A kind of synthetic method of anthranilic acid

A technology of anthranilic acid and a synthesis method, which is applied in the field of synthesis of anthranilic acid, can solve the problems of large pollution, low yield, low purity of anthranilic acid, etc., and achieves low environmental pollution, high utilization rate, and waste water volume. less effect

Active Publication Date: 2019-02-19
山东聚强绿洲生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the amidation degradation method of phthalic anhydride is the most widely used, but it will produce a large amount of high-salt and high-concentration organic waste water, causing great pollution
The anthranilic acid produced by the saccharin by-product extraction method has low purity, and is limited by the scale of saccharin production enterprises, the output is very small, and the quality and output cannot meet the market demand

Method used

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  • A kind of synthetic method of anthranilic acid
  • A kind of synthetic method of anthranilic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: the present invention provides a kind of synthetic method of anthranilic acid, specifically comprises the following steps:

[0025] (1) Put 600g of phthalic anhydride and 150g of urea into a three-necked flask, heat up to 140°C and stir for half an hour;

[0026] (2) After the reaction is complete, add 1000g of water for beating, and add 600g of glacial acetic acid;

[0027] (3) Pass in about 400g of chlorine gas under stirring, and absorb the excess chlorine gas with liquid caustic;

[0028] (4) After stirring and reacting at room temperature for three hours, filter to obtain the solid, wash the solid with 100 g of water, and put the mother liquor into the next batch of reaction liquid;

[0029] (5) Put the solid into 1800g of sodium hydroxide solution, the mass percentage concentration is 30%, and stir at room temperature for one hour;

[0030] (6) Add hydrochloric acid to the reaction solution to adjust the pH to 3-4, and a large amount of solids are ...

Embodiment 2

[0033] Embodiment 2: the present invention provides a kind of synthetic method of anthranilic acid, specifically comprises the following steps:

[0034] (1) Put 600g of phthalic anhydride and 150g of urea into a three-necked flask, heat up to 140°C and stir for half an hour;

[0035] (2) After the reaction is completed, add 1500 g of the mother liquor obtained by filtering the previous batch of products to make a slurry (specifically step 4 in Example 1 to obtain the mother liquor);

[0036] (3) Pass in about 400g of chlorine gas under stirring, and absorb the excess chlorine gas with liquid caustic;

[0037] (4) After stirring and reacting at room temperature for three hours, filter to obtain the solid, wash the solid with 100 g of water, and put the mother liquor into the next batch of reaction liquid;

[0038] (5) Put the solid into 1800g liquid caustic soda, stir at room temperature for one hour, and the liquid caustic soda adopts a sodium hydroxide solution with a concen...

Embodiment 3

[0042] Embodiment 3: the present invention provides a kind of synthetic method of anthranilic acid, specifically comprises the following steps:

[0043] (1) Put 600g of phthalic anhydride and 150g of urea into a three-necked flask, heat up to 140°C and stir for half an hour;

[0044] (2) After the reaction is complete, add 1000g of water for beating, and add 600g of glacial acetic acid;

[0045] (3) Add 650g of bromine while stirring, and absorb the excess bromine with liquid caustic soda;

[0046] (4) After stirring and reacting at room temperature for three hours, the solid was obtained by filtration, and the mother liquor was put into the next batch of reaction liquid;

[0047] (5) Put the solid into 1800g liquid caustic soda, stir at room temperature for one hour, and the liquid caustic soda adopts a potassium hydroxide solution with a concentration of 40% by mass;

[0048] (6) Add hydrochloric acid to the reaction solution to adjust the pH to 3-4, and a large amount of ...

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Abstract

The invention relates to a synthesis method of anthranilic acid. The synthesis method comprises the following steps: (1), putting phthalic anhydride and urea into a reaction container, raising the temperature to 140 DEG C, and stirring; (2), after reaction, adding water, and pulping; (3), adding glacial acetic acid and halogen; (4), stirring at room temperature, reacting for three hours, then filtering to obtain a solid, and putting a mother solution into the next batch of a reaction solution; (5), putting the solid into liquid caustic soda, and stirring at room temperature; (6), adding hydrochloric acid into the reaction solution to adjust the pH to 3-4, and separating out a large amount of solid; and (7), filtering and drying to obtain the product anthranilic acid. The synthesis method has the beneficial effects as follows: a halogenating reaction is directly performed on the halogen and phthalamide, and a reaction solvent can be repeatedly used, so that the halogen utilization rateis very high; use of large amounts of acid and alkali is avoided and generation of large amounts of waste salt and waste water is also avoided; and in addition, the waste water has a COD value of 2,000 or below, so that the environmental pollution is very low and the synthesis method is suitable for industrial production.

Description

technical field [0001] The invention relates to a new production method of anthranilic acid, in particular to a synthesis method of anthranilic acid. Background technique [0002] Anthranilic acid, also known as anthranilic acid, is widely used, mainly in dyestuffs, medicine, pesticides, spices and other industries. In terms of fuel, it is mainly used in the manufacture of azo dyes, indigo fuels, acid dyes, oil-soluble pigments and metal complex dyes. In medicine, it is used in the manufacture of antiarrhythmic drugs changroline, vitamin L, non-steroidal anti-inflammatory analgesics mefenamic acid, yantongjing, clohepine, non-barbiturate hypnotic drugs, strong tranquilizers Telden, the antidiabetic drug lasidone, etc. Bactericide and antifungal agent 1,2-benzisothiazolin-3-one, and also used as a complexing reagent for the determination of various heavy metals. [0003] There are three main production routes for the synthesis of anthranilic acid: phthalic anhydride amidat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C227/18C07C229/56C07D209/48
CPCC07C227/18C07D209/48C07C229/56
Inventor 叶华天王涛张朋朋刘琪
Owner 山东聚强绿洲生物科技有限公司
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