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Intelligent graphene nano-material with high chiral selectivity as well as preparation and application thereof

A technology of nanomaterials and graphene, which is applied in the field of intelligent graphene nanomaterials and its preparation and application, and can solve problems such as difficult analysis and regeneration of chiral selective agents, application limitations of large-scale or industrialization, and small processing capacity.

Active Publication Date: 2018-07-20
SOUTHWEST UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Existing amino acid enantiomeric resolution methods include direct resolution and indirect resolution. Indirect resolution methods such as chromatography and electrophoresis, although they have high chiral selectivity, are often costly and difficult to operate. Complicated; direct resolution methods such as membrane separation method, crystallization method, etc., and the processing capacity is very limited
[0004] Part of the prior art has further studied the possibility of using certain magnetic nanomaterials as amino acid enantiomers for direct resolution, such as the use of macrocyclic antibiotics such as coplanin, bovine serum albumin or human serum albumin on silica Coated Fe 3 o 4 Magnetic nanoparticles are functionally modified to prepare a series of chiral magnetic nano-selectors. However, when using these chiral selectors to split amino acid enantiomers, the operation is usually complicated and the environmental friendliness is poor. After the separation of amino acid enantiomers, it is difficult to quickly and easily realize the analysis of enantiomer molecules and the regeneration of chiral selectors
[0005] In order to solve the above-mentioned technical problems, the inventors have developed a chiral magnetic Fe with temperature sensitivity in their research. 3 o 4 Nanocomposite particles realize simple operation and environmental friendliness in the separation of amino acid enantiomers, and can quickly and easily realize the resolution of enantiomer molecules and the effective regeneration of chiral selectors after separation, but in further It is found in the application that the processing volume of these new materials is small, which has certain limitations for large-scale or industrial applications

Method used

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  • Intelligent graphene nano-material with high chiral selectivity as well as preparation and application thereof
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  • Intelligent graphene nano-material with high chiral selectivity as well as preparation and application thereof

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Embodiment 1

[0067] 1. Prepare smart graphene nanomaterials with high chiral selectivity through the following process:

[0068] (1) Preparation of graphene oxide (GO): Add 1g of graphite powder and 1g of NaNO to a 500mL beaker in sequence 3 and 50 mL concentrated H 2 SO 4 , Stir well under the condition of ice-water bath, slowly add 6gKMnO 4 (complete addition within 30min), continue to stir in the ice-water bath for 0.5h, then remove the ice-water bath, put the mixed solution in a 40°C oil bath and continue to react for 1.5h, then slowly add 100mL of deionized water, and heat up to 90°C Continue to react for 0.5h. After the reaction is over, add 100mL of deionized water to the mixture again, and add H 2 o 2 Until no bubbles are generated, the solution turns from brown to golden yellow at this time, the reaction solution is suction filtered while it is hot, the filter cake is washed with dilute HCl and deionized water by centrifugation until the supernatant is neutral, and the product...

Embodiment 2

[0105] Smart graphene nanomaterials with high chiral selectivity were prepared by the following process:

[0106] (1) Preparation of graphene oxide (GO): Add 1g of graphite powder and 1g of NaNO to a 500mL beaker in sequence 3 and 50 mL concentrated H 2 SO 4 , Stir well under the condition of ice-water bath, slowly add 6gKMnO 4 (complete addition within 30min), continue to stir in the ice-water bath for 0.5h, then remove the ice-water bath, put the mixed solution in a 40°C oil bath and continue to react for 1.5h, then slowly add 100mL of deionized water, and heat up to 90°C Continue to react for 0.5h. After the reaction is over, add 100mL of deionized water to the mixture again, and add H 2 o 2 Until no bubbles are generated, the solution turns from brown to golden yellow at this time, the reaction solution is suction filtered while it is hot, the filter cake is washed with dilute HCl and deionized water by centrifugation until the supernatant is neutral, and the product i...

Embodiment 3

[0112] Smart graphene nanomaterials with high chiral selectivity were prepared by the following process:

[0113] (1) Preparation of graphene oxide (GO): Add 1g of graphite powder and 1g of NaNO to a 500mL beaker in sequence 3 and 50 mL concentrated H 2 SO 4 , Stir well under the condition of ice-water bath, slowly add 6gKMnO 4 (complete addition within 30min), continue to stir in the ice-water bath for 0.5h, then remove the ice-water bath, put the mixed solution in a 40°C oil bath and continue to react for 1.5h, then slowly add 100mL of deionized water, and heat up to 90°C Continue to react for 0.5h. After the reaction is over, add 100mL of deionized water to the mixture again, and add H 2 o 2 Until no bubbles are generated, the solution turns from brown to golden yellow at this time, the reaction solution is suction filtered while it is hot, the filter cake is washed with dilute HCl and deionized water by centrifugation until the supernatant is neutral, and the product i...

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Abstract

The invention discloses an intelligent graphene nano-material with high chiral selectivity as well as preparation and application thereof. The material is prepared from graphene, a temperature-sensitive component, a magnetic component and the like. The material disclosed by the invention has high chiral selectivity, temperature-sensitive performance and magnetic responsiveness; the material has the advantages of simplicity in operation, high resolution efficiency, convenience for recycling materials, and environment-friendly operation process in chiral resolution of an amino acid enantiomer, and has a good industrial application prospect.

Description

technical field [0001] The invention belongs to the technical field of graphene nanomaterials, and relates to an intelligent graphene nanomaterial, in particular to an intelligent graphene nanomaterial with high chirality selectivity and its preparation and application. Background technique [0002] When more active ingredients or living substances are actually used, only a part with a specific chiral structure can be directly utilized by the human body. For example, amino acids, which are an important part of living organisms, actually have two different configurations, D-type and L-type, and the amino acid counterparts of these two different configurations often have significantly different effects. L-type amino acids are active or beneficial to the human body, while D-type amino acids are not active or even have serious negative effects on the human body; on the other hand, D-type amino acids also have some important functions, such as participating in the regulation of h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/02C08F292/00C08F220/54C08F220/32
CPCC08F292/00C08G81/021C08F220/54
Inventor 程昌敬杨小荣宋晓东余海溶
Owner SOUTHWEST UNIVERSITY FOR NATIONALITIES
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