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Method for separating and purifying quercetin in common seepweed herb by use of supercritical simulated moving bed chromatographic system

A technology for simulating moving bed and chromatographic systems, applied in organic chemistry, bulk chemical production, etc., can solve the problems of expensive supercritical fluid chromatography equipment, unsatisfactory purification effect, low purity, etc., to achieve continuous automatic operation, excellent Mass transfer performance, high purity effect

Inactive Publication Date: 2018-04-20
BOHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Column chromatography mainly uses the principle of separation and purification based on the different adsorption capacities of different components of the fixed phase. The purification effect of this purification method is not ideal, and there are disadvantages such as low purity and poor efficiency.
High-performance liquid chromatography consumes a large amount of solvent products are too diluted and often cannot avoid the use of toxic solvents; supercritical fluid chromatography technology equipment is quite expensive, and the application of this technology in the laboratory is far greater than its application in industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 1.1 Screening of Suaeda salsa

[0035] Choose Suaeda salsa with moderate size, fresh color and no pests;

[0036] 1.2 Pretreatment of Suaeda salsa

[0037] (1) Cleaning treatment

[0038] Soak the Suaeda salsa in clean water and rinse until there is no dirt on the Suaeda salsa;

[0039] (2) Drying treatment

[0040] Spread the Suaeda salsa flat and place it in a well-ventilated environment for drying treatment, and dry it in an oven at 60°C for 2 hours; make the moisture on the surface of Suaeda salsa dry;

[0041] (3) Finished

[0042] Carry out greening under microwave, spread the Suaeda salsa leaf thickness 3 centimeters, 2kw microwave treatment 15 minutes;

[0043] (4) Smash

[0044] The dried Suaeda salsa is pulverized in a pulverizer at room temperature, and passed through a 60-mesh sieve;

[0045] 1.3 Extraction of quercetin

[0046] Suaeda quercetin was extracted by ultrasonic-assisted hydroenzyme method, treated with compound enzyme: cellulase: pectinas...

Embodiment 2

[0053] 1.1 Screening of Suaeda salsa

[0054] Choose Suaeda salsa with moderate size, fresh color and no pests;

[0055] 1.2 Pretreatment of Suaeda salsa

[0056] (1) Cleaning treatment

[0057] Soak the Suaeda salsa in clean water and rinse until there is no dirt on the Suaeda salsa;

[0058] (2) Drying treatment

[0059] Spread the Suaeda salsa flat and place it in a well-ventilated environment for drying treatment, and dry it in an oven at 60°C for 2 hours; make the moisture on the surface of Suaeda salsa dry;

[0060] (3) Finished

[0061] Carry out greening under microwave, spread the Suaeda salsa leaf thickness 3 centimeters, 2kw microwave treatment 15 minutes;

[0062] (4) Smash

[0063] The dried Suaeda salsa is pulverized in a pulverizer at room temperature, and passed through a 60-mesh sieve;

[0064] 1.3 Extraction of quercetin

[0065] Suaeda quercetin was extracted by ultrasonic-assisted hydroenzyme method, treated with compound enzyme: cellulase: pectinas...

Embodiment 3

[0072] 1.1 Screening of Suaeda salsa

[0073] Choose Suaeda salsa with moderate size, fresh color and no pests;

[0074] 1.2 Pretreatment of Suaeda salsa

[0075] (1) Cleaning treatment

[0076] Soak the Suaeda salsa in clean water and rinse until there is no dirt on the Suaeda salsa;

[0077] (2) Drying treatment

[0078] Spread the Suaeda salsa flat and place it in a well-ventilated environment for drying treatment, and dry it in an oven at 60°C for 2 hours; make the moisture on the surface of Suaeda salsa dry;

[0079] (3) Finished

[0080] Carry out greening under microwave, spread the Suaeda salsa leaf thickness 3 centimeters, 2kw microwave treatment 15 minutes;

[0081] (4) Smash

[0082] The dried Suaeda salsa is pulverized in a pulverizer at room temperature, and passed through a 60-mesh sieve;

[0083] 1.3 Extraction of quercetin

[0084] Suaeda quercetin was extracted by ultrasonic-assisted hydroenzyme method, treated with compound enzyme: cellulase: pectinas...

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Abstract

The invention relates to a method for separating and purifying quercetin in common seepweed herb, in particular to a method for separating and purifying quercetin in common seepweed herb by use of a supercritical simulated moving bed chromatographic system. The whole process of extracting, separating and purifying quercetin from common seepweed herb adopts water or ethyl alcohol which is friendlyto equipment and the environment as a solvent, the solvent is convenient to recover, and the energy consumption is low. As flavonoid constituents are unstable, have high probability of being oxidized,and have probability of being oxidized particularly in a high-temperature environment. The adopted extraction method can be finished at the room temperature; the extraction temperature is controllednot to exceed 70 DEG C; and the condition is mild; not only is the flavonoid constituent extraction effect not influenced, but also stable existence of the flavonoid constituents is facilitated. By adoption of the method, the continuity is enhanced, the purity of gallic acid is high, the production cycle is shortened, and the cost is low.

Description

【Technical field】 [0001] The invention belongs to the field of separation and purification of quercetin in Suaeda salsa, and particularly relates to a method for separating and preparing quercetin in Suaeda salsa by using an emerging supercritical simulated moving bed chromatography system. 【Background technique】 [0002] Quercetin, chemical name 3,5,7,3′,4′-pentahydroxyflavone, also known as quercetin, quercetin, is the most widely distributed flavonoids in the plant kingdom, distributed in about 68 In % of plants, it often exists in the flowers, leaves and fruits of plants. As a representative type of flavonoids, it has the functions of expectorant, cough and asthma. In addition, it has the effects of lowering blood pressure, lowering blood fat, anti-tumor, relaxing blood vessels, enhancing capillary resistance, reducing capillary fragility, lowering blood fat, expanding coronary arteries, and increasing coronary blood flow. It can be used to treat chronic bronchitis, It...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/30C07D311/40
CPCC07D311/30C07D311/40Y02P20/54
Inventor 朱丹实张红运李君刘贺李泓胜杨立娜郝春光赵宏伟李晓娟
Owner BOHAI UNIV
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