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Pregabalin oral solution and preparation method thereof

A technology of pregabalin and oral solution, which is applied in the field of pharmaceutical preparations and can solve problems such as weak affinity

Inactive Publication Date: 2018-05-08
GUANGZHOU DAGUANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although pregabalin is structurally similar to γ-aminobutyric acid (GABA), it has weaker affinity for GABAA and GABAB receptors

Method used

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  • Pregabalin oral solution and preparation method thereof
  • Pregabalin oral solution and preparation method thereof
  • Pregabalin oral solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] prescription:

[0015] Pregabalin 20g

[0016] Sodium dihydrogen phosphate 25.8g

[0017] Disodium hydrogen phosphate 0.4g

[0018] Methylparaben 0.13g

[0019] Propylparaben 0.0163g

[0020] Sucralose 5g

[0021] Strawberry essence 2g

[0022] Add water to 1000ml

[0023] Add 5g of sucralose, 0.13g of methylparaben, and 0.0163g of propylparaben to the configuration container, add an appropriate amount of purified water to dissolve, then add 25.8g of sodium dihydrogen phosphate, 0.4g of disodium hydrogen phosphate, and add pregabalin 20g and strawberry essence 2g, add purified water to the full amount, measure the pH value, the range is between pH5.0-7.0.

Embodiment 2

[0025] prescription:

[0026] Pregabalin 20g

[0027] Sodium dihydrogen phosphate 25.8g

[0028] Disodium hydrogen phosphate 0.4g

[0029] Methylparaben 0.13g

[0030] Propylparaben 0.0163g

[0031] Acesulfame K 5g

[0032] Strawberry essence 1g

[0033] Add water to 1000ml

[0034] Add 5g of acesulfame potassium, 0.13g of methylparaben, and 0.0163g of propylparaben to the configuration container, add an appropriate amount of purified water to dissolve, then add 25.8g of sodium dihydrogen phosphate, 0.4g of disodium hydrogen phosphate, and add pregabalin 20g and 1g of strawberry essence, add purified water to the full amount, measure the pH value, the range is between pH5.0-7.0.

Embodiment 3

[0036] prescription:

[0037] Pregabalin 20g

[0038] Sodium dihydrogen phosphate 25.8g

[0039] Disodium hydrogen phosphate 0.4g

[0040] Methylparaben 0.13g

[0041] Propylparaben 0.0163g

[0042] Sorbitol 40g

[0043] Strawberry essence 2g

[0044] Add water to 1000ml

[0045] Add 40g of sorbitol, 0.13g of methylparaben, and 0.0163g of propylparaben to the configuration container, add an appropriate amount of purified water to dissolve, then add 25.8g of sodium dihydrogen phosphate, 0.4g of disodium hydrogen phosphate, and 20g of pregabalin And strawberry essence 2g, add purified water to the full amount, measure the pH value, the range is between pH5.0-7.0.

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PUM

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Abstract

The invention relates to a pregabalin oral solution and a preparation method thereof. The oral liquid preparation is prepared from pregabalin, preservative, a buffering agent, corrigent and other component. Water is adopted as a solvent, by means of quantitative matching and synergy of all the components, the oral liquid preparation has good stability, the taste is well improved, the life qualityand the drug use compliance of patients are also effectively improved, the bioavailability of the oral liquid preparation is obviously higher than that of solid preparations, and the oral solution ismore suitable for being drunk by old people or children.

Description

technical field [0001] The invention relates to an oral liquid preparation containing pregabalin, which belongs to the field of pharmaceutical preparations. Background technique [0002] Neuropathic pain refers to the pain caused by damage or lesions of the nervous system, which is mainly characterized by dull pain, burning, and tingling pain. Epilepsy, one of the common diseases of the nervous system, is a chronic, recurrent short-term brain dysfunction syndrome. Epilepsy is an important public health problem no matter in developed or developing countries. Herpes zoster is a disease of acute skin and mucous membrane infection, which is caused by the varicella-zoster virus, which leads to clusters of skin blisters and easy ulceration and infection. Postherpetic neuralgia is the most serious complication of herpes zoster. Accompanied by tearing and needle-like pain during the attack, the patient has trouble sleeping and eating, and is often accompanied by symptoms of depress...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/197A61K47/02A61K47/14A61K47/26A61K47/22A61P25/02A61P25/00A61P25/08A61P25/22A61P29/00A61P21/00
CPCA61K9/0095A61K31/197A61K47/02A61K47/14A61K47/22A61K47/26
Inventor 陈伟翰黄伟静李佳佳
Owner GUANGZHOU DAGUANG PHARMA
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