Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of poly(4-styrenesulfonic acid-co-maleic acid) sodium and medicinal composition thereof

A technology of styrene sulfonic acid and maleic acid, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc., can solve the problems of rare, etc., and achieve abundant sources, low toxicity, and low production costs Effect

Inactive Publication Date: 2011-08-24
南京欧睿医药科技有限公司 +1
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Poly(4-styrenesulfonic acid-co-maleic acid) sodium salt has a wide range of applications in industry and agriculture, and can be used in detergents and dispersants, etc., but there are few reports on its application in the field of medicine and health, especially as an antiviral drug

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of poly(4-styrenesulfonic acid-co-maleic acid) sodium and medicinal composition thereof
  • Application of poly(4-styrenesulfonic acid-co-maleic acid) sodium and medicinal composition thereof
  • Application of poly(4-styrenesulfonic acid-co-maleic acid) sodium and medicinal composition thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] The present invention will be further described below in conjunction with the accompanying drawings showing experimental results.

[0018] Experimental Materials

[0019] 1.1 Poly(4-styrenesulfonic acid-co-maleic acid) sodium salt (PSM);

[0020] Its molecular formula is as follows:

[0021]

[0022] 1.2 Positive control samples: dextran sulfate (Dextran sulfate), zidovudine (AZT), and nevirapine (Nevirapine) were all purchased from SIGMA;

[0023] 1.3 CCK-8, Dojindo Laboratories;

[0024] 1.4 PEI (linear, 25kD), purchased from Polyscience, prepared to 5 mg / ml when used

[0025] The solution;

[0026] 1.5 HIV-1 pseudotype virus system (HIV-1 pseudotype virus)

[0027] 1.6.1 Pseudovirus backbone plasmid: pNL4-3, constructed with a luciferase reporter gene (luciferase reporter gene), cited from the Rockfeller university in the United States;

[0028] 1.6.2 Pseudovirus envelope plasmids derived from the gene sequences of different HIV-1 subtypes, quoted from the A...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an application of poly(4-styrenesulfonic acid-co-maleic acid) sodium and a medicinal composition thereof. The poly(4-styrenesulfonic acid-co-maleic acid) sodium has strong cluster of differentiation4 (CD4) independent human immunodeficiency virus (HIV)-1 infection resistance, and represents good activity on certain clinical isolated strains, including B', B'C and CRF01-AE recombinant subtype. Furthermore, the poly(4-styrenesulfonic acid-co-maleic acid) sodium has good infection resistance on CD4 non-independent HIV-1 infection. In-vitro toxicity experiments on the poly(4-styrenesulfonic acid-co-maleic acid) sodium prove that: the compound has lower toxicity. Finally, cell fusion experiment results prove that the poly(4-styrenesulfonic acid-co-maleic acid) sodium has the effect of inhibiting HIV-1 virus envelop protein gp120 mediated fusing process. The poly(4-styrenesulfonic acid-co-maleic acid) sodium has rich sources and low production cost, and has potentialapplication value serving as a novel HIV-1 resistant medicament and microbicide.

Description

[0001] technical field [0002] The present invention relates to the use of poly(4-styrenesulfonic acid-copolymerization-maleic acid) sodium salt, and also relates to a pharmaceutical composition containing poly(4-styrenesulfonic acid-copolymerization-maleic acid) sodium salt as an active ingredient . Background technique [0003] AIDS is caused by infection with the human immunodeficiency virus (HIV). HIV-1 invasion of target cells is a specific biological process, which requires the binding of the envelope protein gp120 on the surface of the virus to the cell receptor CD4, inducing a change in the conformation of gp120, and then binding to the co-receptor CCR5 or CXCR4 on the cell surface, The fusion protein gp41 that was originally covered by gp120 undergoes a conformational change, exposing its hydrophobic N-terminal fusion peptide sequence and inserting into the host cell membrane, thereby initiating the fusion of the viral venom and the cell membrane, and finally caus...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/795A61P31/18
CPCA61K31/795A61P31/18
Inventor 吴稚伟邱敏孙亦彬蒋海燕
Owner 南京欧睿医药科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com