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Method for near-infrared detection of mass content of miscarriage-prevention pills

A technology of near-infrared detection and mass content, which is applied in measuring devices, material analysis through optical means, instruments, etc., can solve the problems that the active ingredients cannot be obtained quickly and accurately, and the quality of Antai pills is difficult to control.

Inactive Publication Date: 2018-04-17
GUANGZHOU ZHONGDA NANSHA TECH INNOVATION IND PARK +1
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Problems solved by technology

[0004] In order to solve the problem in the prior art that the quality of Antai Pills is difficult to control and its active ingredients cannot be quickly and accurately obtained, the present invention provides a method for detecting the mass content of Antai Pills by near-infrared, which can monitor the effective content of Antai Pills in real time. Changes in ingredients, and flexibly adjust the extraction scheme according to these conditions, so as to obtain high-quality Antai Pill extract

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  • Method for near-infrared detection of mass content of miscarriage-prevention pills
  • Method for near-infrared detection of mass content of miscarriage-prevention pills
  • Method for near-infrared detection of mass content of miscarriage-prevention pills

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Embodiment 1

[0029] Experimental instruments and reagents: Dionne high performance liquid chromatography ULtiMate 3000 (including gradient pump SR-3000, autosampler WPS-3000, column constant temperature system TCC-3000, ultraviolet detector DAD-3100, chromatography workstation Chameleon 7.2) ; XS205 DuaLRange type 1 / 100,000 analytical balance (Mettler-Toledo Instruments (Shanghai). Wahaha purified water (market purchase), acetonitrile (chromatographically pure, Merck, Germany), formic acid (analytical grade, Guangzhou Chemical Reagent Factory ).

[0030] Preparation of standard solution: Accurately weigh each standard in a volumetric flask, add appropriate amount of methanol to dissolve and prepare a mixed solution, which contains 0.00306mg / ml of ferulic acid, 0.10250mg / ml of baicalin, and 0.01840mg / ml of wogonin , 0.064mg / ml baicalein, 0.0378mg / ml wogonin, 0.00715mg / ml chrysanthemum lactone, 0.042mg / ml atractylodes lactone, shake well.

[0031] Preparation of the test solution: Take one ...

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Abstract

The invention discloses a method for near-infrared detection of the mass content of miscarriage-prevention pills. The method comprises the following steps of dissolving the miscarriage-prevention pills by using methanol, and filtering to obtain filtrate which is a test solution; carrying out near-infrared spectrum detection on the miscarriage-prevention pills and measuring the concentration of effective components in the corresponding test solution by high performance liquid chromatography; selecting a reasonable modeling near-infrared spectrum data area, and establishing a corresponding relation between the near-infrared spectrum data and the concentration of the effective components in the test solution; by utilizing the established corresponding relation, carrying out infrared spectrumdetection on the miscarriage-prevention pills to be detected to realize measurement for the concentration of the effective components in the miscarriage-prevention pills to be detected. Compared withthe HPLC (High Performance Liquid Chromatography), near-infrared spectroscopy is simpler and faster in operation, is suitable for content measurement of large-batch miscarriage-prevention pills, can meet the needs for large-scale sample information acquisition in industrial production and plays an important role in controlling the stability of a final preparation product.

Description

technical field [0001] The invention relates to a detection method for Antai Pills, in particular to a method for detecting the mass content of Antai Pills by near-infrared. Background technique [0002] Near-infrared spectroscopy analysis technology is widely called green analysis technology, which has the following unique advantages: fast analysis speed, high analysis efficiency, simple but environmentally friendly analysis process, no need for sample pretreatment or less treatment. Near-infrared spectroscopy is an indirect analysis method for qualitative or quantitative analysis of unknown samples by establishing a calibration model. The analysis process mainly includes: collecting samples, collection and preprocessing of near-infrared spectra, establishment and verification of calibration models, For predicting unknown samples, quantitative analysis also includes chemical analysis of sample standard values. [0003] In the field of traditional Chinese medicine quality c...

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Application Information

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IPC IPC(8): G01N21/359G01N21/3577
CPCG01N21/3577G01N21/359
Inventor 马晋芳王雪利葛发欢
Owner GUANGZHOU ZHONGDA NANSHA TECH INNOVATION IND PARK
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