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Bio-fermentation method for preparing 1,3-propanediol

A technology of biological fermentation and propylene glycol, applied in microorganism-based methods, biochemical equipment and methods, fermentation and other directions, can solve the problems of low concentration, high cost, low fermentation level, etc., and achieve the effect of reducing production costs

Inactive Publication Date: 2018-05-25
HUNAN ER KANG PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In the above methods 1 and 2 use glycerol as the substrate for fermentation, and the concentration of 1,3-propanediol in the fermentation broth is relatively low, so the cost is very high
Method 3 proposes simultaneous fermentation to produce 1,3-propanediol and 2,3-butanediol, but the process limits fermentation to low levels

Method used

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  • Bio-fermentation method for preparing 1,3-propanediol
  • Bio-fermentation method for preparing 1,3-propanediol

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Set A, B, C, D implementation groups

[0025] 1. Liquefaction and saccharification of crude starch

[0026] Add 500g of starch, add water to make starch milk with a mass fraction of 36%, add 0.6 g of high temperature resistant α-amylase (5U / g) and the DE value of the liquefaction solution is 18%. The liquefied solution was introduced into the mash tun, and 5 g of glucoamylase (200 U / g) was added, and the glucose value measured at the end of saccharification was 98%.

[0027] 2. Fermentation of saccharification liquid to produce glycerin

[0028] Prepare the feed solution (g / L): urea 2.5, glucose concentration 315, corn steep liquor 3 with a phosphorus content of 80 μg / mL, astragalus extract 10 (groups A and C do not add astragalus extract, groups B and D add). Introduce the 50L culture medium after continuous elimination and the expanded strains into the No. 1 fermenter that has been strictly sterilized. Introduce sterile air for aerobic fermentation. The temperatur...

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Abstract

The invention discloses a bio-fermentation method for preparing 1,3-propanediol. The method comprises the following steps: performing aerobic and anaerobic fermentation on crude starch as a raw material in a No. 1 fermentation tank by adopting pressure-resistant yeast to obtain glycerol fermentation broth, filtering the fermentation broth, recovering thalli for next fermentation, transferring a filtrate into a No. 2 fermentation tank accommodating Klebsiella pneumoniae for anaerobic fermentation, performing flocculating, filtering, evaporating and concentrating, reduced pressure distillation and decolorization on the fermentation broth to obtain the finished product 1,3-propanediol. With application of the method, the technical level of bio-fermentation in China is greatly improved, raw materials can be used to the greatest extent, the production cost is effectively reduced, productivity of 1,3-propanediol is improved, and the method is more suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of biochemical technology, and in particular provides a method for producing 1,3-propanediol from crude starch. Background technique [0002] 1,3-Propanediol is a colorless transparent viscous liquid and is an important chemical raw material. It can be directly used in antifreeze, and can also be a synthetic raw material for plasticizers, detergents, preservatives and emulsifiers , Widely used in food, cosmetics and pharmaceutical industries. 1,3-Propanediol is an organic compound with bifunctional groups, which can be used as a monomer to produce polymers such as polyester, polyether, and polyurethane, and has a huge market potential. In particular, polyester (PTT) synthesized from 1,3-propanediol and terephthalic acid is an excellent polyester material with many excellent properties, such as good elasticity, stain resistance, colorability and Antistatic and biodegradability, etc., very suitable as fiber and textil...

Claims

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Application Information

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IPC IPC(8): C12P7/18C12P19/14C12R1/22
CPCC12P7/18C12P19/14
Inventor 帅放文王向峰章家伟
Owner HUNAN ER KANG PHARMA
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