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Pharmaceutical composition for treating diabetic nephropathy

A technology of diabetic nephropathy and composition, applied in the field of medicine for treating diabetic nephropathy

Active Publication Date: 2018-06-01
福建万科进出口贸易有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, the combination of triptolide and psyllium polysaccharides for the prevention and treatment of diabetic nephropathy has not been reported

Method used

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  • Pharmaceutical composition for treating diabetic nephropathy
  • Pharmaceutical composition for treating diabetic nephropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1. Extraction of Plantago Seed Polysaccharide

[0026] Weigh 50g of degreased plantago seeds, add 30 times the amount of 0.5M NaOH, extract for 2h at 80℃, repeat three times, filter, adjust the filtrate to neutral with hydrochloric acid, remove protein by Sevag method, concentrate the crude polysaccharide solution, Add 15% of the volume of hydrogen peroxide, depigment at 60°C, centrifuge, take the supernatant and concentrate, add 4 times the volume of 95% ethanol, settle with alcohol overnight, and centrifuge. The filter residue is washed with ethanol, acetone and ether in turn once, and freeze-dried to obtain.

Embodiment 2

[0029] Take 25g triptolide, 25g plantain seed polysaccharide, 100g microcrystalline cellulose and 220g mannitol and mix them, pass through a 100-mesh sieve, make soft material with ethanol, pass through a 40-mesh sieve for granulation, and then dry at 40°C for 30 Use an 80-mesh sieve to granulate; finally, 20g of povidone is passed through a 100-mesh sieve and mixed with the granules, then 5g of silicon dioxide and 5g of aspartame are added to make 1000 disintegrating tablets, each The tablet weight is 400 mg.

Embodiment 3

[0031] Take 45g triptolide, 5g plantain seed polysaccharide, 120g microcrystalline cellulose and 200g mannitol and mix them, pass through a 100-mesh sieve, make soft material with ethanol, pass through a 40-mesh sieve for granulation, and then dry at 40°C for 30 Use an 80-mesh sieve to sizing; finally, 15g of povidone is passed through a 100-mesh sieve and mixed with the granules, then 8g of silicon dioxide and 7g of aspartame are added to make 1000 disintegrating tablets, each The tablet weight is 400 mg.

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Abstract

The invention relates to pharmaceutical composition for treating diabetic nephropathy. Active ingredients comprise triptolide and semen plantaginis polysaccharides in a weight ratio of (1:20)-(20:1).The two active ingredients in the pharmaceutical composition can produce a synergistic effect, diabetic nephropathy is remarkably treated, toxicity reduction and efficacy enhancement are achieved.

Description

Technical field [0001] The invention relates to the field of pharmacy, in particular to a medicine for treating diabetic nephropathy. Background technique [0002] Diabetic nephropathy (DN) refers to glomerular sclerosis caused by diabetic microangiopathy, also known as diabetic glomerulosclerosis. DN is one of the main chronic complications of diabetes. It is a relatively common disease and the main cause of end-stage renal disease (ESRD). Nearly 1 / 3 of diabetic patients develop diabetic nephropathy. With the increasing number of diabetic patients worldwide, the prevalence of DN has also increased. According to epidemiological statistics, it is estimated that by 2030, the number of diabetic patients worldwide will reach 366 million, and the number of diabetic nephropathy patients will exceed 100 million. [0003] The pathogenesis of DN is complex and has not yet been fully understood. In recent years, clinical and experimental studies have shown that glucose metabolism disorder...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61K31/585A61P3/10A61P13/12
CPCA61K31/585A61K31/715A61K2300/00
Inventor 李一彪潘美玲
Owner 福建万科进出口贸易有限公司