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Preparation method and application of injectable polysaccharide and clay composite gel

A composite gel and clay technology, which is applied in applications, pharmaceutical formulations, surgical adhesives, etc.

Active Publication Date: 2018-06-15
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, free clay can cause thrombosis

Method used

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  • Preparation method and application of injectable polysaccharide and clay composite gel
  • Preparation method and application of injectable polysaccharide and clay composite gel
  • Preparation method and application of injectable polysaccharide and clay composite gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Carboxymethyl chitosan / montmorillonite nanocomposite prepared by microwave intercalation reaction (in the composite, the total weight percentage of each component is respectively carboxymethyl chitosan 99%, montmorillonite 1%) Add deionized water, stir at 25°C for 0.5 hours to obtain a solution with a concentration of 0.5 mg / mL, and then concentrate by rotary evaporation at 80°C for 4 hours to obtain a composite gel with a mass concentration of 80%.

Embodiment 2

[0038] The chitosan quaternary ammonium salt / organic montmorillonite nanocomposite prepared by microwave intercalation reaction (in the composite, the total weight percentage of each component is respectively chitosan quaternary ammonium salt 80%, organic montmorillonite 20% %) was added to deionized water, stirred at 45°C for 2 hours to obtain a solution with a concentration of 1 mg / mL, and then concentrated by rotary evaporation at 60°C for 2 hours to obtain a composite gel with a mass concentration of 60%.

Embodiment 3

[0040] Carboxymethyl chitosan / rectorite nanocomposite prepared by microwave intercalation reaction (in the composite, the total weight percentage of each component is respectively carboxymethyl chitosan 90%, rectorite 10%) Add deionized water, stir at 50°C for 8 hours to obtain a solution with a concentration of 2 mg / mL, and then concentrate by rotary evaporation at 50°C for 1 hour to obtain a composite gel with a mass concentration of 50%.

[0041] figure 1 For the scanning electron micrograph of the carboxymethyl chitosan quaternary ammonium salt / organic rectorite composite gel prepared in embodiment 3, from figure 1 It can be seen that the clay particles are uniformly dispersed in the polysaccharide matrix, and the encapsulation of polysaccharides restricts the release of clay particles.

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Abstract

The invention discloses a preparation method and an application of injectable polysaccharide and clay composite gel. The preparation method comprises the following steps: adding an exfoliated polysaccharide and clay compound into deionized water, performing full and uniform stirring to obtain an exfoliated polysaccharide and clay compound solution, and performing rotary evaporation concentration to obtain the injectable polysaccharide and clay composite gel. The interaction between polysaccharides and clay restricts the diffusion of the clay, so the composite gel solves the problem of thrombuseasily caused by a simple clay haemostasis material, is injectable, and also can be directly applied to wounds as a haemostasis material in order to achieve rapid hemostasis and bacteriostasis effects.

Description

technical field [0001] The invention relates to the technical field of biological hemostatic materials and gel preparation, in particular to a preparation method and application of an injectable polysaccharide clay composite gel. Background technique [0002] Surgical and traumatic operations are often accompanied by massive bleeding from the wound, which poses great danger to the lives of patients. Therefore, rapid and effective hemostatic materials have always been a research hotspot in the field of biomaterials. Clinically, the shape of traumatic wounds is changeable and complex, and traditional hemostatic materials cannot meet the requirements of patients with different wound sites, sizes, and exudate volumes. In recent years, injectable gel materials have attracted extensive attention from researchers because of their convenient operation, strong plasticity, and ability to maintain a moist external environment for wounds. [0003] Chitosan has functions such as antibac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00
CPCA61L24/0015A61L24/0031A61L24/0068A61L24/0089A61L2300/102A61L2300/236A61L2300/404A61L2300/418A61L2400/04A61L2400/06
Inventor 王小英李晓云孙润仓
Owner SOUTH CHINA UNIV OF TECH
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