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Graphene nano-silver lidocaine slow-release antibacterial gel

A technology of lidocaine and nano-silver, which is applied in the field of medical gel, can solve the problems of poor transdermal effect and limited action time, and achieve the effects of enhancing drug transdermal effect, enhancing antibacterial effect, and prolonging action time

Inactive Publication Date: 2018-04-20
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The object of the present invention is to provide graphene nano-silver lidocaine sustained-release antibacterial gel, which solves the problems of the non-nano sustained-release preparations of lidocaine gel commonly used at present, which have limited action time and poor transdermal effect. Nanosilver particles on ene supports enhance antibacterial activity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Step 1: Ultrasonic cracking of single-layer graphene oxide; take 2 g of single-layer graphene oxide in 1000 ml of deionized water for ice bath, and ultrasonic pulverizer for 1 hour to obtain 2 mg / ml of graphene oxide aqueous solution.

[0018] Step 2: Add silver nitrate and reducing agent to nano-graphene oxide to obtain nano-silver graphene oxide Ag-nGO; take 1g of graphene oxide aqueous solution and silver ammonia solution and stir at 50°C for 30 minutes, add 10g of glucose aqueous solution, and react at 95°C 1 hour. Obtain nano-silver graphene oxide Ag-Ngo. Silver ammonia solution is to adopt silver nitrate AgNO31.05g to dissolve in 50ml deionized water, add dropwise 3% ammonia solution until the precipitation disappears to obtain silver ammonia solution

[0019] Step 3: Mix nano-silver graphene oxide with lidocaine to obtain Ag-nGO-lido mixture; accurately weigh 3 g of base lidocaine and 1 g of nano-silver graphene oxide, add 100 ml of ethanol, stir at room tempera...

Embodiment 2

[0022] Step 1: Ultrasonic cracking of single-layer graphene oxide; take 2 g of single-layer graphene oxide in 1000 ml of deionized water for ice bath, and ultrasonic pulverizer for 1 hour to obtain 2 mg / ml of graphene oxide aqueous solution.

[0023] Step 2: Add silver nitrate and reducing agent to nano-graphene oxide to obtain nano-silver graphene oxide Ag-nGO; take 1g of graphene oxide aqueous solution and silver ammonia solution and stir at 50°C for 30 minutes, add 10g of glucose aqueous solution, and react at 95°C 1 hour. Obtain nano-silver graphene oxide Ag-Ngo. Silver ammonia solution is to adopt silver nitrate AgNO31.05g to dissolve in 50ml deionized water, add dropwise 3% ammonia solution until the precipitation disappears to obtain silver ammonia solution

[0024] Step 3: Mix nano-silver graphene oxide with lidocaine to obtain Ag-nGO-lido mixture; accurately weigh 3 g of base lidocaine and 1 g of nano-silver graphene oxide, add 100 ml of ethanol, stir at room tempera...

Embodiment 3

[0027] Step 1: Ultrasonic cracking of single-layer graphene oxide; take 2 g of single-layer graphene oxide in 1000 ml of deionized water for ice bath, and ultrasonic pulverizer for 1 hour to obtain 2 mg / ml of graphene oxide aqueous solution.

[0028] Step 2: Add silver nitrate and reducing agent to nano-graphene oxide to obtain nano-silver graphene oxide Ag-nGO; take 1g of graphene oxide aqueous solution and silver ammonia solution and stir at 50°C for 30 minutes, add 10g of glucose aqueous solution, and react at 95°C 1 hour. Obtain nano-silver graphene oxide Ag-Ngo. Silver ammonia solution is to adopt silver nitrate AgNO31.05g to dissolve in 50ml deionized water, add dropwise 3% ammonia solution until the precipitation disappears to obtain silver ammonia solution

[0029] Step 3: Mix nano-silver graphene oxide with lidocaine to obtain Ag-nGO-lido mixture; accurately weigh 3 g of base lidocaine and 1 g of nano-silver graphene oxide, add 100 ml of ethanol, stir at room tempera...

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PUM

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Abstract

The invention discloses graphene nano-silver lidocaine slow-release antibacterial gel. The preparation method comprises the following steps: performing supersonic decomposing on single-layer grapheneoxide in deionized water so as to obtain an aqueous solution of nano graphene oxide; adding silver nitrate and a reducing agent into the aqueous solution of nano graphene oxide so as to obtain nano-silver graphene oxide Ag-nGO; mixing the nano-silver graphene oxide and lidocaine to obtain an Ag-nGO-lido mixture; and dissolving Carbomer 940, PEG400 and glycerin into deionized water, enabling the Carbomer 940 to be fully dispersed at a normal temperature, dissolving the Ag-nGO-lido into the dispersed solution after dispersing, adding sodium hydroxide and potassium sorbate to be dissolved, supplementing deionized water, and fully mixing, thereby obtaining the product. The graphene nano-silver lidocaine slow-release antibacterial gel disclosed by the invention has the beneficial effects that the lidocaine is adsorbed onto the surface of a nano-carrier, is slowly released and has effects of obviously prolonging action time of the lidocaine and enhancing transdermal effects of drugs; a graphene composite nano-silver material serves as a carrier, the graphene and silver ions have antibacterial effects, particularly the silver ions have excellent antibacterial abilities and do not have drug tolerance, and risk of infection caused by long-term retention catheterization can be reduced.

Description

technical field [0001] The invention belongs to the technical field of medical gels, and relates to a graphene nano-silver lidocaine sustained-release antibacterial gel. Background technique [0002] Currently commonly used lidocaine gel non-nanometer sustained-release preparations have limited action time. Commonly used lidocaine gel produces anesthesia through the permeation transdermal of the drug itself or adds a transdermal agent in the preparation, and the transdermal effect is not good. Currently commonly used lidocaine gel has a certain antibacterial effect, but its antibacterial ability is limited. It has no antibacterial effect on some special bacteria, such as Pseudomonas aeruginosa, and it may cause infection when indwelling the catheter for a long time. Contents of the invention [0003] The object of the present invention is to provide graphene nano-silver lidocaine sustained-release antibacterial gel, which solves the problems of the non-nano sustained-rele...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/44A61K47/04A61K9/06A61P31/04A61P23/02A61K31/167A61K33/38
CPCA61K9/0014A61K9/06A61K31/167A61K33/38A61K33/44A61K47/02A61K2300/00
Inventor 滕士勇杨文胜郭子龙宋雪松麻海春李志文
Owner JILIN UNIV
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