Screening method for precise therapeutics of liver-metastasis triple-negative breast cancer

Abstract

The invention provides a screening method for precise therapeutics of the liver-metastasis triple-negative breast cancer. The method comprises the following steps: acquiring RNAs from the liver-metastasis tissue of patients with the liver-metastasis triple-negative breast cancer and further acquiring the gene information of the RNAs; finding out genes with high expression exceeding normal liver gene expression from the gene information; carrying out data mining on the high-expression genes so as to obtain the gene expression profile of breast cancer liver-metastasis tissue of the patients andthe gene expression profile of primary ductal breast cancer; subjecting the gene expression profiles to topology analysis so as to obtain corresponding genomic imprinting expression; and finding out drugs targeting to the genomic imprinting expression from a drug database and screening out precise therapeutics for the liver-metastasis triple-negative breast cancer of the patients according to thelaws of Chinese government. The screening method provided by the invention is clear and simple and is easy to operate; and the screened therapeutics are high in precision, good in prognosis effect andlow in side-effect and bring good news to patients with the liver-metastasis triple-negative breast cancer.

Description

technical field [0001] The invention relates to a method for screening precision medicines for triple-negative breast cancer, especially triple-negative breast cancer with liver metastases, and belongs to the technical field of precision medicine screening for metastatic breast cancer. Background technique [0002] Female mammary glands are composed of skin, fibrous tissue, mammary glands and fat. Breast cancer is a malignant tumor that occurs in the glandular epithelial tissue of the breast. At present, breast cancer has become a common tumor that threatens women's physical and mental health, and is a major public health problem in the current society. [0003] Breast cancer is not an important organ to maintain human life activities. In situ breast cancer is not fatal, but because breast cancer cells lose the characteristics of normal cells, the connections between cells are loose and easy to fall off. Once cancer cells fall off, free cancer cells It can spread throughou...

AI Technical Summary

Problems solved by technology

[0011] Although, with the deepening of genomics research and the emergence of high-throughput and ultra-high-throughput technologies such as proteomics and transcriptomics developed on this basis, it is relatively easy for clinicians and molecular biologists to learn from individual The disease-related individual differences between patients are analyzed and identified in the genome, and these differences are used to rationally guide clinical treatment and clinical medication. screening method

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