Applications of arctiin and arctigenin in preparation of anti-pulmonary fibrosis drugs

A technique for arctigenin and pulmonary fibrosis, which is applied in the field of natural medicinal chemistry, can solve the problems of unreported effects of arctiside and arctigenin on pulmonary fibrosis and the like, achieves wide application value, clear pharmacological activity, and improves pulmonary fibrosis. the effect of

Inactive Publication Date: 2018-05-01
CHENGDU BIOPURIFY LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the effect of arctiin and arctigenin on improving pulmonary fibrosis and its use in drugs for the treatment of this disease

Method used

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  • Applications of arctiin and arctigenin in preparation of anti-pulmonary fibrosis drugs
  • Applications of arctiin and arctigenin in preparation of anti-pulmonary fibrosis drugs
  • Applications of arctiin and arctigenin in preparation of anti-pulmonary fibrosis drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 Arctiin and arctigenin improve bleomycin-induced pulmonary fibrosis in mice

[0022] 1 Materials and instruments

[0023] Clean grade C57BL / 6 mice, male, weighing 18-22 g, were provided by Yangzhou Comparative Medicine Center. Wahaha purified water. Prednisone acetate was purchased from Zhejiang Xianju Pharmaceutical Co., Ltd. Chloral hydrate, Sinopharm Chemical Reagent Co., Ltd. Hydroxyproline kit, Nanjing Jiancheng Institute of Bioengineering.

[0024] experimental method

[0025] Clean-grade C57BL / 6 male mice were divided into blank group, model group, positive drug group, low-dose mangosteen extract group, and high-dose mangosteen extract group, with 10 mice in each group. Mice were anesthetized by intraperitoneal injection of 10ml / kg and 4% chloral hydrate. After the mice were anesthetized, the mice were fixed and the necks of the mice were disinfected. Cut the mouse neck skin longitudinally with scissors, and bluntly tear the fascia and muscles lon...

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Abstract

The present invention provides new medical uses of arctiin and arctigenin, particularly medical uses of arctiin and arctigenin in treatment or / and prevention of pulmonary fibrosis. The present invention further provides a pharmaceutical composition using arctiin or / and arctigenin as active components and used for treating or / and preventing pulmonary fibrosis. According to the present invention, the experiment results prove that arctiin and arctigenin can effectively improve the symptoms of pulmonary fibrosis in experimental animals, can provide anti-pulmonary fibrosis effect, and are potentialpulmonary fibrosis treatment drugs; and arctiin and arctigenin are derived from natural plants, and have advantages of wide original plant distribution, rich resources, low industrial preparation cost and easy popularization and application.

Description

technical field [0001] The invention belongs to the field of natural medicinal chemistry, and specifically relates to the new medical application of two traditional Chinese medicine monomers arctiin and arctigenin in preventing or / and treating pulmonary fibrosis. Background technique [0002] Pulmonary fibrosis (PF) is a lung disease mainly manifested by diffuse interstitial changes in the lungs. Its pathological changes mainly start from the infiltration of inflammatory cells in the lower respiratory tract, and gradually cause damage to alveolar epithelial cells and vascular endothelial cells. , accompanied by myofibroblast (myofibroblast, MF) and type II alveolar epithelial cell proliferation, resulting in excessive deposition of extracellular matrix (extracellular matrix, ECM) and collagen, and eventually fibrosis. Many factors can cause pulmonary fibrosis, such as radiation injury, occupational dust (SiO 2 etc.) and certain drugs (bleomycin), etc. At present, the main ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/365A61P11/00
CPCA61K31/7048A61K31/365A61K2300/00
Inventor 张朝凤潘华罗明锋谢海峰胡云岭谢期林郭建龙
Owner CHENGDU BIOPURIFY LTD
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