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A traditional Chinese medicine composition for treating refractory hypertension and its preparation method

A refractory and combination technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of incompletely clear pathogenesis, strong toxic and side effects of chemical drugs, etc.

Active Publication Date: 2020-11-17
THE CHINESE TRADITIONAL HERB MEDICINE RES INST HENAN PROV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] It can be seen from the above that hypertension is a complex pathological process involving multiple etiologies and multiple disease links under the influence of genetic and environmental factors. At present, its pathogenesis is not completely clear.
Refractory hypertension is a difficult point in the treatment of hypertension. Due to the diversity and uncertainty of its pathogenic factors, there is no effective specific treatment drug in Western medicine. Commonly used chemical drugs have strong toxic and side effects, and most of them damage the liver and kidney. Controlling symptoms at the expense of neither advisable nor solving the underlying problem

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A traditional Chinese medicine composition tablet for the treatment of refractory hypertension, comprising raw materials of the following weights: periwinkle 556g, Uncaria 556g, Achyranthes 556, Polyporus 556g, Prunella vulgaris 278g, Ligusticum chuanxiong 278g and White peony 278g.

[0022] The preparation method (1000 tablets) includes the following steps: weigh each raw material medicine by weight, mix, add 14 times the total weight of the raw material medicine and decoct 2 times for 1.5h each time, filter, combine the decoction and concentrate into A thick paste with a relative density of 1.10-1.12 at 50°C, add ethanol, stir while adding, until the ethanol concentration reaches 60% (v / v), let stand for 48h, filter, take the filtrate, recover the ethanol, and concentrate to 60°C For thick paste with relative density of 1.18-1.20, add 50 g of dextrin as auxiliary material and 150 g of powdered sugar as a base material, spray granulation, granulate, add 2% magnesium steara...

Embodiment 2

[0024] A traditional Chinese medicine composition powder for the treatment of refractory hypertension, comprising raw materials of the following weights: periwinkle 160g, Uncaria 160g, Achyranthes bidentata 150g, Polyporus umbellatus 150g, Prunella vulgaris 50g, Chuanxiong 50g, and White peony 50g.

[0025] The preparation method includes the following steps: mixing each raw material medicine, adding it to a high-speed multifunctional pulverizer, pulverizing, passing through a 200-mesh sieve to obtain ultra-fine Chinese medicine powder, distributing it into 1000 bags, sterilizing, and obtaining it.

Embodiment 3

[0027] A traditional Chinese medicine composition capsule for the treatment of refractory hypertension, comprising the following raw materials in weight: periwinkle 660 parts, Uncaria 660g, Achyranthes bidentata 600g, Polyporus umbellatus 600g, Prunella vulgaris 400g, Chuanxiong 400g, and White peony 330g.

[0028] The preparation method (1000 grains) includes the following steps: weigh vinca, Uncaria, Polyporus, Ligusticum chuanxiong and crush them by weight, add 8 times the weight and volume fraction of 70% ethanol and soak for 4 hours, and then reflux and extract 3 times at 80°C. After 1 hour, combine the water decoction and concentrate to a relative density of 1.10-1.12 at 50°C to obtain alcoholic extracts of Catharanthus roseus, Uncaria, Polyporus, and Ligusticum chuanxiong respectively; weigh Achyranthes Bidentata, Prunella vulgaris and White Peony , Mix, add 14 times the total weight of 3 kinds of raw materials and decoct 2 times, 1.5h each time, filter, combine the decocti...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating refractory hypertension and a preparation method thereof. The traditional Chinese medicine composition contains the following raw material drugs in parts by weight: 16-33 parts of catharanthus roseus, 16-33 parts of ramulus uncariae cum uncis, 15-30 parts of radix achyranthis bidentatae, 15-30 parts of polyporus, 5-30parts of spica prunellae, 5-30 parts of rhizoma chuanxiong and 5-16.5 parts of radix paeoniae alba. An inventor of the invention analyzes the depressurization properties, effective parts and synergistic effects of existing drugs by combining with pharmaceutical chemistry, adopts a theory and viewpoint of 'syndrome element integration' and innovatively utilizes a formula of catharanthus roseus, ramulus uncariae cum uncis, radix achyranthis bidentatae, polyporus, spica prunellae, rhizoma chuanxiong, radix paeoniae alba and the like, so that the traditional Chinese medicine composition is reasonable in compatibility, is fit with pathogenesis and capable of maintaining the stability of blood pressure and obviously improving the living quality of patients with refractory hypertension and has good social significance.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine composition for treating refractory hypertension and a preparation method thereof. Background technique [0002] Refractory hypertension (RH), also known as refractory hypertension, is a special type of hypertension with complex etiology. Uncontrolled hypertension can accelerate the progression of atherosclerosis, leading to heart, brain, and kidney Damage to other important target organs seriously affects the quality of life of patients and brings serious economic burdens to patients, families and society. According to my country's "Consensus of Chinese Experts on the Diagnosis and Treatment of Refractory Hypertension", RH is defined as the application of a reasonable and tolerable amount of ≥3 antihypertensive drugs (including diuretics) on the basis of improving lifestyle> Those whose blood pressure has not reached t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/74A61P9/12
CPCA61K36/07A61K36/21A61K36/236A61K36/24A61K36/536A61K36/65A61K36/71A61K36/74A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 刘明王慧森李更生高雅逯璐
Owner THE CHINESE TRADITIONAL HERB MEDICINE RES INST HENAN PROV