Application of coronary heart disease vaccine based on (M)T-DC (Target-dendritic cell) technology

Abstract

The invention relates to application of coronary heart disease vaccine based on a (M)T-DC (Target-dendritic cell) technology. An autologous dendritic cell preparation is obtained by using specific single-epitope multiple antigen peptides for in-vitro sensitization of dendritic cell, is jointly used with mesenchymal stem cells to repair vascular endothelium damaged cells and serves as venous re-transfusion type coronary heart disease vaccine. Removal of a vascular endothelial infection factor is interfered by the (M)T-DC technology, the vaccine can penetrate into the local lesion in a targetedway, corresponding treatment courses of mesenchymal stem cell treatment with multidirectional differentiation potential is also adopted, so as to repair blood vessel endothelium, and cicatrix is dissolved, so that the treatment aim is fulfilled.

Description

technical field [0001] The invention relates to a vaccine, in particular to the application of a coronary heart disease vaccine based on (M)T-DC technology. Background technique [0002] Coronary heart disease, full name coronary atherosclerotic heart disease, is also known as the first killer of human beings. According to the statistics of the World Health Organization, about 17 million people die from coronary heart disease every year in the world, accounting for more than 50% of the death toll from the disease. There are as many as 60 million patients with coronary heart disease in my country, and now it has become a fatal disease for middle-aged and even young people in the world. It is caused by coronary atherosclerosis that causes stenosis or occlusion of the vascular lumen, causing myocardial ischemia, hypoxia, and even partial myocardial necrosis. disease. It mostly occurs after the age of 40, more men than women, and more mental workers. Divided into five types: a...

AI Technical Summary

Problems solved by technology

Long-term low-virulence infection will cause the immune system to gradually adapt to this infection. In the case of low immunity, the corresponding immune response cannot be caused against it, resulting in immune tolerance. The body cannot recognize the relevant pathogenic microorganisms, which will lead to pathogenic microorganisms. Long-term persistent infection, causing long-term damage to the body

[0004] This type of infection will cause serious pathological damage to the cardiovascular and cerebrovascular, and the continuous damage of vascular endothelial cells will cause diseases of the vascular system; the destruction of the vascular endothelium will form microthrombi, and the formation of microthrombi will block capillaries, resulting in the slow function of vascular cells. Regression, the progressive damage of blood vessels slowly accumulates, changing from quantitative deformation to qualitative change. Once a breakthrough occurs, the damage to organ function is irreversible; it will lead to a decline in the function of the blood supply system, and damage to blood vessel function will lead to diseases such as coronary heart disease.

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