Method for preparing cyromazine

Abstract

The invention discloses a method for preparing cyromazine. The method includes steps of 1), dissolving cyanuric chloride in organic solvents under stirring conditions at the temperature of 0-5 DEG C,then dropwise adding industrial ammonia water into the organic solvents to obtain mixtures, heating the mixtures until the temperatures of the mixtures reach 40-45 DEG C, carrying out thermal reactionfor 5-6.5 h to obtain reaction liquid, separating solvents from the reaction liquid, adding purified water into residual liquid, stirring the purified water and the residual liquid for 1-1.5 h to obtain mixed liquid, cooling the mixed liquid until the temperature of the mixed liquid reaches the room temperature and carrying out suction filtration, washing and drying to obtain an intermediate which is 2-chlorine-4.6-diamino-1.3.5-triazine; 2), adding the intermediate prepared at the step 1) into purified water at the room temperature, adding cyclopropylamine into the purified water to obtain first mixtures, heating the first mixtures until the temperatures of the first mixtures reach 90-95 DEG C, dropwise adding acid binding agents into the first mixtures to obtain second mixtures, regulating the pH (potential of hydrogen) of the second mixtures until the pH of the second mixtures reaches 7.5-8.5, then carrying out reaction at the temperature of 98-100 DEG C for 3.5-4.5 h, carrying outdecolorization and filter to obtain reaction solution, cooling the reaction solution until the temperature of the reaction solution reaches 40-50 DEG C, crystallizing the reaction solution for 1-2 h,continuing to cool crystals until the temperatures of the crystals range from -5 DEG C to 0 DEG C, carrying out suction filtration and washing and then carrying out drying to obtain the cyromazine. The method has the advantages that the method includes simple processes and is high in safety and low in cost, and industrial production can be facilitated; the cyromazine which is a product is high inpurity, low in impurity content and good in stability.

Description

technical field [0001] The invention belongs to the technical field of pesticides and veterinary drugs, and in particular relates to a preparation method of cyromazine. Background technique [0002] Cyromazine (Cyromazine) is a triazine compound, the chemical name is 2-cyclopropylamino-4,6-diamino-1,3,5-triazine (N-Cyclopropyl-1,3,5- triazine-2,4,6-triamine), which has the characteristics of insect growth regulation and insecticidal specificity, can be degraded by microorganisms, has no residual toxicity, is safe to use, and does not pollute the environment. It is a new type of high-efficiency, low-toxic, nitrogen-containing heterocycle Insecticides, also known as cyromazine because it also has a fly-killing effect. [0003] At present, the method for preparing cyromazine mainly contains following several kinds: [0004] 1) With cyanuric chloride, cyclopropylamine, industrial ammonia (20%) and liquid ammonia as raw materials, three-step synthesis of cyromazine, the synthet...

AI Technical Summary

Problems solved by technology

The disadvantage of this method is that the use of acetone and ethanol in industrial production has a high risk factor, especially acetone, which is flammable and explosive, which brings great safety hazards to industrial production.

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