Method for removing human gene sequence in macro genome sequencing data
A technology of sequencing data and metagenomics, which is applied in the field of genetic engineering, can solve the problems of insufficient removal of human genome sequences and high false positives in microbial analysis, and achieve the effect of increasing speed and saving computing resources
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[0062] In order to express the present invention more clearly, the present invention will be further described below with reference to the accompanying drawings.
[0063] See figure 1 , The method for removing human gene sequences from metagenomic sequencing data of the present invention includes the following steps:
[0064] Step S1: Construct a reference gene set from the original sequencing data of the Thousand Genome Project samples, and after downloading it, first perform quality control on the data and filter the low-quality data to obtain high-quality data, which is used for sequencing read comparison , So as to better remove human read;
[0065] Step S2: After obtaining the high-quality sequencing reads of thousands of genome data, use genome assembly software to assemble them into longer gene fragments, and then compare them with the sequencing reads as a reference sequence. After the assembly is completed, select the length greater than The 150bp gene fragment is used as t...
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