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Preparation method of algal polysaccharide sulfate capsule

A fucoidan and sulfate technology, applied in the field of biomedicine, can solve the problems of decreased bioavailability, decreased dissolution, unable to meet the dissolution requirements of capsules, etc., achieves good fluidity, improves quality, and ensures process preparation and quality. desired effect

Inactive Publication Date: 2018-05-11
INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the capsule preparation process, the applicant found that conventional gelatin hollow capsules were used to prepare fucoidan sulfate capsules. Fucoidan sulfate easily combined with gelatin to form co-precipitation under acidic and alkaline conditions, resulting in a decrease in dissolution rate and bioavailability. , can not meet the capsule dissolution requirements

Method used

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  • Preparation method of algal polysaccharide sulfate capsule
  • Preparation method of algal polysaccharide sulfate capsule
  • Preparation method of algal polysaccharide sulfate capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] The prescription composition of a kind of capsule for the treatment of diabetic foot ulcer of the present invention:

[0055]Prescription: (1000) capsules

[0056]

[0057] Pack into 1000 No. 1 seaweed polysaccharide hollow capsules

[0058] The preparation method is as follows: respectively passing low-molecular weight fucoidan, a filler and a lubricant through an 80-mesh sieve for standby use.

[0059] Weigh the filler and lubricant auxiliary materials according to the prescription quantity, mix them evenly, pass through an 80-mesh sieve, add low molecular weight fucoidan sulfate as the raw material of the prescription quantity, and mix well; measure the angle of repose, ≤30°; measure the content of the powder raw materials, and determine the loading capacity; Fill with No. 1 seaweed polysaccharide hollow capsule. The low molecular weight fucoidan sulfate capsules were obtained.

[0060] It should be noted that the above descriptions are only preferred embodimen...

Embodiment 2

[0074] The prescription composition of a kind of fucoidan sulfate capsules of preventing diabetic foot vascular disease of the present invention:

[0075] Prescription: (1000) capsules

[0076]

[0077] Pack into 1000 No. 1 seaweed polysaccharide hollow capsules

[0078] The preparation method is as follows: separately pass the fucoidan, filler and lubricant through 80-mesh sieve for standby.

[0079] Weigh the filler and lubricant auxiliary materials according to the prescription quantity, mix them evenly, pass through an 80 mesh sieve, add the raw material fucoidan sulfate in the prescription quantity, and mix well; measure the angle of repose, ≤30°; measure the content of the powder raw materials, and determine the loading capacity; use 1 No. seaweed polysaccharide hollow capsule filling. That is, fucoidan sulfate capsules were obtained.

[0080] Stability test of influencing factors

[0081] In order to investigate the rationality of the prescription design of this ...

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Abstract

The invention relates to an algal polysaccharide sulfate capsule, a formula of the algal polysaccharide sulfate capsule with low molecular weight, and a preparation process thereof. The formula meetsthe clinic requirement and the capsule is convenient to take by patients. The formula of the algal polysaccharide sulfate capsule provided by the invention is prepared from algal polysaccharide sulfate or algal polysaccharide sulfate with low molecular weight and pharmaceutically acceptable ingredients. Empty capsules are algal polysaccharide capsules and other types of polysaccharide capsules unreacted with a main drug; the acceptable ingredients comprise a filling agent, a lubricating agent and the like; through screening different types of empty capsules and relevant ingredients, the capsule with good dissolubility, good stability, and unreaction with the main drug and the ingredients is obtained. The invention also provides the preparation process of the algal polysaccharide sulfate capsule or the algal polysaccharide sulfate capsule with low molecular weight. The preparation method comprises the steps of uniformly mixing the ingredients of the formula, sieving through a 80-mesh sieve, adding the main drug into the sieved ingredients, uniformly mixing, inspecting an intermediate, filling the capsule, packaging, and obtaining a finished product.

Description

technical field [0001] The invention relates to a prescription of fucoidan sulfate capsules and a preparation process thereof, belonging to the technical field of biomedicine. Background technique [0002] Fucoidan is a kind of sulfated polysaccharide, which exists in brown algae. It was first extracted from palmate kelp by Kylin in 1913 with dilute acid. According to the naming principle of polysaccharides, it is generally named fucoidan, and the Chinese name is ink. Carrageenan, fucoidan, fucoidan, fucoidan sulfate, fucoidan or fucoidan sulfate. Now people have a relatively clear understanding of the composition of fucoidan sulfate esters. It is a type of polysaccharide with very complex chemical composition and structure. It is mainly composed of fucose and sulfate groups. Sugar, uronic acid and other ingredients. Low-molecular-weight fucoidan sulfate with a molecular weight of 1000-20000 Da can be prepared by degrading fucoidan sulfate in a suitable way. Fucoidan sulf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/737A61K47/36A61K47/38A61K47/04A61K47/12A61P3/10A61P9/00
Inventor 张全斌谭姣姣王晶岳洋张虹牛锡珍
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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