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Silver nanoparticle composite hydrogel as well as preparation method and application thereof

A composite hydrogel and silver nanoparticle technology, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problem of high cytotoxicity, poor biocompatibility, and increased water coagulation. The difficulty of glue and other problems, to achieve the effect of simple preparation method, low cost, good biocompatibility and antibacterial performance

Active Publication Date: 2020-07-14
NANHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, many documents and patents have reported the use of silver nanoparticle gel as an antibacterial agent. When preparing silver nanoparticles, chemical reagents with high toxicity have been used, which have high cytotoxicity and relatively poor biocompatibility (publication number It is the Chinese patent of CN101664563A); Silver nanoparticles are prone to agglomeration and serious phenomenon, and the uneven dispersion causes its antibacterial performance to be affected (publication number is the Chinese patent of CN102218155A); In addition, polymer environment is needed when preparing silver nanoparticles (disclosed Chinese Patent No. CN106146862A)
[0006] Most of the hydrogels containing silver nanoparticles reported in the above literature require a polymer environment, or need to add a reducing agent or a stabilizer, and some require ultrasonic or ultraviolet light to form, which increases the water content of silver nanoparticles. The difficulty of gel preparation

Method used

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  • Silver nanoparticle composite hydrogel as well as preparation method and application thereof
  • Silver nanoparticle composite hydrogel as well as preparation method and application thereof
  • Silver nanoparticle composite hydrogel as well as preparation method and application thereof

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preparation example Construction

[0032] Based on the performance and application requirements of the hydrogel containing silver nanoparticles, the application provides a method for preparing a silver nanoparticle composite hydrogel, the formation of the silver nanoparticle composite hydrogel is related to the gel factor Optical activity is related, homochiral ligands (L-HAIP or D-HAIP) and silver salts can form hydrogels, while racemates ((L+D)-HAIP) and silver salts can form hydrogels under the same conditions The gel cannot be formed; the preparation method of the composite hydrogel is simple and the preparation cost is low. The composite hydrogel has injectability, good biocompatibility and excellent antibacterial properties. Specifically, the application provides a method for preparing a silver nanoparticle composite hydrogel, comprising the following steps:

[0033] Adjust the pH of the aqueous solution of the chiral tryptophan derivative shown in the formula (I) or shown in the formula (II) to alkaline...

Embodiment 1

[0046] Weigh 10mg of L-HAIP (or D-HAIP) sample respectively, and prepare 1mL of L-HAIP (or D-HAIP) aqueous solution, the solution is colorless and transparent; prepare 0.2M AgNO 3 aqueous solution;

[0047] Pipette 195 μL of the above-mentioned L-HAIP (or D-HAIP) aqueous solution, adjust the pH of the solution to 8-9, and add 5 μL of AgNO 3 The aqueous solution was mixed in a glass bottle and placed in the dark; it was found that the above mixture formed a yellow AgNPs-HAIP composite hydrogel after about 10 hours.

Embodiment 2

[0049] Weigh 10mg of L-HAIP (or D-HAIP) sample respectively, and prepare 1mL of L-HAIP (or D-HAIP) aqueous solution, the solution is colorless and transparent; prepare 0.2M AgNO 3 aqueous solution;

[0050] Pipette 195 μL of the above L-HAIP (or D-HAIP) aqueous solution, adjust the pH of the solution to 8-9, and add 5 μL of AgNO 3 aqueous solution, mixed in a glass bottle, and exposed to natural light; it was found that the above mixture formed a yellow Ag NPs-HAIP composite hydrogel after about 5 minutes, as figure 1 .

[0051] Through the comparison of Examples 1 and 2, it is found that light can accelerate the formation of silver nanoparticles.

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Abstract

The invention provides silver nanoparticle composite hydrogel as well as a preparation method thereof. The pH of an aqueous solution of a chiral tryptophan derivative is adjusted to be alkaline, then,the aqueous solution is mixed with an aqueous solution of a silver salt, and the silver nanoparticle composite hydrogel is obtained after standing. The invention further provides application of the silver nanoparticle composite hydrogel. Ultrasonic treatment or additional reducing agents and stabilizing agents are not required during formation of the silver nanoparticle composite hydrogel. The preparation method of the composite hydrogel is simple and low in preparation cost. The composite hydrogel has injectability, good biocompatibility and excellent antibacterial properties.

Description

technical field [0001] The invention relates to the field of hydrogel technology, in particular to a preparation method and application of a silver nanoparticle composite hydrogel. Background technique [0002] Supramolecular gels are small molecule gels, which are fibers assembled by non-covalent bonds such as hydrogen bonds, π-π stacking, hydrophobic-hydrophobic interactions, and electrostatic interactions between small molecules (gelling factors). Three-dimensional network structure, which binds the jelly-like substance formed by the solvent. We call the small molecule gels that bind water molecules in the network structure as supramolecular hydrogels. Due to the weak non-covalent bond force in the supramolecular gel system, when the external conditions change (such as machinery, etc.), the gel will collapse, and when the conditions are restored, the gel will also recover. Molecular hydrogels are responsive to multiple stimuli. Due to their good biocompatibility and bi...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K33/38A61K47/22A61P31/04
CPCA61K33/38A61K9/06A61K9/0024A61K47/22A61P31/04Y02A50/30
Inventor 王晓娟魏传晚龚小晴
Owner NANHUA UNIV
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