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Applications of total cyclopentene iridoid glycoside of Hedyotis diffusa Willd in preparation of acute kidney injury prevention and treatment drugs

A technology of total cyclopentene iridoid glycosides and Hedyotis diffusa can be applied in the field of pharmaceutical preparations, and can solve the problems of complex chemical composition, not preventing acute kidney injury, etc., and achieve the effect of reducing inflammatory infiltration and achieving remarkable effect.

Active Publication Date: 2018-07-13
广州南方医大科技园有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the water extract of Hedyotis diffusa is a mixture with complex chemical components, mainly including terpenoids, flavonoids, anthraquinones, phenylpropanoids, coumarins, volatile oils, acid-containing compounds, and polysaccharides and other classes, most of the compounds are not active ingredients against acute kidney injury

Method used

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  • Applications of total cyclopentene iridoid glycoside of Hedyotis diffusa Willd in preparation of acute kidney injury prevention and treatment drugs
  • Applications of total cyclopentene iridoid glycoside of Hedyotis diffusa Willd in preparation of acute kidney injury prevention and treatment drugs
  • Applications of total cyclopentene iridoid glycoside of Hedyotis diffusa Willd in preparation of acute kidney injury prevention and treatment drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1 (preparation of total cyclopentene iridoid glycosides of Hedyotis diffusa)

[0017] Take the raw material of Hedyotis diffusa and grind it, pass through a No. 2 sieve to get the coarse powder, take 500 g of the coarse powder, add 5 liters of ethanol with a volume concentration of 75% to reflux and extract twice, each time for 1 hour, concentrate under reduced pressure at 60°C until the relative density is 1.10- 1.20; add 0.5% by weight of activated carbon to the concentrated solution for decolorization, centrifuge at high speed, take the supernatant, and dry it in vacuum at 60°C to obtain the crude extract of total cyclopentene iridoid glycosides of Hedyotis diffusa; the crude extract Dissolve in 30% methanol, use ODS open column as stationary phase, elute with 30% methanol aqueous solution, recover methanol at 60°C, and vacuum dry at 60°C to obtain the total cyclopentene iridoid glycosides of Hedyotis diffusa.

[0018] Get above-mentioned total cyclopenten...

Embodiment 2

[0021] Embodiment 2 (effect experiment)

[0022] 1. Effect of total cyclopentene iridoid glycosides of Hedyotis diffusa on kidney index in mice with LPS-induced kidney injury

[0023] 48 Kunming mice, 18-20g, were randomly divided into blank group, model group, low-dose group, middle-dose group, high-dose group and water extract group, 8 in each group, half male and half male. During the experiment, the mice had free access to food and drink. Blank group: intraperitoneal injection of normal saline at a dose of 0.2ml / 20g for 7 consecutive days (except twice a day on the fifth day, and other injections once a day); model group: intraperitoneal injection of normal saline at a dose of 0.2ml / 20g / day, For 7 consecutive days, once a day, and intraperitoneally inject 6 mg / kg LPS on the 5th day; low dose group: intraperitoneally inject the total cyclopentene iridoids of Hedyotis diffusa prepared in Example 1 at a dose of 80 mg / kg / day Glycosides, 1 time a day for 7 consecutive days, a...

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Abstract

The invention relates to applications of the total cyclopentene iridoid glycoside of Hedyotis diffusa Willd in preparation of acute kidney injury prevention and treatment drugs. According to the present invention, in the applications, with the drugs, the inflammatory infiltration of renal tissue can be significantly reduced, the amount of TNF-alpha, IL-1beta, IL-6 and MCP-1 can be effectively inhibited, and the kidney injury prevention and treatment effects are remarkable.

Description

technical field [0001] The invention relates to a pharmaceutical preparation containing organic active ingredients, in particular to a drug containing cyclopentene iridoid glycosides, which can prevent acute kidney injury. Background technique [0002] Acute kidney injury (acute kidney injury, AKI) is a multidisciplinary clinical common and frequently-occurring disease, mainly manifested in the rapid decline of renal function and the accumulation of metabolic waste, eventually leading to acute renal failure. In recent years, with the increase in the types of drugs, the intervention of chemotherapy, radiotherapy, contrast examination and other treatment methods has greatly increased the burden on the kidneys and the probability of damage, leading to an increasing incidence of acute kidney injury. Once acute kidney injury occurs, the mortality rate of patients increases significantly, and the fatality rate of severe cases is as high as more than 50% (Yin Lianhong, Qi Meng, Pen...

Claims

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Application Information

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IPC IPC(8): A61K36/748A61P13/12
CPCA61K36/748A61K2236/333A61K2236/39A61K2236/55
Inventor 刘孟华唐斓刘叔文何敬愉
Owner 广州南方医大科技园有限公司
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