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Multifunctional composite hydrogel for injection and preparation method thereof

A composite gel and composite technology, applied in the field of biomedicine, can solve the problems of poor mechanical properties, poor permeability, insufficient bionic system construction, etc., achieve good stability, promote regeneration and repair effects

Active Publication Date: 2018-07-20
无锡凯尔富医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the existing traditional drugs for the treatment of osteoarthritis and the latest injectable medical hydrogel drugs have insufficient biomimetic system construction, poor permeability in the cartilage matrix, long-lasting anti-inflammatory effects, lack of tissue repair effects and Uncontrollable degradation rate of natural polymers, poor mechanical properties, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Specific steps are as follows:

[0054] (1) Preparation of Col-HA-PVP composite gel

[0055] First, add 600 mg HA and 60 mg sodium hydroxide to 10 mL of deionized water, and stir to dissolve. Then, an appropriate amount of STMP aqueous solution with a concentration of 0.25 g / mL was added to the HA aqueous solution, and at the same time, 5% by HA mass of Col was added, and cross-linked overnight at room temperature. After the cross-linked product is naturally dried, rinse it with deionized water several times, and then soak in deionized water for more than 2 hours to remove the excess cross-linking agent completely, and prepare a 1% mass fraction of Col-HA aqueous solution (A) . Then, 2.5 g of PVP was added to 10 mL of deionized water, and the mixture was stirred and dissolved completely at 80° C. to prepare an aqueous solution (B) with a mass fraction of 25%. Finally, the A and B solutions were mixed in a volume ratio of 1:1, the bubbles were removed at rest, and 20 mL of...

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PUM

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Abstract

The invention relates to multifunctional composite hydrogel for an injection and a preparation method thereof, and belongs to the field of biological medicines. Such multifunctional composite hydrogelfor the injection, which is provided by the invention, is Col-HA-PVP (Collagen-Hyaluronic Acid-Polyvinyl Pyrrolidone)-Nanoparticles quaternary composite hydrogel which is formed by compositing collagen (Col), hyaluronic acid (HA), polyvinyl pyrrolidone (PVP) and poly(lactic-co-glycotic acid) (PLGA) clad heparan sulfate (HS) and transforming growth factor-beta (TGF-beta), and the multifunctional composite hydrogel is used for highly simulating the composition and structure of an extracellular matrix (ECM), has better stability, water retention rate and mechanical performance, and meanwhile, can be used for promoting the regeneration and restoration of bone tissue.

Description

Technical field [0001] The invention relates to a multifunctional composite hydrogel for injection and a preparation method thereof, and belongs to the field of biomedicine. Background technique [0002] Osteoarthritis, also known as degenerative joint disease and osteoarthrosis, is closely related to bone hyperplasia. Bone hyperplasia is closely related to human aging. Most elderly people may be accompanied by bone hyperplasia and are naturally prone to osteoarthritis. Clinical data shows that the prevalence rate of osteoarthritis in people under 45 years old is only 2%, while the prevalence rate in people over 65 years old is as high as 68%. According to doctors, people from all ages suffer from osteoarthritis in varying degrees. The life expectancy of severe inflammation shortens by 10 to 15 years. [0003] The currently commonly used drugs for the treatment of osteoarthritis mainly include non-steroidal anti-inflammatory drugs, glucocorticoids, viscoelastic supplement therapy ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K9/16A61K38/18A61K31/727A61K47/42A61K47/36A61K47/34A61K47/32A61P19/02A61P29/00
CPCA61K9/0024A61K9/06A61K9/1676A61K31/727A61K38/1841A61K47/32A61K47/34A61K47/36A61K47/42A61K2300/00
Inventor 邓超陈敬华邱立朋闫昳姝
Owner 无锡凯尔富医药科技有限公司
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