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Preparation method of perilla volatile oil beta-cyclodextrin microspheres

A cyclodextrin and volatile oil technology, applied in skin care preparations, medical preparations with inactive ingredients, medical preparations containing active ingredients, etc., can solve problems such as irritation and insoluble perilla volatile oil, etc. The effect of reducing irritation, improving water solubility, and increasing the scope of application

Inactive Publication Date: 2018-06-15
XIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a preparation method of perilla volatile oil β-cyclodextrin microspheres, to solve the problem that perilla volatile oil is insoluble and irritating in hydrophilic solutions

Method used

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  • Preparation method of perilla volatile oil beta-cyclodextrin microspheres

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preparation example Construction

[0034] A preparation method of perilla volatile oil β-cyclodextrin microspheres of the present invention comprises the following steps:

[0035] Step 1, preparation of β-cyclodextrin microspheres

[0036] Step 1.1, add β-cyclodextrin to the aqueous sodium hydroxide solution with a mass concentration of 0.1-1.0g / mL, stir at a constant temperature at 30-40°C until completely dissolved, and the β-cyclodextrin in each ml of aqueous sodium hydroxide solution The quality of essence is 0.2-0.9g;

[0037] Step 1.2, add epichlorohydrin and kerosene in a mass ratio of 3:2-2:1 to the solution in step 1.1 while stirring at a constant temperature, heat up and react, then vacuum filter in turn, use dilute hydrochloric acid, absolute ethanol, Washing with distilled water and acetone, drying and grinding to obtain β-cyclodextrin microspheres;

[0038] Kerosene is the kerosene containing emulsifier Span-80 and Tween-20 with a mass ratio of 3:1;

[0039] Among them, the constant temperature ...

Embodiment 1

[0044] (1) Preparation of β-cyclodextrin microspheres

[0045] Add β-cyclodextrin to 0.1g / mL sodium hydroxide aqueous solution, stir at a constant temperature at 30°C until completely dissolved, and the mass of β-cyclodextrin in each milliliter of sodium hydroxide aqueous solution is 0.2g;

[0046] Add epichlorohydrin and kerosene at a mass ratio of 3:2 to the solution in turn while stirring at a constant temperature, heat up to react, then vacuum filter in turn, use dilute hydrochloric acid, absolute ethanol, distilled water, acetone to wash, dry, and grind in turn, To obtain β-cyclodextrin microspheres, the kerosene is kerosene containing emulsifiers Span-80 and Tween-20 with a mass ratio of 3:1; wherein the constant temperature stirring temperature is 30°C, the stirring time is 3h, and the rotating speed is 1000r / min; The temperature is 60°C, and the reaction time is 6h; the drying temperature is 40°C, and the time is 48h.

[0047] (2) Add β-cyclodextrin microspheres into ...

Embodiment 2

[0050] (1) Preparation of β-cyclodextrin microspheres

[0051] Add β-cyclodextrin to 0.5g / mL sodium hydroxide aqueous solution, stir at a constant temperature at 35°C until completely dissolved, and the mass of β-cyclodextrin in each milliliter of sodium hydroxide aqueous solution is 0.6g;

[0052] Add epichlorohydrin and kerosene at a mass ratio of 2:1 to the solution in turn while stirring at a constant temperature, heat up to react, then vacuum filter in turn, use dilute hydrochloric acid, absolute ethanol, distilled water, acetone to wash, dry, and grind in turn, Obtain β-cyclodextrin microspheres, kerosene is the kerosene containing emulsifier Span-80 and Tween-20 with a mass ratio of 3:1;

[0053] Among them, the constant temperature stirring temperature is 40°C, the stirring time is 2.5h, and the rotation speed is 750r / min; the temperature of the heating reaction is 50°C, and the reaction time is 20h; the drying temperature is 50°C, and the drying time is 36h.

[0054] (...

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Abstract

The invention discloses a preparation method of perilla volatile oil beta-cyclodextrin microspheres. The preparation method comprises the following steps: adding beta-cyclodextrin microspheres into distilled water, and heating till the mixture is dissolved into a saturated solution; cooling and adding perilla volatile oil; sealing and stirring at a constant temperature; cooling and performing suction filtration; washing with petroleum ether and drying to obtain the perilla volatile oil beta-cyclodextrin microspheres. According to the preparation method disclosed by the invention, the perilla volatile oil beta-cyclodextrin microspheres are prepared with a stirring method, so that the water solubility of the perilla volatile oil is enhanced, unfavorable odor is covered, and irritation is relieved; the problems of poor water solubility and high irritation of the perilla volatile oil are solved, the application range of the perilla volatile oil is expanded greatly, and the application thought of the perilla volatile oil in the fields of foods, medicines and cosmetics is expanded; the preparation method has important practical significance.

Description

technical field [0001] The invention belongs to the technical field of microsphere preparation methods, and in particular relates to a preparation method of perilla volatile oil β-cyclodextrin microspheres. Background technique [0002] The traditional Chinese medicine perilla is the leafy twig of Perilla frutescens (L.) Brltt, a plant of the genus Perilla in the Labiatae family. It is used as medicine with stems, leaves and seeds. Perilla is a commonly used medicine in clinical practice. It has the functions of dispelling cold, relieving the exterior, regulating qi and widening the middle. It is mainly used to treat colds and fever, fear of cold, no sweat, chest tightness, cough, and detoxification of fish and crabs. It can also be eaten daily. The main components of perilla oil are D-limonene, perillene, perillone, β-caryophyllene, and β-bisabolene. Because perilla volatile oil is insoluble in water and is irritating to skin and mucous membranes, it is difficult to apply ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/535A61K47/69A61K8/92A61K8/73A61K8/11A61Q19/00
CPCA61K8/11A61K8/738A61K8/922A61K36/535A61K2800/10A61K2800/56A61Q19/00
Inventor 闫平张彦张寒宋静郑梦迪
Owner XIAN MEDICAL UNIV
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