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Angstrom-silver injection liquid capable of inhibiting cancer as well as preparation method and application thereof

A technology for inhibiting cancer and injection, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, powder delivery, etc. It can solve the problems of cancer treatment, which has a long way to go and affects the quality of life of cancer patients.

Inactive Publication Date: 2018-06-01
SHENZHEN AMCAN MEDICAL BIOTECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above treatment methods all have their limitations, especially most of the treatment methods such as chemotherapy and surgery will seriously affect the quality of life of cancer patients, so there is still a long way to go in the treatment of cancer

Method used

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  • Angstrom-silver injection liquid capable of inhibiting cancer as well as preparation method and application thereof
  • Angstrom-silver injection liquid capable of inhibiting cancer as well as preparation method and application thereof
  • Angstrom-silver injection liquid capable of inhibiting cancer as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0042] The preferred preparation process of the injection is as follows:

[0043] (1) the angstrom silver powder that particle diameter is 1-25Ang is added in water, obtains the high-purity angstrom silver solution that concentration is 0.005-0.500g / L;

[0044] (2) Use ultrasonic dispersing equipment to disperse the angstrom silver solution, the ultrasonic power is 3KW, the frequency is 30-40KHZ, and the dispersion time is 30-60s;

[0045] (3) the angstrom silver solution processed through step (2) is 7.5KW with ultrasonic power, and the frequency is 15-20KHZ to carry out atomization, and the atomization equipment works at 2 ± 5 ° C;

[0046] (4) Add fructose to the angstrom silver solution collected by atomization in step (3), control the concentration of fructose to be 0.5-1.0g / L; then carry out ultrasonic dispersion again, the ultrasonic power is 0.5KW, and the frequency is 110- 150KHZ, dispersion time is 10-15s;

[0047] (5) the angstrom silver solution processed through...

Embodiment 1

[0055] Reagents and consumables for detecting the effect of angstrom silver on the proliferation of human non-small cell lung cancer cell A549 and human liver cancer cell HepG2

[0056] 1. HepG2, provided by Huiyuan Biotechnology (Shanghai) Co., Ltd., has passed the mycoplasma test;

[0057] 2. F12K culture medium, Gibco, USA, product number: 21127-022;

[0058] 3. EMEM culture medium, American ATCC, article number: 30-2003;

[0059] 4. Fetal bovine serum, American Hyclone, item number: CH30160.03;

[0060] 5. Penicillin-streptomycin liquid, Invitrogen, USA, product number: 15140-122;

[0061] 6. DG-5 (25Ang) and DG-5 solvent, DG-6 (25Ang) and DG-6 solvent are provided by Emika Pharmaceutical International Group Co., Ltd.;

[0062] 7.STSP, Tocris, UK, Cat#3259;

[0063] 8. DMSO, American Sigma, product number D4540;

[0064] 9. 96-well cell culture plate, Corning, USA, product number: 3610;

[0065] 10. CellTiter-Glo Luminescent Cell Viability Assay, Promega, USA, produc...

Embodiment 2

[0102] Example 2 3D Drug Sensitivity Test Results

[0103]

[0104] For the most effective group, see figure 1 : (White in the pharmacodynamic diagram represents tumor tissue cells) For the group with the worst efficacy, see figure 2

[0105] Among the added drugs, imatinib has a better effect, see image 3 .

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Abstract

The invention relates to angstrom-silver injection liquid capable of inhibiting cancer as well as a preparation method and application thereof. The injection liquid comprises the following componentsaccording to proportion: angstrom-grade elemental silver powder (0.005 to 0.500 g / L), medicinal anhydrous fructose (0.5 to 1.0 g / L) and aseptic distilled water (998.500 to 999.495 g / L). The surface ofa tumor cell membrane takes on high negative charge property, increment of the negative charges on the surface of the membrane is related to the side-chain charges of acidic mucopolysaccharide, DNA and protein on the surface of the membrane, particularly related to increment or revealing of the quantity of sialic acid. The angstrom-silver and silver ions have positive charges, so the angstrom-silver and the silver ions can be bound with protein and nucleic acid molecules, with negative charges, inside and outside cells, synthesis of the protein and replication and transcription of the DNA areinterfered, and the normal vital movement of the cancer cells is damaged.

Description

technical field [0001] The invention relates to an angstrom silver injection for inhibiting cancer, its preparation method and application. Background technique [0002] Cancer has become the second killer of human health worldwide, and cancer treatment has also become an important global issue. In 2015, there were 4.292 million new cancer patients in my country, that is, more than 8 new cancer patients per minute. Among them, liver cancer, lung cancer and pancreatic cancer are the most common cancers, and the number of cancer deaths reached 2.814 million. At present, traditionally, surgery, radiotherapy, chemotherapy and traditional Chinese medicine are still used in my country to fight cancer. With the promotion of modern molecular biology technology and genetic engineering technology, biological therapy has also become the fourth treatment mode. However, the above treatment methods all have their limitations, especially most of the treatment methods such as chemotherapy ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/38A61K9/08A61K47/26A61P35/00
CPCA61K9/0019A61K9/08A61K33/38A61K47/26A61P35/00A61K9/14
Inventor 司徒伟怡谢辉王杨范荣
Owner SHENZHEN AMCAN MEDICAL BIOTECH LTD
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