Sodium fructose diphosphate capsule and preparation method thereof

A technology of sodium fructose diphosphate and capsules, applied in the field of biomedicine, can solve the problems of uneven mixing, low stability and low recovery rate, and achieve the effects of uniform product content, easy preservation and high production efficiency

Active Publication Date: 2019-06-11
HAINAN JINXING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of this, the present invention provides a sodium fructose diphosphate capsule, which solves the problems of low curative effect, uneven mixing, low stability and low recovery rate

Method used

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  • Sodium fructose diphosphate capsule and preparation method thereof
  • Sodium fructose diphosphate capsule and preparation method thereof
  • Sodium fructose diphosphate capsule and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0025] A sodium fructose diphosphate capsule, comprising the following components by weight: 100 g of sodium fructose diphosphate, 1 g of gel-process silicon dioxide, the average particle diameter of said sodium fructose diphosphate is 300 μm, and the average particle diameter of said silicon dioxide is 2 μm.

[0026] The preparation method of described sodium fructose diphosphate capsule, comprises the following steps:

[0027] (1) Material preparation: Weigh 100 g of sodium fructose diphosphate for use, and 1 g of gel-method silicon dioxide for use.

[0028] (2) Mixing: Sodium fructose diphosphate is moistened with water, and the weight ratio of sodium fructose diphosphate and water is 10:1, and gel method silicon dioxide is added to mix in a mixer. The mixing frequency of the mixer is 15Hz, a mixture was obtained.

[0029] (3) Granulation: The mixture is made into wet granules in a wet granulator filled with alcohol air flow, passed through a 20-mesh sieve, and then put i...

Embodiment 2

[0035] A sodium fructose diphosphate capsule, comprising the following components by weight: 300 g of sodium fructose diphosphate, 5 g of gel-process silicon dioxide, the average particle diameter of said sodium fructose diphosphate is 600 μm, and the average particle diameter of said silicon dioxide is 600 μm. is 14 μm.

[0036] The preparation method of described sodium fructose diphosphate capsule, comprises the following steps:

[0037] (1) Material preparation: 300 g of sieved sodium fructose diphosphate was weighed for use, and 5 g of sieved gel method silica was taken for use.

[0038] (2) Mixing: Sodium fructose diphosphate is moistened with water, the weight ratio of sodium fructose diphosphate and water is 10:5, and gel method silica is added to mix in a mixer. The mixing frequency of the mixer is 35Hz, the mixture was obtained.

[0039] (3) Granulation: make the mixture into wet granules in a wet granulator filled with alcohol air flow, pass through a 30-mesh siev...

Embodiment 3

[0045] A sodium fructose diphosphate capsule, comprising the following components in parts by weight: 150 g of sodium fructose diphosphate, 2 g of gel-formed silicon dioxide, the average particle diameter of the sodium fructose diphosphate is 400 μm, and the average particle size of the silicon dioxide is 400 μm. The diameter is 5 μm.

[0046] The preparation method of described sodium fructose diphosphate capsule, comprises the following steps:

[0047] (1) Raw material preparation: 150 g of sieved sodium fructose diphosphate was weighed for use, and 2 g of sieved gel method silica was taken for use.

[0048] (2) Mixing: Sodium fructose diphosphate is moistened with water, the weight ratio of sodium fructose diphosphate and water is 10:2, and gel method silica is added to mix in a mixer. The mixing frequency of the mixer is 20Hz, the mixture was obtained.

[0049] (3) Granulation: Make the mixture into wet granules in a wet granulator filled with alcohol airflow, pass throu...

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Abstract

The invention discloses a fructose sodium diphosphate capsule and a preparation method thereof. The fructose sodium diphosphate capsule is prepared from the following components in parts by weight: 100-300 parts of fructose sodium diphosphate and 1-5 parts of gel method silicon dioxide, the average particle size of the fructose diphosphate is 300-600 microns, and the average particle size of the silicon dioxide is 2-14 microns. The capsule disclosed by the invention has the advantages that the capsule can maximally preserve the pesticide effect of the medicine in use, the stability is improved, and the content is uniform, and the like.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a sodium fructose diphosphate capsule and a preparation method thereof. Background technique [0002] Sodium fructose diphosphate is an important product of cell products. It can regulate the efficacy of several enzyme activities in glucose metabolism. It is a molecular level drug that restores and improves cell metabolism. It has clinical adjuvant treatment for coronary heart disease, arrhythmia, and acute cerebral infarction. , neonatal hypoxic-ischemic encephalopathy and other diseases. [0003] In the preparation of capsules, firstly fill the empty capsules with drugs, and also fill a variety of coated particles that release drug effects at different times to meet the needs of long-acting comprehensive treatment. Finally, sealing is a very important process. After the material is filled, it is sealed to prevent the contents in the shell from being exposed and causing pol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/04A61K31/7024A61P9/10A61P9/06
CPCA61K9/1611A61K31/7024
Inventor 张丽杰刘全胜
Owner HAINAN JINXING PHARMA
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