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Application of poly(4-styrenesulfonic acid-co-maleic acid) sodium and medicinal composition thereof

A technology of styrene sulfonic acid and maleic acid, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc., can solve problems such as rare, and achieve abundant sources, low production costs, and low toxicity Effect

Inactive Publication Date: 2013-04-24
南京欧睿医药科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Poly(4-styrenesulfonic acid-co-maleic acid) sodium salt has a wide range of applications in industry and agriculture, and can be used in detergents and dispersants, etc., but there are few reports on its application in the field of medicine and health, especially as an antiviral drug

Method used

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  • Application of poly(4-styrenesulfonic acid-co-maleic acid) sodium and medicinal composition thereof
  • Application of poly(4-styrenesulfonic acid-co-maleic acid) sodium and medicinal composition thereof
  • Application of poly(4-styrenesulfonic acid-co-maleic acid) sodium and medicinal composition thereof

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Experimental program
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Embodiment Construction

[0017] The present invention will be further described below in conjunction with the accompanying drawings showing experimental results.

[0018] Experimental Materials

[0019] 1.1 Poly(4-styrenesulfonic acid-co-maleic acid) sodium salt (PSM);

[0020] Its molecular formula is as follows:

[0021]

[0022] 1.2 Positive control samples: dextran sulfate (Dextran sulfate), zidovudine (AZT), and nevirapine (Nevirapine) were all purchased from SIGMA;

[0023] 1.3 CCK-8, Dojindo Laboratories;

[0024] 1.4 PEI (linear, 25kD), purchased from Polyscience, prepared to 5 mg / ml when used

[0025] The solution;

[0026] 1.5 HIV-1 pseudotype virus system (HIV-1 pseudotype virus)

[0027] 1.6.1 Pseudovirus backbone plasmid: pNL4-3, constructed with a luciferase reporter gene (luciferase reporter gene), cited from the Rockfeller university in the United States;

[0028] 1.6.2 Pseudovirus envelope plasmids derived from the gene sequences of different HIV-1 subty...

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Abstract

Use of poly(4-styrene sulfonic acid-copoly-maleic acid) sodium salt in the preparation of pharmaceutical inhibiting infection of HIV-1 and pharmaceutical composition thereof. Said pharmaceutical composition comprises poly(4-styrene sulfonic acid-copoly-maleic acid) sodium salt as active ingredient and conventional pharmaceutical carrier.

Description

technical field [0001] The present invention relates to the use of poly(4-styrenesulfonic acid-copolymerization-maleic acid) sodium salt, and also relates to a pharmaceutical composition containing poly(4-styrenesulfonic acid-copolymerization-maleic acid) sodium salt as an active ingredient . Background technique [0002] AIDS is caused by infection with the human immunodeficiency virus (HIV). HIV-1 invasion of target cells is a specific biological process, which requires the binding of the envelope protein gp120 on the surface of the virus to the cell receptor CD4, inducing a change in the conformation of gp120, and then binding to the co-receptor CCR5 or CXCR4 on the cell surface, The fusion protein gp41 that was originally covered by gp120 undergoes a conformational change, exposing its hydrophobic N-terminal fusion peptide sequence and inserting into the host cell membrane, thereby initiating the fusion of the viral venom and the cell membrane, and finally causing the c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/795A61P31/18
CPCA61K31/795A61P31/18
Inventor 吴稚伟邱敏孙亦彬蒋海燕
Owner 南京欧睿医药科技有限公司
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