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Preparation method of nano-magnetic beads modified by gold nanoparticles

A gold nanoparticle and nanomagnetic bead technology, which is applied in the direction of nanotechnology, nanotechnology, nanotechnology, etc. for materials and surface science, can solve the problem of uneven coating on the surface of magnetic microspheres, poor stability of composites, and problems in the synthesis process. Harsh and other problems, to achieve the effect of improving stability, uniform modification, and simple process

Active Publication Date: 2018-07-10
ZHEJIANG FORESTRY UNIVERSITY +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the main methods for preparing MB@Au include self-assembly method, magnetron sputtering method, microemulsion method, wet chemical method, laser radiation method, seed growth method, sonochemical method, chemical reduction method, Frens method, etc. The method has the following disadvantages: the synthesis process is too harsh, the surface of the magnetic microspheres is unevenly coated, and the stability of the complex is poor

Method used

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  • Preparation method of nano-magnetic beads modified by gold nanoparticles
  • Preparation method of nano-magnetic beads modified by gold nanoparticles
  • Preparation method of nano-magnetic beads modified by gold nanoparticles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: Preparation of ferric oxide nano-magnetic beads

[0038] The preparation process of ferroferric oxide nano-magnetic beads is referred to (Liu Chuanyong. The solvothermal preparation of magnetic ferroferric oxide microspheres and its silica coating research [D]. Qingdao University, 2014.), for the obtained four Fe3O3 nanoparticles were characterized by SEM, such as figure 1 As shown, the diameter is in the range of 100-500nm, which shows that the surface is round and smooth.

Embodiment 2

[0039] Embodiment 2: Preparation of nano magnetic beads modified by gold nanoparticles

[0040] (1) Weigh 20mg of Fe3O4 nano-magnetic beads cleaned by 0.1M nitric acid ultrasonic rinse, add 10ml of glucose solution (0.5M), ultrasonically disperse and move into a hydrothermal kettle, tighten the tank, and move into an oven , heated to 160 degrees, reacted for 4 hours, took out and cooled to room temperature. After the supernatant was discarded, the bottom material was magnetically separated and washed with deionized water several times to remove impurities and obtain glycosylated nano-magnetic beads.

[0041] SEM characterization of glycosylation-modified nano-magnetic beads, such as figure 2 As shown, the diameter is 250nm ~ 400nm, and figure 1 Comparing the morphology of the Fe3O4 nano-magnetic beads in , it can be seen that there is obviously a layer of inclusions on the surface of the glycosylated magnetic beads.

[0042] (2) Disperse 20 mg of the above-mentioned glycos...

Embodiment 3

[0048] Embodiment 3: Preparation of nano magnetic beads modified by gold nanoparticles

[0049] Test with reference to Example 2, the difference is that step (1) is repeated twice, and the glycosylation modification is carried out twice, and the SEM of the nano magnetic beads modified by the gold nanoparticles of the gained is as follows: Figure 5 shown, with image 3 In comparison, the thickness of the glycosylation coating was significantly increased.

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Abstract

The invention relates to a preparation method of nano-magnetic beads modified by gold nanoparticles. The preparation method comprises the following steps: (1) dispersing ferroferric oxide nano-magnetic beads in a sugar solution, and carrying out a hydrothermal reaction at 160-220 DEG C so as to obtain nano-magnetic beads modified through glycosylation, wherein a monosaccharide solution or an oligosaccharide solution serves as the sugar solution; and (2) dispersing the nano-magnetic beads modified through glycosylation in a trisodium citrate solution, and then adding a chloroauric acid solutionfor a reduction reaction, so as to obtain the nano-magnetic beads modified by the gold nanoparticles. The preparation process is simple; the surfaces of the obtained nano-magnetic beads are uniformlymodified; and meanwhile, the stability and the application performance of such composite magnetic beads are improved.

Description

technical field [0001] The invention relates to the field of preparation of magnetic nanometer materials, in particular to a method for preparing nanometer magnetic beads modified by gold nanoparticles. Background technique [0002] Magnetic nanomaterials have made great progress in the fields of medical testing, gene diagnosis, environmental pollutant analysis, food safety analysis and other fields. At present, the research focus is on the preparation of new magnetic nanomaterials. Compared with other nanomaterials, magnetic nanomaterials have the characteristics of fast magnetic separation, which greatly reduces the sample pretreatment steps. [0003] Introducing specific metal nanomaterials to the surface of magnetic materials can effectively improve the assembly and adsorption capabilities of magnetic nanomaterial biomolecules, improve the sensitivity of magnetic nanomaterials for analytical testing and expand the use of magnetic nanomaterials in medical diagnosis and ot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F9/24B22F1/02B82Y40/00B82Y30/00
CPCB82Y30/00B82Y40/00B22F9/24B22F1/054B22F1/17
Inventor 庞林江权浩然张宜明孙瑛王萍亚路兴花成纪予
Owner ZHEJIANG FORESTRY UNIVERSITY
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