Method for extracting polysaccharides for treating senile hyperlipidemia from black fungus

A black fungus, age-related technology, applied in the direction of medical formula, organic active ingredients, medical preparations containing active ingredients, etc., can solve the problems of easily damaged polysaccharide structure, lower bioavailability, low extraction rate, etc., and achieve lipid-lowering Good curative effect, sufficient release and high extraction rate

Inactive Publication Date: 2018-05-29
AFFILIATED YONGCHUAN HOSPITAL OF CHONGQING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the extraction methods of fungus polysaccharide mainly include hot water extraction method, high temperature and high pressure method, acid extraction method, alkali extraction method, microwave extraction method, ultrasonic extraction method, etc., and the extraction rate is about from 0.8% to 28%. Among these extraction methods, the hot water extraction method and the high temperature and high pressure method mainly use cell expansion to change the osmotic pressure inside and outside the cell wall, and dissolve the fungus polysaccharide from it. However, because of the existence of the cell wall, it is generally difficult for the fungus polysaccharide to diffuse out of the cell. The extraction rate of water extraction is only about 15%. Although the extraction rate can reach about 28% by high temperature and high pressure extraction method, high temperature and high pressure can easily make the fungus polysaccharide denature and lose its activity; acid extraction and alkali extraction can easily destroy the polysaccharide. The structure has the disadvantage of reducing its bioavailability; the general extraction rate of ultrasonic extraction wave and microwave extraction method is about 11%.

Method used

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  • Method for extracting polysaccharides for treating senile hyperlipidemia from black fungus
  • Method for extracting polysaccharides for treating senile hyperlipidemia from black fungus

Examples

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Embodiment 1

[0035] A method for extracting and treating senile hyperlipidemia from black fungus, comprising the following steps,

[0036] A1. Take 1 kg of dried black fungus, crush the black fungus into fine particles with a particle size of 200-300 mesh, and then soak it in 10L warm water at a temperature of 40°C for 5 hours;

[0037] A2. Put the soaked black fungus and water together in the first container and seal it. The volume of the first container is 25L, heat treatment for 30min, and use microwave heating. The frequency of the microwave is controlled at 1200-3000MHz, and the microwave power is 850W. The time is 12 minutes, the center wavelength is 93-142mm, so that the temperature in the first container reaches 50-60°C;

[0038] A3. Prepare the second container, the volume of the second container is 60L, vacuumize the second container, connect the pipeline between the first container and the second container, set the switching valve on the pipeline, and connect the first container...

Embodiment 2

[0047] Comparing Example 2 with Example 1, the only difference is that when heating the first container, a common electric furnace is used for heating.

Embodiment 3

[0049] Embodiment 3 is compared with embodiment 1, and its difference is only: when the black fungus and solution poured out from the first container and the second container are filtered, adopt common 500 mesh filter screens to filter.

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Abstract

The invention discloses a method for extracting polysaccharides for treating senile hyperlipidemia from black fungus. The method comprises the following steps of A1, crushing the dried black fungus into tiny particles with the particle diameter being 200 to 300 meshes; then, performing soaking for 4 to 5h in warm water at the maintained temperature of 35 to 45 DEG C and the volume being 15 to 20 times; A2, simultaneously putting soaked black fungus and water into a first container for sealing; performing heating treatment for 30 to 40min; enabling the temperature in the first container to reach 50 to 60 DEG C; A3, preparing a second container, wherein the second container is a vacuum container; connecting a pipeline between the first container and the second container; installing a switchvalve on the pipeline; opening the switch valve after the first container and the second container are connected; A4, taking out black fungus and water in the first container and the second container;performing filtering; concentrating the filter liquid; removing protein; performing sedimentation by ethanol; taking precipitates to be dried to obtain agaric polysaccharide. The method has the advantages that the extraction rate of the agaric polysaccharide from the black fungus can be improved; the original activity of the agaric polysaccharide cannot be lowered.

Description

technical field [0001] The invention relates to the technical field of medicine extraction, in particular to a method for extracting and treating senile hyperlipidemia from black fungus. Background technique [0002] Black fungus is one of the important edible fungi in my country. It has multiple health functions such as cooling blood, promoting blood circulation, nourishing qi and strengthening the body. It is an edible and medicinal fungus with high nutritional value. Fungus polysaccharide is one of its main active ingredients. Fungus polysaccharides are composed of monosaccharides such as L-fucose, L-arabinose, D-xylose, D-mannose, D-glucose and glucuronic acid. Salt combination, on the one hand, affects the digestion and absorption of lipids, on the other hand, intervenes in the enterohepatic circulation of bile salts to excrete bile salts from the body, and promotes the continuous conversion of cholesterol in the liver into bile salts, thereby reducing the cholesterol c...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/715A61P3/06
CPCA61K31/715C08B37/0003
Inventor 何菲
Owner AFFILIATED YONGCHUAN HOSPITAL OF CHONGQING MEDICAL UNIV
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