-4-(methylthio)butyrate)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] At room temperature, under stirring with a stirrer (300-500r / min), first add 6.6g of ethanol to 20.0g of calcium oxide to make the calcium oxide completely wet, then quickly add the wet calcium oxide to 120.0g of D, L-2-hydroxy-4-methylthiobutyric acid was dried at 100°C for 24 hours to obtain the final product D, calcium L-2-hydroxy-4-methylthiobutyrate.

[0042] The above-mentioned D,L-2-hydroxy-4-methylthiobutyrate calcium has a yield of 98.09%, the reaction process is ideal, the product does not form a wall, and the product can be dispersed into In powder form, the whole process can be completed in a relatively short time; the reaction is rapid.

Embodiment 2

[0044] Same as Example 1, only the mass ratio of ethanol, calcium oxide and D, L-2-hydroxy-4-methylthiobutyric acid is modified as:

[0045] Group A: 1:2:12; the yield is 98.17%, the reaction is rapid, and the product becomes powder after the reaction.

[0046] Group B: 1:2.5:15; the yield rate is 97.86%, the reaction is rapid, and the product becomes powder after the reaction.

Embodiment 3

[0048] At room temperature, under agitator stirring (300-500r / min), first add 20.0g of water to 26.0g of calcium hydroxide to make the calcium hydroxide into a paste, then add the paste of calcium hydroxide to 120.0 g D,L-2-hydroxy-4-methylthiobutyric acid (feeding speed is about 50 seconds), and vacuum-dried at 100°C for 24h to obtain the final product D,L-2-hydroxy-4-methylthiobutyric acid Calcium acid.

[0049] The D,L-2-hydroxy-4-methylthiobutyrate calcium prepared above has a yield of 96.27%, and the reaction is relatively fast. As the reaction progresses, more and more heat is released, and the liquid becomes more and more viscous Until solidification, the resulting product is convenient for separation and subsequent processing.

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Abstract

The invention belongs to the technical field of preparation of feed additives and particularly relates to a preparation method of calcium bis(2-hydroxy-4-(methylthio)butyrate). The preparation methodcomprises the following steps: a calcium compound is uniformly mixed with a dispersant under stirring, the mixture is mixed with bis(2-hydroxy-4-(methylthio)butyrate) for a reaction, a product is dried, and the final product calcium bis(2-hydroxy-4-(methylthio)butyrate) is obtained. The method adopts a few process steps, reaction conditions are mild, the reaction is fast, and the total productioncost is low; the yield of prepared calcium bis(2-hydroxy-4-(methylthio)butyrate) is as high as 96% or higher, the product is loose and good in dispersity, and the problems of low yield and purity of calcium bis(2-hydroxy-4-(methylthio)butyrate), sticky and greasy filter cake, difficult suction filtration, poor smoothness and the like in actual production process are solved; According to the preparation method of calcium bis(2-hydroxy-4-(methylthio)butyrate), the formula is scientific and reasonable, the cost is low, and the preparation process is simple, fast and convenient and has quite greateconomic significance and social significance in industrial preparation of calcium bis(2-hydroxy-4-(methylthio)butyrate).

Description

technical field [0001] The invention belongs to the technical field of feed additive preparation, and in particular relates to a preparation method of calcium D,L-2-hydroxy-4-methylthiobutyrate. Background technique [0002] D,L-2-hydroxy-4-methylthiobutyric acid, also known as hydroxymethionine analog (MHA), is mainly used as a feed additive. As early as the 1950s, MHA has been applied in animal husbandry, and has been confirmed by the feed industry, animal husbandry and pet production enterprises that MHA is an excellent methionine source. Although MHA has many advantages, there are also 1) strong corrosive and pungent smell, inconvenient storage, transportation and use, and expensive special liquid feeding system must be used; It is not easy to mix evenly in the mixture; 3) A large amount of heat is released when it meets water, causing the feed to heat up and ferment and become rancid during storage and transportation; it is very acidic, with a pH of about 1, and it is ...

Claims

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Application Information

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IPC IPC(8): C07C323/52C07C319/20
CPCC07C319/20C07C323/52
Inventor 王农李开元
Owner BLUESTAR ADISSEO NANJING CO LTD
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